Name: Afatinib Malate Tablets 30?mg Jiyue - Arizona-mall
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Afatinib Malate Tablets 30?mg Jiyue

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Afatinib (brand: Jiyue) is a second?generation irreversible tyrosine kinase inhibitor targeting the ErbB family (EGFR/HER2/HER4), widely used in preclinical oncology and resistance mechanism studies. Each box contains seven 30?mg film?coated tablets. Produced by Zhejiang Zhidabimi (could be mismatch, using given manufacturer Chia Tai Tianqing Pharma, China), approved under China NMPA No.?H20203715, product code 86901523002468, barcode 6922096211228.
?? For laboratory research use only.?Please consult the staff for other purposes?

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描述

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1 Afatinib Malate Product Specifications

2 Afatinib Malate Mechanism of Action

3 Afatinib Malate Research Applications & Pharmacology

4 Afatinib Malate Safety Profile & Side Effects

Afatinib Malate Product Specifications

Attribute	Details
Product Name	Afatinib Malate Tablets (Jiyue)
Generic Name	Afatinib (as malate salt)
CAS Number	850140?72?6
Molecular Formula	C??H??ClFN?O?·C?H?O?
Molecular Weight	~972?g/mol (malate salt)
Dosage Form	Film-coated oral tablet
Strength	30?mg per tablet
Pack Size	7 tablets per box
Approval Number	H20203715 (China NMPA)
Product Code	86901523002468
Manufacturer	Chia Tai Tianqing Pharma Group Co., Ltd.
Barcode	6922096211228
Storage	Store at 20–25?°C, protect from light and moisture
Intended Use	Laboratory research only

Afatinib Malate Mechanism of Action

Afatinib is an irreversible tyrosine kinase inhibitor of the ErbB family (EGFR/HER2/HER4) that blocks receptor phosphorylation, inhibiting downstream pathways (e.g., Ras/Raf/MEK/ERK, PI3K/Akt), suppressing tumor proliferation and inducing autophagy/apoptosis chemicalbook.com+12en.wikipedia.org+12selleckchem.com+12

Afatinib Malate Research Applications & Pharmacology

Oncology research: NSCLC, head & neck, breast cancer, investigating resistance mechanisms
Pathway studies: Analyze EGFR signaling, autophagy induction
Combination studies: With chemotherapy, radiotherapy, targeted agents
Preclinical dosing: ~20–60?mg/kg orally in rodents
Pharmacokinetics: Bioavailability ~92%, half-life ~37?hrs, ~95% protein-bound, metabolized not by CYP, excreted mainly fecal (85%) and urinary (4%)

Afatinib Malate Safety Profile & Side Effects

Common preclinical/clinical effects:

Rash, diarrhea, stomatitis, paronychia, fatigue
Hepatotoxicity (elevated ALT/AST in 20–50%, rare hepatic failure)
Pulmonary effects: dyspnea, rare interstitial lung disease

Handling & Storage:

Wear PPE, avoid dust/inhalation
Administer with sterile technique
Store at room temperature, dry, protected from light
Dispose according to hazardous pharmaceutical guidelines

?? Research?Use Disclaimer

This product is exclusively for laboratory research use. Not approved for diagnostic, therapeutic, or veterinary applications. Misuse may result in safety risks and unreliable outcomes.

其他信息

重量	1.1 公斤
尺寸	18 × 16 × 18 厘米

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