描述
Alarelin Acetate is an acetate salt form of a synthetic gonadotropin-releasing hormone (GnRH) agonist. It stimulates the secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), making it effective for inducing ovulation, studying sexual development, and exploring reproductive hormone regulation in animal models. Its potent efficacy has been noted in rats, mice, and fish, including delaying sexual maturation and inducing spawning. Produced in a GMP-compliant facility with ?99.90% purity—for laboratory research use only.
Product Specifications
Parameter | Details |
---|---|
Product Name | TT-232 |
Synonyms | CAP-232; TLN-232 |
CAS No. | 147159-51-1 |
Purity | ?98.27% (GMP-grade) |
Molecular Formula | C??H??N??O?S? |
Molecular Weight | ?947.13 Da |
Peptide Sequence | H–D-Phe–Cys–Tyr–D-Trp–Lys–Cys–Thr–NH? (disulfide cyclized) |
Appearance | White to off-white powder |
Solubility | Soluble to 1 mg/mL in water |
Storage Conditions | Store at –20 °C |
Manufacturing Standard | GMP-compliant production |
Applications | Somatostatin receptor research, antitumor assays, signal-transduction studies |
Regulatory Status | For laboratory research use only |
Mechanism of Action & Research Applications
Alarelin Acetate acts as a GnRH agonist, stimulating pituitary release of LH and FSH. It’s widely utilized in reproductive research for inducing ovulation in mammals and spawning in fish, and for studying sexual maturation and hormonal regulation. It also shows antitumor effects in endometrial carcinoma models. It binds GnRHR with high affinity (Kd ? 0.2 nM) and reduces tumor growth in xenograft models.
For laboratory research use only.
Side Effects (For Reference Only in Models)
In experimental models, initial GnRH receptor stimulation may lead to hormone surges followed by receptor downregulation and hypo-gonadotropic state. Anecdotal research suggests reproductive system suppression and transient hormonal imbalance.
For laboratory research use only.
Disclaimer
Alarelin Acetate is intended strictly for laboratory research use only. Not approved for human or veterinary therapy. Handle according to institutional safety guidelines.
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