Albiglutide Fragment | High Purity GLP-1 (7-36) Analog for Research

描述

Albiglutide fragment (CAS 224638-84-0) is a synthetic analog of the biologically active GLP-1 (7-36) peptide fragment, designed to mimic the activity of native glucagon-like peptide-1. It is derived from Albiglutide, a fusion protein consisting of two modified GLP-1 molecules (resistant to enzymatic degradation by DPP-4) linked to human albumin for enhanced half-life. This molecular engineering results in a fragment that retains receptor agonist activity while being highly stable in experimental settings.

With a purity of 99.86%, Albiglutide fragment represents a reliable and reproducible research-grade material. It plays a key role in studies focused on glucose homeostasis, insulin secretion, glycemic control, and long-acting peptide drug development. Research indicates that GLP-1 receptor agonists like Albiglutide fragment significantly lower blood glucose, reduce glycosylated hemoglobin (HbA1c), and may improve ?-cell function.

Because of its long half-life and receptor selectivity, Albiglutide fragment is widely utilized in type 2 diabetes mellitus (T2DM) studies, as well as in metabolic syndrome research. Its ability to mimic incretin effects while resisting enzymatic degradation makes it highly suitable for drug discovery projects investigating peptide-based antidiabetic therapies.

Manufactured under strict GMP guidelines, Albiglutide fragment is available for bulk wholesale and retail supply. The product is provided with a certificate of analysis (CoA) ensuring quality, purity, and consistency.

For laboratory research use only. Not intended for human or veterinary applications.

Product Specifications

Mechanism of Action & Research Applications

Albiglutide fragment functions as a long-acting GLP-1 receptor agonist, binding selectively to GLP-1 receptors in pancreatic ?-cells and other metabolic tissues. Upon activation, it enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety.

Unlike native GLP-1, which is rapidly degraded by the enzyme DPP-4, Albiglutide fragment is resistant to proteolytic degradation, leading to enhanced stability in research models. This allows researchers to explore the prolonged physiological effects of GLP-1 receptor activation.

Research Applications include:

• Investigating glucose regulation and insulin signaling pathways.

• Studying the reduction of HbA1c levels in type 2 diabetes models.

• Exploring ?-cell preservation and function in metabolic research.

• Testing long-acting incretin-based therapeutic strategies.

• Comparative studies with other GLP-1 receptor agonists.

By simulating incretin activity in vivo and in vitro, Albiglutide fragment enables researchers to develop novel therapeutic approaches for type 2 diabetes and metabolic disorders.

Development & Formulation Notes

The development of Albiglutide fragment was driven by the need for prolonged GLP-1 activity in metabolic research. By fusing modified GLP-1 dimers to albumin, the half-life of the peptide was extended, ensuring sustained receptor activation.

In fragment form, Albiglutide retains its essential biological activity while being easier to handle in laboratory conditions. Its high stability and solubility make it a preferred choice for experiments requiring reproducibility and consistency.

Researchers studying peptide formulation strategies can use Albiglutide fragment as a model compound for evaluating sustained-release systems, conjugation approaches, and receptor selectivity modifications.

This fragment has also been incorporated into comparative studies against native GLP-1 and other GLP-1 analogs, providing valuable insights into the pharmacodynamic advantages of peptide engineering.

Side Effects (For Reference in Research Only)

In laboratory research, GLP-1 receptor agonists including Albiglutide fragment have been associated with:

• Gastrointestinal effects (nausea, vomiting, diarrhea)

• Reduced appetite

• Delayed gastric emptying

• Potential pancreatitis (rare in models)

These findings are for research reference only and are not intended as medical advice.

Disclaimer

Albiglutide fragment is supplied strictly for laboratory research use only. It is not intended for human consumption, clinical use, diagnostic applications, or veterinary purposes.

Logistics, Packaging & Storage

• Packaging: Securely sealed in sterile, pharmaceutical-grade vials.

• Shipping: Shipped under controlled temperature conditions with full documentation.

• Storage: Store at -20°C in a dry, protected environment. Avoid repeated freeze-thaw cycles.

• Supply Options: Available for bulk wholesale and small-quantity retail. GMP-grade manufacturing ensures consistent quality for research institutions, universities, and biotech companies.

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