Alfosbuvir Tablets 100?mg (Sanoldi ) – Low price Wholesale
$1.00
Sanoldi® Alfosbuvir tablets contain 100?mg per tablet in a 42-count bottle. Developed by Nanjing Sanhe Pharmaceutical and approved under NMPA H20230010, this first-in-class NS5B polymerase inhibitor is designed for in vitro and preclinical research on hepatitis?C virus (HCV) replication and antiviral resistance.
?? For laboratory and research use only. ?Please consult staff for other specifications and uses?
描述
Alfosbuvir is a nucleotide prodrug that, once metabolized in cells, inhibits HCV NS5B RNA-dependent RNA polymerase—blocking viral replication across multiple genotypes. As China’s first domestic innovative HCV NS5B inhibitor with independent IP, it has shown promising efficacy in phase III trials—especially in combination with daclatasvir—for genotypes?1, 3, and 6, even among cirrhotic patients.
Alfosbuvir Tablets Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Alfosbuvir Tablets (Sanoldi®) |
| Generic Name | Alfosbuvir |
| CAS Number | (Not available publicly) |
| Molecular Formula | (Proprietary; nucleotide analogue) |
| Dosage Form | Oral film-coated tablet |
| Strength | 100?mg per tablet |
| Pack Size | 42 tablets per bottle |
| Approval Number | H20230010 |
| Manufacturer | Nanjing Sanhe Pharmaceutical Co., Ltd. |
| Barcode | Not yet assigned; consult pharmacist for barcode |
| Storage Conditions | Store below 30?°C, away from moisture and light |
| Intended Use | Laboratory research—HCV NS5B polymerase inhibition, antiviral assays |
Alfosbuvir Tablets Mechanism of Action
Alfosbuvir is metabolized intracellularly into a non-natural nucleotide analogue that competes with natural nucleotides during viral RNA synthesis. This terminates RNA chain extension, effectively inhibiting HCV replication. It’s considered a pan-genotypic NS5B inhibitor with a high viral suppression profile.
Alfosbuvir Tablets Research Application Areas
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Antiviral potency assays: Measuring NS5B inhibition in HCV replicon systems
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Resistance profiling: Screening for NS5B resistance-associated substitutions (RAS)
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Combination therapy models: Testing synergy with NS5A/NS3 inhibitors
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Genotype-specific studies: Especially effective in GT1/3/6 cohorts
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Pharmacokinetic / cell uptake research: Understanding prodrug activation
Safety & Handling
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Handling: Use gloves, lab coat, and eye protection; avoid direct contact
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Storage: Keep sealed below 30?°C, shielded from light and moisture
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Precautions: For in vitro or animal model use only in BSL?2 labs
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Disposal: Dispose of per institutional chemical/biomedical protocols
Core Keywords
alfosbuvir tablets, Sanoldi alfosbuvir, HCV NS5B inhibitor, nucleotide prodrug HCV, antiviral research tablets, H20230010, lab-grade alfosbuvir, pan-genotypic HCV DAA
Research Use Disclaimer
This product is intended exclusively for laboratory and preclinical research use. It is not approved for clinical, therapeutic, diagnostic, or veterinary use. Misuse may trigger legal and health consequences. Use only under approved institutional protocols.
其他信息
| 重量 | 1.2 公斤 |
|---|---|
| 尺寸 | 23 × 26 × 23 厘米 |
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