描述
Alirinetide (also known by synonyms GM-6, GM-604, GM-608) is a synthetic hexapeptide (sequence: FSRYAR) that emulates human motoneuronotrophic factor. It crosses the blood–brain barrier and displays neuroprotective effects in various models, including ALS, Parkinson’s disease, and ischemic stroke. Its actions span multiple pathways such as PI3K, insulin receptor (INSR), and c-Met modulation. Produced under GMP conditions with a purity of at least 99.73%. Intended strictly for experimental research.
Product Specifications
Parameter | Details |
---|---|
Product Name | Alirinetide |
Synonyms | GM-6; GM-602; GM-604; GM-608 |
CAS No. | 725715-18-4 |
Purity | ? 99.73% (GMP-grade) |
Molecular Formula | C??H??N??O? |
Molecular Weight | ~798.9 Da |
Sequence | FSRYAR |
Appearance | White to off-white powder |
Solubility | Soluble in water (?100 mg/mL with sonication) and DMSO |
Storage Conditions | Store at –20 °C, protected from light and moisture |
Manufacturing Standard | GMP-compliant |
Applications | Neuroprotection research, neurodegenerative disease models |
Regulatory Status | For laboratory research use only |
Mechanism of Action & Research Applications
Alirinetide modulates multiple signaling pathways, including PI3K, INSR, and c-Met, to provide neuroprotective effects in preclinical models of neurodegenerative diseases and stroke. Its ability to cross the blood–brain barrier makes it a valuable tool for neuroscientific research.
Disclaimer
This product is strictly for laboratory research use only. It is not approved for human or veterinary use. Handle according to institutional safety protocols.
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