Alsactide | CAS No. 34765-96-3

Description

Product Description

Alsactide (CAS No. 34765-96-3) is a heptadecapeptide analogue of adrenocorticotropic hormone (ACTH), designed to mimic the biological functions of endogenous ACTH while providing enhanced stability and selectivity. As an ACTH agonist, Alsactide activates the melanocortin 2 receptor (MC2R), the primary receptor responsible for stimulating the adrenal cortex to produce cortisol and other glucocorticoids.

Background and Discovery

ACTH is a pituitary hormone critical for the regulation of adrenal gland activity and plays a central role in the hypothalamic–pituitary–adrenal (HPA) axis. Dysregulation of ACTH signaling is implicated in disorders such as Addison’s disease, Cushing’s syndrome, and stress-related CNS dysfunctions. Alsactide was developed as a synthetic analogue of ACTH that preserves its receptor activity but offers better chemical stability for laboratory applications.

Structural Features

• Peptide length: Heptadecapeptide (17 amino acids)

• Core activity: Designed to mimic the functional domain of ACTH responsible for receptor binding.

• Advantages over natural ACTH:

  • Higher chemical stability

  • Resistance to enzymatic degradation

  • Reliable activation of MC2R in vitro and in vivo models

Research Significance

Alsactide is widely applied in neuroendocrinology, adrenal physiology, and CNS studies. Its ability to selectively mimic ACTH makes it a valuable tool for:

• Investigating stress response pathways

• Studying adrenal hormone regulation

• Modeling glucocorticoid release mechanisms

• Exploring CNS disorders linked to HPA axis dysfunction

Applications in Disease Research

1. Central Nervous System Studies

   • Provides insights into the role of ACTH in brain function.

   • Used in research models of stress, depression, and anxiety.

2. Adrenal Function and Hormonal Regulation

   • Stimulates adrenal cortical secretion of cortisol.

   • Applied in experimental models of hypoadrenalism and adrenal insufficiency.

3. Endocrine and Metabolic Research

   • Helps clarify the connection between ACTH activity, glucose metabolism, and immune regulation.

4. Neuroimmunology

   • Useful in studying the interaction of stress hormones and immune responses.

Product Specifications

Mechanism of Action

Alsactide acts as a selective ACTH receptor agonist. Its primary target is MC2R (melanocortin 2 receptor), which is highly expressed in the adrenal cortex.

Binding and Activation

• Receptor binding: Alsactide binds to MC2R with high affinity.

• Signal transduction: Activates Gs-protein signaling pathway.

• Downstream effect: Increases adenylate cyclase activity, elevates cAMP levels, and triggers protein kinase A (PKA) cascade.

Hormonal Effects

• Stimulates adrenal cortex to release cortisol, corticosterone, and aldosterone.

• Enhances metabolic responses to stress.

• Provides feedback regulation within the HPA axis.

CNS Relevance

• Cortisol release impacts mood, cognition, and stress adaptation.

• Alsactide serves as a research tool to probe neuroendocrine circuits.

Research Applications in Mechanistic Studies

• Stress biology: Understanding how ACTH analogues affect CNS pathways.

• Neuroendocrine disorders: Exploring altered ACTH signaling in psychiatric and neurological conditions.

• Metabolism: Linking glucocorticoid signaling to energy balance and glucose homeostasis.

  

Side Effects

Although used exclusively in research, Alsactide’s biological profile suggests potential effects:

Endocrine Effects

• Excess glucocorticoid production in models may cause Cushing-like symptoms.

• Long-term exposure may disrupt HPA axis homeostasis.

Metabolic Effects

• Altered glucose levels due to cortisol elevation.

• Possible weight gain in animal models with chronic exposure.

CNS Effects

• Behavioral changes linked to cortisol fluctuations.

• Potential for anxiety or mood alterations in sensitive systems.

Gastrointestinal and Systemic Effects

• Appetite modulation observed in experimental animals.

• Possible changes in immune response due to glucocorticoid activity.

Laboratory Safety Notes

• For research use only, not for human administration.

• Peptide handling requires gloves and protective lab conditions.

Disclaimer

Alsactide is supplied strictly for laboratory research use only. It is not approved for clinical, diagnostic, or therapeutic applications.

Keywords

Alsactide, CAS 34765-96-3, ACTH agonist, heptadecapeptide, adrenal cortex research, CNS peptide, neuroendocrine model, melanocortin 2 receptor, HPA axis, glucocorticoid secretion.

Shipping Guarantee

We provide global secure shipping with:

• Customs-cleared delivery worldwide

• Compensation for loss or damage in transit

• Fast, trackable international courier options

Transaction Guarantee

We support multiple safe and convenient payment options:

• Bank Transfer (T/T)

• PayPal

• Cryptocurrency (BTC, ETH, USDT, etc.)

• Flexible options on request