Amifostine Injection – Lyophilized Powder Vial
$1.00
Amifostine Injection (ZeTong®) is a sterile lyophilized powder of amifostine—a cytoprotective agent used to reduce chemotherapy- and radiotherapy-induced toxicity (e.g., nephrotoxicity and xerostomia). Packaged as a 0.5?g vial, the product is manufactured by Kaifeng Mingren Pharmaceutical Co., Ltd. (NMPA No. H20227121; Code 86907462000084; barcode 6952930000039). Strictly for laboratory research use?Please consult the staff for other purposes.
描述
Amifostine Injection Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Amifostine Injection (ZeTong®) |
| Generic Name | Amifostine |
| Dosage Form | Lyophilized Powder for Injection |
| Strength | 0.5g per vial |
| Packaging | 1 vial per box |
| Approval Number | China NMPA H20227121 |
| Product Code | 86907462000084 |
| Manufacturer | Kaifeng Mingren Pharmaceutical Co., Ltd. |
| CAS Number | 20537-88-6 |
| Molecular Formula | C?H??N?O?PS (anhydrous) |
| Molecular Weight | ~214.2g/mol |
| Storage | Store at 20–25°C; protect from light |
| Barcode | 6952930000039 |
| Intended Use | Laboratory research only — Not for clinical or veterinary use |
Amifostine Injection Mechanism of Action
Amifostine is a prodrug that is converted by alkaline phosphatase into the active free thiol metabolite WR1065, which selectively protects healthy tissues by scavenging free radicals and detoxifying reactive metabolites. This protects against renal toxicity from agents like cisplatin and oral mucosal damage from head/neck radiotherapy sciencedirect.com+7en.wikipedia.org+7accessdata.fda.gov+7.
Amifostine Injection Dosage & Administration (Research Context)
Although approved clinical doses start at 200 mg/m² for radioprotection and 740–910 mg/m² for chemoprotection, laboratory use should be guided by study protocol and safety standards. For reference: 910?mg/m² is given as a 15?minute IV infusion ~30?min before chemotherapy pubchem.ncbi.nlm.nih.gov+2pubmed.ncbi.nlm.nih.gov+2sciencedirect.com+2.
Key Safety Considerations
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Hypotension, nausea/vomiting, and hypocalcemia are common adverse effects
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Monitoring of blood pressure and hydration status is critical during administration
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Handle as a cytoprotective agent; use PPE and follow biosafety guidelines.
Research Applications
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Chemoradioprotection assays in preclinical models
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Investigations on oxidative stress and DNA repair pathways
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Pharmacokinetics/pharmacodynamics modeling via WR?1065
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Comparative studies using chemoprotective agents
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In vitro / in vivo testing of adjunctive therapies
Research Use Disclaimer
This product is for laboratory research and development use only. Not intended for clinical, diagnostic, therapeutic, or veterinary use.
其他信息
| 重量 | 1.1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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