Description
Amisulpride is a selective D2/D3 dopamine receptor antagonist used extensively in behavioral pharmacology and CNS-focused research. This oral formulation allows flexible dosing for animal studies, making it suitable for long-term administration in research settings involving schizophrenia, bipolar disorder, or dopamine modulation.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Amisulpride Oral Solution |
| Generic Name | Amisulpride |
| CAS Number | 71675-85-9 |
| Molecular Formula | C??H??N?O?S |
| Molecular Weight | 369.48?g/mol |
| Formulation | Oral liquid (solution) |
| Strength | 6?g per 60?ml (100?mg/ml) |
| Packaging | Bottle with measuring cup |
| Dosage Form | Oral Solution |
| Pack Size | 1 bottle per box |
| Approval Number | H20233767 (NMPA China) |
| Drug Code | 86981979000140 |
| Manufacturer | Zhejiang CONBA Pharmaceutical Co., Ltd. |
| Storage Conditions | Store below 25?°C, protect from light |
| Intended Use | Laboratory research only |
Mechanism of Action
Amisulpride selectively blocks dopamine D2 and D3 receptors, especially in the limbic system. At low doses, it modulates presynaptic autoreceptors to increase dopamine release, while at high doses, it reduces postsynaptic signaling—making it unique among antipsychotics for dose-dependent action. It does not bind significantly to serotonin or muscarinic receptors.
Research Applications
Schizophrenia Models
Assesses antipsychotic efficacy, dopaminergic modulation, and cognitive function in rodent models of psychosis.Bipolar Disorder & Mood Stabilization
Studied in models involving manic-like behavior and dopaminergic hyperactivity.Cognitive & Reward Studies
Useful for experiments involving working memory, reward processing, and behavioral inhibition.PET Imaging & Receptor Binding Studies
D2 receptor occupancy and pharmacokinetics evaluation.Dose-Response Pharmacology
Oral liquid format ideal for titration studies in various animal species.
Safety Profile & Handling
Common Lab Observations: Hypoactivity, weight changes, and mild GI effects in high doses.
Toxicity: Low acute toxicity; avoid overdose in small animal models.
Handling: Use with gloves in biosafety cabinets. Avoid ingestion or contact with skin.
Shelf Life: 24 months in original sealed packaging.
Core Keywords
Amisulpride oral solution, CAS 71675-85-9, dopamine D2 D3 antagonist, schizophrenia research, antipsychotic for lab use, Amisulpride liquid form, CNS pharmacology, wholesale Amisulpride, lab-grade antipsychotics
Research-Use Disclaimer
This product is supplied strictly for laboratory research use only. It is not approved for human consumption, diagnostic, therapeutic, or veterinary purposes. Use only under institutional biosafety guidelines and proper handling procedures.


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