Amphomycin – High Purity Lipopeptide Antibiotic for Research

描述

Amphomycin (CAS No. 1402-82-0) is a naturally occurring lipopeptide antibiotic first discovered for its broad-spectrum antibacterial properties. Its chemical structure includes a lipid tail conjugated to a peptide core, allowing it to integrate into bacterial membranes and interfere with cell wall biosynthesis. Amphomycin primarily inhibits the formation of peptidoglycan, a critical polymer that maintains bacterial cell wall integrity, thereby preventing bacterial proliferation and inducing bactericidal effects.

The mode of action of Amphomycin is highly selective for Gram-positive bacteria, particularly those with multi-drug resistance profiles. It demonstrates potent antibacterial activities against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), penicillin-gentamicin-erythromycin-resistant Streptococcus pneumoniae, and linezolid-quinupristin-dalfopristin-resistant enterococci. This unique spectrum positions Amphomycin as a critical molecule in preclinical antibiotic research and drug development studies.

Amphomycin’s lipopeptide structure facilitates strong membrane interaction, enhancing its antibacterial efficacy while minimizing off-target effects in bacterial research models. The compound is supplied as a lyophilized powder, maintaining stability under controlled storage conditions, ensuring reproducibility and reliability in experimental protocols.

Produced under GMP standards,  comes with a certified purity of 97.28%, making it suitable for advanced microbiology, infectious disease, and pharmacology research. Its stability profile allows storage at -20°C under inert atmosphere, with protection from moisture and light. Amphomycin is available for both wholesale and retail, enabling research laboratories and institutions to access high-quality material for in vitro and in vivo investigations.

Laboratory Use Only:  is not intended for human or veterinary use. All handling should follow appropriate biosafety and chemical safety protocols.

Product Specifications

Mechanism of Action & Research Applications

Amphomycin is a highly selective lipopeptide antibiotic that exerts its antibacterial effect through inhibition of peptidoglycan biosynthesis. Peptidoglycan, a polymer of sugars and amino acids, provides structural rigidity to bacterial cell walls. By blocking its synthesis, Amphomycin compromises the structural integrity of Gram-positive bacteria, leading to cell lysis.

Mechanism of Action

• Peptidoglycan Inhibition: Amphomycin binds to the lipid II intermediate, an essential component in cell wall biosynthesis, preventing incorporation into the growing peptidoglycan chain.

• Membrane Interaction: Its lipid tail anchors into bacterial membranes, disrupting membrane-associated processes essential for cell wall assembly.

• Bactericidal Activity: Inhibition of peptidoglycan synthesis leads to cell wall destabilization, resulting in bacterial death.

• Selective Targeting: Amphomycin preferentially targets Gram-positive bacteria and multi-drug resistant strains, while exhibiting minimal interaction with mammalian membranes in controlled experimental models.

Research Applications

Amphomycin is widely applied in preclinical and laboratory research for multiple purposes:

1. Antibiotic Resistance Studies: Evaluation of mechanisms behind MRSA, VRE, and resistant S. pneumoniae, enabling the development of next-generation antibacterial therapies.

2. Microbiology and Infectious Disease Models: Amphomycin is used to model bacterial infections and test antimicrobial efficacy in vitro and in vivo.

3. Cell Wall Biosynthesis Research: Investigations into peptidoglycan assembly, lipid II dynamics, and bacterial membrane processes.

4. Drug Development: Screening potential derivatives and conjugates to overcome multi-drug resistant bacterial strains.

5. Synergistic Studies: Evaluating Amphomycin in combination with other antibiotics to study synergistic effects and optimize therapeutic strategies.

This compound’s unique lipopeptide structure offers insight into novel antibacterial mechanisms and has inspired design of structurally related synthetic antibiotics for resistant pathogens.

Side Effects (For Reference in Models)

In experimental models, Amphomycin demonstrates specific biological effects tied to its mechanism of action:

• Membrane Interaction: Potential for disruption of bacterial membranes, which is desired for antibacterial research but requires caution in model selection.

• Cytotoxicity Assessment: Amphomycin may affect bacterial cell viability rapidly; dose-dependent cytotoxicity should be carefully monitored in culture studies.

• Resistance Selection Pressure: Prolonged exposure in microbial cultures can lead to selection of resistant strains, which is a key factor in experimental design.

• Off-Target Effects: Minimal in mammalian cells under controlled laboratory conditions, but careful in vitro testing is recommended.

Researchers should follow standard laboratory safety procedures, use appropriate containment, and avoid any human or veterinary administration.

Disclaimer

 is supplied exclusively for laboratory research use. It is not intended for human or veterinary consumption. All experiments should be conducted under appropriate biosafety protocols.

Keywords

•  CAS 1402-82-0

• Lipopeptide antibiotic research

• VRE research compound

• Multi-drug resistant bacteria research

• Buy Amphomycin wholesale