Description

Product Description

Anastrozole is a synthetic triazole derivative that functions as a selective, reversible inhibitor of the aromatase enzyme (CYP19A1), which catalyzes the conversion of androgens to estrogens. Unlike steroidal aromatase inhibitors, anastrozole does not irreversibly bind to the enzyme but competitively inhibits its activity, providing a model for studying reversible enzyme inhibition and hormone regulation.

In preclinical research, anastrozole is employed to explore:

• The molecular mechanisms of estrogen synthesis inhibition.

• Effects on estrogen-dependent cell proliferation and gene expression.

• Comparative studies of steroidal versus non-steroidal aromatase inhibitors.

• Pharmacokinetic modeling of reversible enzyme inhibition.

Structurally, anastrozole’s triazole ring interacts with the heme group of aromatase, preventing substrate binding. This selective inhibition reduces estradiol and estrone production in model systems, enabling researchers to study estrogen-sensitive cellular processes, transcriptional regulation, and endocrine feedback loops.

Anastrozole is also utilized in combination studies with other biochemical agents to evaluate synergistic effects on hormone metabolism, cell cycle regulation, and signal transduction pathways. Its high specificity and minimal off-target activity make it a standard reference compound in laboratory studies of estrogen biosynthesis and endocrine disruption.

Product Specifications

Mechanism of Action

Anastrozole functions as a reversible, non-steroidal inhibitor of aromatase (CYP19A1). By binding competitively to the heme iron within the enzyme, it prevents the conversion of androgens (testosterone and androstenedione) into estrogens (estradiol and estrone). This reduces estrogen availability in endocrine-sensitive systems.

1. Aromatase Inhibition

Anastrozole’s triazole moiety chelates the heme iron in aromatase, inhibiting catalytic activity without covalent modification. This reversible binding allows researchers to study time- and concentration-dependent enzyme inhibition.

2. Downstream Molecular Effects

Reduction in estrogen synthesis leads to decreased activation of estrogen receptors (ERα, ERβ) in target cells. This affects transcriptional regulation of estrogen-responsive genes involved in cell proliferation, apoptosis, and differentiation.

3. Experimental Applications

• Modeling hormone-dependent cancer growth.

• Investigating feedback loops in endocrine regulation.

• Comparative analysis of non-steroidal versus steroidal aromatase inhibitors.

• Evaluating effects on estrogen-mediated transcription and cell signaling in vitro.

  

Side Effects

At research concentrations, anastrozole is generally well-tolerated in laboratory models. Possible effects include:

• Dose-dependent inhibition of estrogen-sensitive cell proliferation.

• Modulation of hormone-responsive gene expression.

• Potential oxidative stress in sensitive cell lines at high concentrations.

These effects are strictly experimental and observed under controlled laboratory conditions. The compound is not intended for human or veterinary use.

Keywords

Anastrozole, CAS 120511-73-1, non-steroidal aromatase inhibitor, CYP19A1 research, estrogen biosynthesis inhibition, endocrine research chemical, hormone-sensitive cancer model, reversible enzyme inhibitor, high-purity research compound, research chemical manufacturer, OEM & bulk production China.

Shipping Guarantee

All Anastrozole shipments are handled using validated cold-chain logistics to preserve compound integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Anastrozole ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Anastrozole provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Anastrozole products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.