描述
Product Specifications
Attribute | Details |
---|---|
Product Name | Anastrozole Tablets (Yishuzhi®) |
Generic Name | Anastrozole |
CAS Number | 120511?73?1 :contentReference[oaicite:5]{index=5} |
Molecular Formula | C??H??N? :contentReference[oaicite:6]{index=6} |
Molecular Weight | 293.37?g/mol :contentReference[oaicite:7]{index=7} |
Dosage Form | Film-coated oral tablet |
Strength | 1?mg per tablet |
Pack Size | 28 tablets per box |
Approval Number | H20133110 (China NMPA) |
Product Code | 86904641003065 |
Manufacturer | Zhejiang Hisun Pharmaceutical Co., Ltd. |
Barcode | 6939030230917 |
Storage | Store at room temperature; protect from moisture |
Intended Use | Laboratory research only |
Mechanism of Action
Anastrozole reversibly inhibits aromatase (CYP19), blocking conversion of androgens to estrogens, resulting in ?96% aromatase inhibition at 1?mg/day and an ~85% reduction in circulating estradiol news.qq.com+14en.wikipedia.org+14go.drugbank.com+14.
Research Applications & Pharmacology
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Breast cancer research: hormone-dependent growth, estrogen receptor modulation
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Endocrine pathway studies: estrogen synthesis, aromatase activity assays
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Pharmacokinetics: Protein binding ~40%, hepatic metabolism (~85%), t½ 40–50?hrs, renal excretion <11%
Safety Profile & Common Adverse Effects
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Clinical observations: hot flashes, fatigue, joint pain, nausea, headache, bone mineral density loss, mood disturbances, elevated liver enzymes
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Handling notes: wear PPE, store tablets properly, report signs of hormonal modulation in animal models
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Contraindications: not for pregnancy, premenopausal uterine bleeding, severe hepatic/renal impairment
?? Research?Use Disclaimer
This product is exclusively for laboratory research use and is not approved for therapeutic, diagnostic, clinical, or veterinary use. Misuse may pose safety risks and invalidate research findings.
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