Description

Angiotensin II Human TFA (CAS 2761969-44-0), also known as DRVYIHPF TFA, is a synthetic peptide hormone that serves as a potent vasoconstrictor and a major bioactive peptide of the renin-angiotensin system. It plays a central role in regulating blood pressure by interacting with G-protein-coupled receptors, specifically the Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R).

This peptide stimulates sympathetic nervous activity, increases aldosterone biosynthesis, and enhances renal actions. Additionally, it promotes the growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II Human TFA also induces apoptosis and capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway.

Synthetized under GMP conditions, this product boasts a purity of ?98.84%, ensuring high-quality standards for laboratory applications.

Product Specifications

Mechanism of Action & Research Applications

Angiotensin II Human TFA functions as an agonist at both AT1 and AT2 receptors, mediating various physiological effects. It induces vasoconstriction, stimulates aldosterone release, and modulates sympathetic nervous activity. These actions are pivotal in regulating blood pressure and fluid balance.

In laboratory research, this peptide is utilized to study the renin-angiotensin system’s role in cardiovascular health, fibrosis, and endothelial cell function. Its high purity and GMP synthesis make it suitable for various in vitro and in vivo experiments.

Disclaimer

This product is intended strictly for laboratory research use only. It is not approved for human or veterinary use. Handle according to institutional safety protocols.