Apomorphine Hydrochloride Sublingual Tablets 3?mg
$2.00
Apomorphine hydrochloride is a rapid?acting dopamine agonist used in Parkinson’s disease research to treat acute “off” episodes. These 3?mg sublingual tablets dissolve under the tongue for quick absorption, making them ideal for laboratory and preclinical studies. Not approved for therapeutic, diagnostic, clinical, or veterinary use.?Please consult staff for other specifications and uses?
描述
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Apomorphine Hydrochloride Sublingual Tablets |
| Generic Name | Apomorphine Hydrochloride (hemihydrate) |
| CAS Number | 41372?20?7 |
| Molecular Formula | C??H??NO? · HCl · ½H?O |
| Molecular Weight | ~312.8?g/mol |
| Dosage Form | Sublingual tablet (film/tablet) |
| Strength | 3?mg per tablet |
| Pack Size | 1 tablet per box |
| Approval No. | China NMPA H20050970 |
| Product Code | 86901828000640 |
| Manufacturer | Hubei Keyi Pharmaceutical Co., Ltd. |
| Barcode | 6938399500952 |
| Storage Conditions | Store at 15–25?°C in a cool, dry place |
| Intended Use | Laboratory and preclinical research only |
Mechanism of Action
Apomorphine is a non-selective dopamine agonist with high affinity for D?–D? receptors and some serotonergic and adrenergic receptor activity. It mimics dopamine, alleviating motor “off” episodes in Parkinson’s disease models .
Research Applications & Pharmacology
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Parkinson’s Disease (PD) Models: Used to manage acute motor “off” episodes with rapid onset (~10–20 min), mimicking dopaminergic therapy .
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Pharmacokinetics & Comparison: Sublingual film/tablet provides similar efficacy to subcutaneous injection; widely preferred by patients in comparative studies pmc.ncbi.nlm.nih.gov+1en.wikipedia.org+1.
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Dose Titration: Standard clinical initiation begins at 10?mg, optimized to 15–30?mg sublingually; research-grade 3?mg tablets can be used for precise titration .
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Additional Research Use: Investigated for erectile function modulation, addiction treatment, Alzheimer’s disease, and vomiting induction in veterinary models .
Safety Profile & Handling
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Common Side Effects: Nausea (often requiring antiemetics), orthostatic hypotension, somnolence, dizziness, dyskinesia .
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Cardiac Effects: May cause QT prolongation—monitor cardiovascular parameters in research .
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Drug Interactions: Potentiates hypotension with nitrates/vasodilators; alcohol and dopamine antagonists may reduce efficacy or increase side effects .
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Handling Recommendations: Store protected from light and moisture; use PPE and lab-standard precautions. Discard expired items per institutional protocol.
其他信息
| 重量 | 1 公斤 |
|---|---|
| 尺寸 | 18 × 16 × 18 厘米 |
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