Description

Argadin (CAS No. 289665-92-5) is a cyclic pentapeptide-derived natural product recognized for its potent inhibition of family-18 chitinases, particularly chitinase B (ChiB), with an inhibition constant (Ki) of approximately 20 nM. Produced by fungal strains such as Clonostachys sp. FO-7314, Argadin displays promise in research applications involving chitinase function, fungal pathogenesis, and insect development pathways. Manufactured under GMP conditions ensuring purity (98.71%), this compound supports reliable and reproducible experimental outcomes. Strictly for in-vitro research use only.

Product Specifications

Mechanism of Action & Research Applications

Argadin is a cyclopentapeptide that acts as a nanomolar-level inhibitor of family-18 chitinases, notably chitinase B (ChiB), by binding tightly to the enzyme’s active site. Structural and enzymological studies reveal that Argadin’s cyclic backbone mimics the transition state of chitooligosaccharide substrates, offering stronger inhibition than classical carbohydrate-based inhibitors like allosamidin.

Key Research Uses:

• Fungal Biology & Pathogenesis: Enables the study of chitinase-driven cell wall degradation mechanisms.

• Agricultural & Insect Studies: Can probe the role of chitinases in insect molting and development.

• Structural Enzymology & Drug Design: Serves as a template for designing more potent chitinase inhibitors.

• Biochemical Assays: Useful in screening and mechanistic studies of chitinase function.

  

Side Effects (For Research Reference Only)

Argadin is intended for in vitro research only. There is no available data regarding effects in animal or human use. Standard laboratory safety protocols should be followed.

Disclaimer

Argadin is strictly for laboratory research use only. It is not approved for any form of therapeutic or clinical use. Handle following institutional safety guidelines.