Argireline acetate | CAS No. 2484708-86-1

Description

Product Description

Argireline acetate (CAS 2484708-86-1), also called Acetyl hexapeptide-3 acetate, is a synthetic bioactive peptide derived from SNAP-25 (synaptosomal-associated protein) fragments. It has become one of the most widely researched and commercially recognized peptides in anti-aging and cosmeceutical applications, particularly for its role in reducing facial dynamic wrinkles without invasive procedures.

Scientific Background

Wrinkle formation is driven by multiple factors, including:

• Repeated facial muscle contractions mediated by acetylcholine release.

• Loss of skin elasticity due to collagen and elastin degradation.

• Environmental stress such as UV exposure and oxidative damage.

• Intrinsic aging processes including reduced fibroblast activity.

Botulinum toxin (Botox®) has traditionally been used to inhibit neuromuscular transmission and smooth dynamic wrinkles. However, Botox requires injections, which carry risks and patient discomfort. Argireline acetate provides a non-invasive, topical alternative by mimicking part of the SNAP-25 protein and inhibiting vesicle fusion at the neuromuscular junction, thereby reducing acetylcholine release.

Mechanistic Significance

By blocking the SNARE complex assembly, Argireline acetate reduces neurotransmitter secretion, leading to decreased muscle contraction intensity. This mechanism makes it a “Botox-like” peptide, but with the advantages of safety, reversibility, and topical applicability.

Research Applications

• Cosmeceutical Research – Formulation of antiwrinkle creams, serums, and topical agents.

• Skin Aging Studies – Evaluation of dermal elasticity, wrinkle depth, and collagen content.

• Neuromuscular Biology – As a tool to study neurotransmitter exocytosis pathways.

• Combination Therapy Research – Studying synergistic effects with antioxidants, hyaluronic acid, and collagen boosters.

Comparative Advantages

• Non-toxic and skin-permeable.

• Topical activity eliminates the need for injections.

• Reversible effects without long-term neuromuscular compromise.

• Applicable across diverse skin types.

Argireline acetate has become a gold standard peptide in cosmetic peptide research, particularly within anti-aging innovation.

Product Specifications

Extended Notes on Specifications

• Production Method: Synthesized via SPPS with high sequence fidelity.

• Quality Testing: Confirmed with MS, HPLC, and amino acid composition.

• Formulation: Suitable for incorporation into aqueous or cream-based research formulations.

• Experimental Use: Widely studied in topical skin penetration models and wrinkle reduction assays.

• Comparisons: Demonstrates faster visible results in wrinkle reduction compared to many antioxidant-only formulations.

Mechanism of Action

Argireline acetate functions primarily through neuromodulation at the neuromuscular junction, mimicking the N-terminal end of SNAP-25, a critical SNARE complex protein.

Stepwise Mechanism

1. Competition with SNAP-25
   Argireline acetate competes with endogenous SNAP-25 for incorporation into the SNARE complex.

2. Disruption of SNARE Assembly
   Prevents the full assembly of the vesicle fusion machinery needed for neurotransmitter release.

3. Inhibition of Acetylcholine Release
   Reduces Ca²⁺-dependent exocytosis of acetylcholine at the presynaptic terminal.

4. Decreased Muscle Contraction
   Less acetylcholine leads to reduced stimulation of muscle fibers, thereby lowering contraction frequency and intensity.

5. Wrinkle Reduction
   Over time, decreased muscle movement lessens the depth and visibility of facial expression lines.

Additional Biological Insights

• Anti-inflammatory Effects: May indirectly reduce skin inflammation associated with repetitive mechanical stress.

• Collagen Preservation: Reduced mechanical strain decreases collagen breakdown in dermal tissues.

• Synergistic Action: When combined with other peptides (e.g., Matrixyl®) or antioxidants, efficacy improves significantly.

This dual action—neuromuscular inhibition and dermal preservation—positions Argireline acetate as a highly effective anti-aging research peptide.

Side Effects

Research Observations

• Argireline acetate is generally non-toxic and well-tolerated in experimental models.

• Demonstrates excellent skin permeability with minimal irritation.

• No systemic neuromuscular compromise observed in topical use models.

Potential Limitations

• Concentration-Dependent Activity: Higher concentrations may cause transient skin tightness.

• Short Biological Half-life: Requires repeated applications in topical studies.

• Stability Issues: Sensitive to oxidative degradation in aqueous formulations if not stabilized.

Laboratory Precautions

• For research use only, not for therapeutic applications.

• Store under appropriate conditions to maintain integrity.

• Formulate with stabilizers (antioxidants, chelating agents) for long-term research use in solution.

Overall, Argireline acetate remains one of the safest peptides investigated in cosmetic science.

Disclaimer

This product is for research use only. Not intended for human medical use, diagnosis, treatment, or therapeutic application.

Keywords

Argireline acetate, CAS 2484708-86-1, acetyl hexapeptide-3 acetate, antiwrinkle peptide, cosmetic peptide, anti-aging peptide, neurotransmitter inhibitor peptide, Botox-like peptide, skin permeable peptide.

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