描述
Atorvastatin calcium is a lipid-lowering agent that inhibits HMG-CoA reductase, a key enzyme in cholesterol biosynthesis. It is extensively studied for its role in reducing low-density lipoprotein cholesterol (LDL-C), preventing cardiovascular diseases, and regulating lipid metabolism.
This product contains 20mg atorvastatin calcium per tablet, supplied as 7 tablets per box. It is primarily used in research models investigating cholesterol metabolism, atherosclerosis, and cardiovascular pharmacology.
Manufactured by Shandong Xinhua Pharmaceutical Co., Ltd., with China NMPA approval number H20213751 and product code 86904494003106.
?? For laboratory research use only. Not for human or veterinary use.
Product Specifications
Parameter | Details |
---|---|
Product Name | Atorvastatin Calcium Tablets (Xinketuo/Xinhua) |
Generic Name | Atorvastatin Calcium |
CAS Number | 134523-03-8 |
Molecular Formula | C33H34FN2O5·Ca |
Molecular Weight | 1209.42 g/mol (calcium salt) |
Dosage Form | Tablet |
Strength | 20mg per tablet |
Quantity | 7 tablets per box |
Approval Number | H20213751 (China NMPA) |
Product Code | 86904494003106 |
Manufacturer | Shandong Xinhua Pharmaceutical Co., Ltd. |
Barcode | 6921675342094 |
Intended Use | Laboratory research only |
Storage Conditions | Store sealed, below 25°C, away from moisture and light |
Mechanism & Research Applications
Atorvastatin calcium acts by competitively inhibiting HMG-CoA reductase, the enzyme responsible for converting HMG-CoA to mevalonate, a precursor of cholesterol. This results in decreased cholesterol synthesis in the liver and upregulation of LDL receptors, promoting clearance of LDL cholesterol from the bloodstream.
In research, atorvastatin is used to study lipid metabolism, cardiovascular disease mechanisms, atherosclerosis development, and anti-inflammatory effects related to statin therapy. It is also employed in pharmacodynamic and pharmacokinetic studies of cholesterol-lowering agents.
Safety & Handling
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Use Restriction: For laboratory research use only; not for clinical, diagnostic, or veterinary applications.
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Protective Equipment: Gloves, lab coat, and eye protection recommended during handling.
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Storage: Keep sealed and store below 25°C, protected from humidity and direct sunlight.
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Disposal: Follow institutional and environmental safety guidelines for chemical waste disposal.
Research Use Disclaimer
This product is exclusively for laboratory research. It is not approved for therapeutic, diagnostic, or veterinary applications. Any misuse may result in health or legal risks. Always adhere to institutional safety and handling protocols.
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