Aureobasidin A (CAS: 123334-87-6) – Purity 99.36% | GMP Factory

描述

Aureobasidin A, also known as Basifungin, is a cyclic depsipeptide antibiotic known for its strong antifungal and antiparasitic properties. It acts by inhibiting the inositol phosphoryl ceramide (IPC) synthase AUR1, an essential enzyme in fungal sphingolipid biosynthesis. This mechanism makes it highly effective against various fungal pathogens, including Candida and Cryptococcus species.

Due to its unique mode of action and oral bioactivity, Aureobasidin A is extensively utilized in fungal pathogenesis, membrane biology, and lipid metabolism research.

This product is manufactured in a GMP-compliant facility ensuring exceptional purity and batch-to-batch consistency. It is strictly for research use only and is not intended for human or veterinary applications.

Product Specifications

Mechanism of Action & Research Applications

Aureobasidin A inhibits IPC synthase AUR1, an essential enzyme in the biosynthetic pathway of complex sphingolipids in fungal cells. This inhibition disrupts the integrity of the fungal cell membrane, leading to apoptosis and growth inhibition.

Research Applications:

• Antifungal mechanism exploration

• Study of sphingolipid metabolism

• Target validation in fungal infections

• Membrane structure-function studies

• Antiparasitic screening platforms

• Drug resistance model development

Side Effects

In research environments, the following effects have been observed:

• Dose-dependent membrane disruption in fungal cells

• Cytotoxicity at high concentrations in non-target organisms

• Minimal off-target activity in mammalian systems

All observed effects are strictly research-contextual and dependent on experimental design.

Disclaimer

This product is for research use only. It is not intended for clinical, diagnostic, therapeutic, or human consumption. Manufactured in a GMP-compliant environment to ensure quality and purity for scientific research purposes only.