Description

Product Description

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG is a synthetic osteogenic peptide that promotes bone ossification by activating signaling pathways involved in osteoblast differentiation, matrix mineralization, and bone remodeling. The inclusion of α-aminoisobutyric acid (Aib) within its sequence enhances peptide stability and conformational rigidity, improving its bioactivity and resistance to enzymatic degradation.

This peptide has demonstrated the ability to stimulate osteoblast proliferation, increase alkaline phosphatase (ALP) activity, and upregulate bone matrix proteins such as osteocalcin and collagen type I. These biological actions make it a valuable tool for research on osteogenic differentiation and osteoporosis treatment development.

Biological Significance

Bone formation and resorption are finely balanced processes regulated by osteoblasts and osteoclasts. In conditions like osteoporosis, osteogenesis imperfecta, and age-related bone loss, this balance is disrupted, leading to decreased bone mass and fragility.

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG functions as an anabolic peptide that promotes bone formation through multiple mechanisms:

• Enhancing osteoblast differentiation from mesenchymal stem cells (MSCs)

• Upregulating transcription factors such as RUNX2 and Osterix

• Increasing mineral deposition via calcium-phosphate crystal formation

• Reducing oxidative stress and apoptosis in bone-forming cells

These combined effects support its use as a research peptide for bone regeneration and metabolic bone disorders.

Experimental Applications

• Osteogenesis research – investigation of bone formation signaling pathways

• Osteoporosis models – study of peptide-induced increases in BMD

• Tissue engineering – incorporation into scaffolds or hydrogels to promote bone repair

• Pharmacological studies – exploration of bone anabolic agents and peptide-based therapeutics

The peptide’s design featuring the Aib residue confers a helical conformation, which mimics natural bone growth factors and enhances receptor binding affinity, making it suitable for preclinical investigations of peptide-mediated osteoregulation.

Product Specifications

Synonyms

• Osteogenic Peptide AVSEHQLLHDKGKSIQDLRRRFFLHHLI-Aib-EIHTAYRFGG

• BMD-Stimulating Peptide

• Synthetic Osteoactive Peptide

Mechanism of Action

The osteogenic effect of AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG is mediated through activation of bone anabolic signaling pathways and enhancement of osteoblast function.

1. BMP and Wnt Signaling Activation

The peptide activates bone morphogenetic protein (BMP) signaling, leading to increased expression of Smad1/5/8 and RUNX2, critical transcription factors for osteoblast differentiation. Concurrently, it stimulates Wnt/β-catenin signaling, reinforcing bone matrix gene expression and calcium deposition.

2. Promotion of Osteoblast Differentiation

By increasing ALP activity and osteocalcin secretion, the peptide supports early and late stages of osteogenesis. The presence of Aib helps stabilize the peptide in an α-helical conformation that mimics natural BMP peptides, enhancing receptor affinity.

3. Suppression of Osteoclastogenesis

The peptide downregulates RANKL expression and promotes osteoprotegerin (OPG) synthesis, thus reducing osteoclast-mediated bone resorption. This dual action preserves bone mass and prevents bone loss.

4. Mineralization Enhancement

Through direct stimulation of calcium phosphate crystal nucleation, the peptide accelerates matrix mineralization. In vitro studies show increased hydroxyapatite deposition in cultured osteoblasts treated with the peptide.

5. Potential for Bone Repair

When combined with biomaterials, AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG enhances osseointegration and bone scaffold performance, offering potential applications in orthopedic and dental regenerative research.

Side Effects

In experimental settings, the peptide is biocompatible and non-toxic. However, researchers should consider the following precautions:

• Concentration-dependent responses: Excessive peptide concentrations may cause osteoblast overstimulation.

• In vitro cytotoxicity: Minimal cytotoxicity at high doses (>50 μM).

• Not for clinical use: The peptide is for research use only.

No systemic toxicity or immunogenicity has been reported in preclinical models.

Disclaimer

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG is intended for laboratory research use only. It is not approved for human or animal therapeutic use. Data provided are for research and educational reference.

Keywords

AVSEHQLLHDKGKSIQDLRRRFFLHHLI Aib EIHTAYRFGG, osteogenic peptide, bone ossification peptide, bone regeneration, osteoporosis research peptide, BMD peptide, bone mineral density enhancement, osteoblast differentiation peptide, bone repair peptide, α-aminoisobutyric acid modified peptide.

Shipping Guarantee

All peptides are shipped under low-temperature and vacuum-sealed conditions, ensuring purity and structural stability. Analytical data (HPLC and MS) are provided with each shipment.

Transaction Guarantee

Every batch includes a Certificate of Analysis (COA) verifying purity and molecular integrity. We ensure full replacement or refund for quality deviations or shipping damage.