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Bevonescein (ALM-488) is a synthetic fluorescein-conjugated peptide (GMP-grade) used in research to label intact and degenerated peripheral nerves via real-time fluorescence imaging. Available for wholesale and retail; for laboratory research use only.?For wholesale prices, other specifications and uses, please consult our staff?
Bevonescein, also known as ALM-488 (CAS 2276787-79-0), is a fluorescein-conjugated peptide-dye tracer designed to bind nerve-associated connective tissue. It enables both intact and degenerated peripheral nerves to fluoresce during real-time imaging—particularly useful in surgical fluorescence-guided models.
Preclinical studies confirm that Bevonescein offers superior visualization of degenerated facial nerves compared to traditional myelin-binding dyes, greatly improving surgical nerve identification in animal models.
Synthesized under GMP conditions, Bevonescein offers high purity and consistent quality for research applications in neuroscience and surgical visualization.
| Parameter | Details |
|---|---|
| Product Name | Bevonescein (ALM-488) |
| Synonyms | ALM-488 |
| CAS No. | 2276787-79-0 |
| Purity | High-purity (GMP-grade) |
| Molecular Formula | C???H???N??O?? |
| Molecular Weight | ~2310.5 Da |
| Appearance | White to off-white solid |
| Solubility | Soluble in DMSO (approx. 100 mg/mL) with ultrasonication; handle using freshly opened DMSO |
| Storage Conditions | Store at –20 °C, protected from light and moisture; prepared solutions stable at –80 °C for up to 6 months |
| Manufacturing Standard | GMP-compliant |
| Applications | Nerve labeling in fluorescence imaging—intact and degenerated nerves |
| Regulatory Status | For laboratory research use only |
Bevonescein selectively binds to extracellular nerve-associated connective tissue, illuminating both intact and degenerated peripheral nerves under fluorescence-guided imaging. It delivers superior contrast for in vivo surgical and ex vivo imaging models, aiding researchers in neurosurgical visualization, nerve regeneration, and surgical monitoring.
Bevonescein is strictly for experimental research use. No human safety or toxicity data is available. Standard laboratory safety measures must be followed.
This product is intended solely for laboratory research. It is not approved for human or veterinary clinical use. Please follow institutional safety protocols when handling.
| 重量 | 1 公斤 |
|---|---|
| 尺寸 | 26 × 23 × 26 厘米 |
Bevonescein (ALM-488) is used as a fluorescent tracer to label intact and degenerated peripheral nerves in real-time imaging.
Bevonescein is provided at high purity and manufactured to GMP standards.
It binds to nerve-associated connective tissue, enabling nerve visualization via fluorescence imaging.
Its molecular weight is approximately 2310.5 Da
Bevonescein is best dissolved in DMSO at high concentration (~100 mg/mL) with ultrasonic assistance
Store as a lyophilized powder at –20 °C, protected from light and moisture. Prepared solutions remain stable at –80 °C for up to six months
No—Bevonescein is strictly for laboratory research use only.
Yes—wholesale and retail options are available, complete with GMP documentation.
Bevonescein excels in neurosurgical fluorescence-guided labeling of degenerated and intact peripheral nerves
It provides superior visibility of degenerated nerves, outperforming traditional myelin-binding dyes in fluorescence-guided imaging
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