Description

Product Description

Biotinoyl Tripeptide-1, also known as Biotinyl-GHK, is a synthetic bioactive peptide conjugated with biotin and the naturally occurring tripeptide sequence glycyl-L-histidyl-L-lysine (GHK). This dual-functional molecule merges the cellular metabolism–boosting effect of biotin with the regenerative and reparative potential of GHK, creating a highly effective cosmetic research compound for studying hair growth stimulation, follicular anchoring, and scalp anti-aging mechanisms.

In cosmetic biochemistry research, Biotinoyl Tripeptide-1 is recognized for its ability to revitalize and reinforce hair follicles, acting at the dermal papilla and extracellular matrix level. By promoting the synthesis of collagen, laminin, and integrins, it enhances the structural integrity of the hair root sheath and improves the anchoring of hair fibers to the scalp. This function makes it particularly valuable for investigations into hair thinning, telogen effluvium, and age-related hair loss processes.

Biotin, a vitamin cofactor known for its role in fatty acid metabolism and keratin production, provides metabolic support to hair matrix cells, while the GHK tripeptide fragment activates repair mechanisms through upregulation of metalloproteinase inhibitors, fibroblast growth, and glycosaminoglycan synthesis. Together, these effects synergistically contribute to stronger, more resilient, and shinier hair in experimental models.

Beyond hair physiology, Biotinoyl Tripeptide-1 has demonstrated neuroprotective and antioxidant properties. It inhibits the production of reactive oxygen species (ROS), reduces carbonylation of amyloid-β (Aβ) peptides, and suppresses Aβ aggregation—factors associated with neurodegenerative research. These properties have led to its exploration as a dual-action peptide capable of supporting both dermal and neural cell vitality.

In cosmetic ingredient studies, Biotinoyl Tripeptide-1 has also been associated with improved microcirculation in the scalp, enhanced nutrient delivery, and anti-inflammatory activity via modulation of cytokines such as IL-6 and TNF-α. It is frequently incorporated into formulations for anti-hair loss serums, strengthening shampoos, and eyelash growth enhancers.

Analytical characterization is typically achieved through HPLC, MS, and NMR, confirming structural identity and ≥99% purity. In vitro assays consistently demonstrate its ability to upregulate collagen IV and laminin-5 synthesis in dermal fibroblasts, while reducing oxidative damage markers under UV or pollutant exposure conditions.

In essence, Biotinoyl Tripeptide-1 serves as a model peptide for exploring the molecular pathways of hair regeneration, skin anti-aging, and oxidative protection—making it indispensable in advanced cosmetic peptide research.

Product Specifications

Mechanism of Action

Biotinoyl Tripeptide-1 functions through a dual biological mechanism—the metabolic activation of keratinocyte and fibroblast energy pathways via biotin, combined with the cell-regenerative signaling of the GHK tripeptide sequence.

At the cellular level, the biotin moiety enhances enzymatic activity related to fatty acid metabolism and keratin synthesis. This supports hair matrix cell proliferation and strengthens hair shaft keratinization, leading to improved fiber structure. Concurrently, the GHK peptide sequence binds to copper ions in the extracellular matrix, activating genes responsible for tissue repair, collagen synthesis, and antioxidant defense.

Through these complementary actions, Biotinoyl Tripeptide-1 promotes anchorage of the hair root by stimulating laminin-5 and collagen IV production in the basement membrane zone. It also upregulates integrins and structural proteins essential for dermal–epidermal cohesion, helping to prevent premature hair shedding in experimental models.

The peptide additionally exhibits ROS-inhibiting activity, reducing oxidative stress induced by UV radiation, pollutants, or DHT-related follicular inflammation. In keratinocyte cultures, it suppresses NF-κB activation and downregulates pro-inflammatory cytokines, creating a favorable microenvironment for scalp rejuvenation and follicle regeneration.

Recent research has identified its ability to modulate mitochondrial function and improve cellular ATP levels in aging dermal cells. These effects contribute to visible improvements in elasticity, tone, and resilience of the scalp and skin in cosmetic model systems.

Collectively, these mechanisms make Biotinoyl Tripeptide-1 an important cosmetic research agent for studying hair strengthening, anti-aging skin care, and oxidative protection strategies.

Side Effects

Biotinoyl Tripeptide-1 is considered non-toxic and well-tolerated in in vitro and ex vivo skin models. No cytotoxic or irritant reactions have been observed at concentrations commonly used in cosmetic formulation studies.

At excessively high doses, some research models report temporary alterations in cell proliferation rates or metabolic overactivation due to biotin’s energetic role, but these effects are reversible upon dilution.

Because it is a research-use-only peptide, it should not be applied directly to human or animal subjects. Proper laboratory handling, protective equipment, and storage conditions should be maintained to preserve peptide stability and avoid contamination.

Keywords

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Shipping Guarantee

All shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.