Description

Bradykinin acetate (CAS No. 6846-03-3) is a biologically active peptide that plays a critical role in vascular physiology, inflammatory processes, and pain signaling. It belongs to the kinin family of peptides and is derived from kininogen through enzymatic cleavage. As a highly effective endothelium-dependent vasodilator, Bradykinin acetate is capable of lowering blood pressure by relaxing vascular smooth muscle, thereby promoting increased blood flow.

In addition to its vasodilatory activity, Bradykinin acetate induces contraction of bronchial and intestinal non-vascular smooth muscle, increases vascular permeability, and participates in pain pathways by stimulating sensory nerve endings. These biological effects make Bradykinin acetate an important research tool in cardiovascular studies, pain mechanism investigations, and inflammatory disorder modeling.

Research applications extend to hypertension, cardiovascular disease, asthma, gastrointestinal motility disorders, and studies on vascular permeability. Its ability to enhance the release of nitric oxide (NO) and prostacyclin underscores its role as a mediator of endothelial function. Furthermore, Bradykinin acetate is of high interest in oncology and immunology studies due to its involvement in vascular leakage and tissue inflammation.

Manufactured in a GMP-compliant facility, this product meets rigorous quality standards with reliable purity for laboratory investigations. Both wholesale and retail supply are supported, making it suitable for academic, pharmaceutical, and biotechnology research institutions.

For laboratory research use only. Not intended for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Bradykinin acetate exerts its biological effects by binding to bradykinin receptors (B1 and B2), which are G-protein-coupled receptors located on endothelial and smooth muscle cells. Activation of the B2 receptor leads to vasodilation through the release of nitric oxide and prostaglandins, which relax smooth muscle and increase vascular permeability.

Research applications include:

• Cardiovascular studies: Regulation of blood pressure and vascular tone.

• Inflammation research: Role in edema, tissue injury, and cytokine release.

• Pain signaling: Contribution to hyperalgesia and neuropathic pain models.

• Respiratory research: Bronchoconstriction studies relevant to asthma.

• Gastrointestinal studies: Smooth muscle contraction and motility regulation.

• Oncology and immunology: Understanding tumor microenvironment vascular leakage.

Its pleiotropic role in multiple systems makes it a versatile and valuable compound in pharmacological and physiological research.

Development & Formulation Notes

Bradykinin acetate is chemically synthesized to ensure high purity and stability. Its acetate salt form enhances solubility and handling in laboratory preparations. For research consistency, formulation is carefully controlled under GMP manufacturing practices.

This product is often utilized in in vitro vascular assays, isolated tissue models, and in vivo studies requiring controlled administration of vasoactive peptides. Researchers are encouraged to prepare aliquots to avoid repeated freeze-thaw cycles.

Side Effects (For Reference in Models)

In laboratory and preclinical models, Bradykinin acetate may cause:

• Hypotension due to vasodilation

• Bronchospasm in airway tissues

• Gastrointestinal smooth muscle contraction

• Increased vascular leakage and edema

• Pain induction via sensory nerve stimulation

These effects are consistent with its natural biological activity and should be considered in experimental design.

Disclaimer

Bradykinin acetate is provided strictly for laboratory research purposes only. It is not intended for human consumption, medical use, or veterinary applications. All handling should follow institutional safety protocols.

Logistics, Packaging & Storage

• Packaging: Supplied in sealed sterile vials (custom sizes available for wholesale and retail orders).

• Shipping: Shipped with temperature-controlled packaging to maintain product integrity during transit.

• Storage: Store at –20°C, protected from moisture and light. Stable for long-term storage under recommended conditions.

• GMP Compliance: Manufactured under Good Manufacturing Practice standards ensuring batch-to-batch consistency.

Keywords

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