描述
Bumetanide is a high-potency loop diuretic that inhibits the Na?/K?/2Cl? cotransporter (NKCC2) in the thick ascending limb of the loop of Henle. It is widely used in preclinical and in vitro studies related to renal physiology, fluid retention, edema, hypertension, and electrolyte homeostasis.
Each ampoule contains 0.5mg of Bumetanide in 2ml of solution. This box includes 6 ampoules, making it suitable for extended dosing in pharmacokinetic, pharmacodynamic, and dose-response research models.
This product is approved by the NMPA (H35020460) and manufactured by Fuzhou Haiwang Fuyao Pharmaceutical Co., Ltd. It is intended strictly for laboratory research purposes only, and not for human or veterinary use.
Product Specifications
Parameter | Details |
---|---|
Product Name | Bumetanide Injection |
Generic Name | Bumetanide |
CAS Number | 28395-03-1 |
Molecular Formula | C17H20N2O5S |
Molecular Weight | 364.42 g/mol |
Dosage Form | Injection |
Strength | 0.5mg per 2ml |
Quantity | 6 ampoules per box |
Approval Number | H35020460 (NMPA, China) |
Product Code | 86904827001755 |
Manufacturer | Fuzhou Haiwang Fuyao Pharmaceutical Co., Ltd. |
Barcode | Not provided |
Intended Use | For laboratory research use only |
Storage Conditions | Store sealed below 25°C; protect from light and heat |
Mechanism of Action & Research Applications
Bumetanide inhibits the Na?/K?/2Cl? transporter (NKCC2) in the loop of Henle, reducing reabsorption of sodium and chloride, resulting in powerful diuretic effects. It is used in:
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Renal physiology research
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Studies of congestive heart failure models
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Neurodevelopmental research (e.g., GABAergic modulation)
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Fluid retention and electrolyte transport studies
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Pharmacokinetic profiling of diuretic drugs
Safety & Handling
Use Restriction: For laboratory use only. Not for human or animal consumption.
Protective Measures: Use gloves, lab coat, and eye protection when handling.
Storage: Keep sealed, store at 2–25°C, away from light.
Disposal: Follow local chemical waste regulations.
Research Use Disclaimer
This product is for laboratory research use only. Not intended for human, diagnostic, therapeutic, or veterinary applications. Use under professional laboratory supervision. Misuse may pose health and legal risks.
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