Description

Product Description

Salmon Calcitonin (CAS 47931-85-1) is a highly characterized peptide widely utilized across biochemical, receptor-binding, molecular signaling, and material–peptide interaction studies. Manufactured through high-precision solid-phase peptide synthesis and purified using advanced chromatographic technologies, this high-purity Salmon Calcitonin peptide offers excellent consistency, structural integrity, and reliability for laboratory workflows that require a well-defined peptide standard. The product is supplied as a sterile freeze-dried powder, ensuring long-term stability and flexibility for diverse research settings, particularly where controlled reconstitution and customizable concentrations are necessary.

This high-purity Salmon Calcitonin peptide is frequently employed in studies exploring calcitonin receptor activation, peptide–GPCR interactions, intracellular signaling cascades, and calcium-regulatory pathways at the molecular and cellular levels. Its well-documented structural profile makes it suitable for mechanistic investigations examining ligand–receptor affinity, receptor desensitization kinetics, secondary messenger modulation, peptide folding dynamics, and comparative assessments among calcitonin analogs. Due to its robust purity specifications, researchers can achieve reproducibility across multiple assays, ensuring consistent outcomes in screening, structural visualization, cross-ligand profiling, and receptor selectivity evaluations.

In biochemical environments, Salmon Calcitonin enables precise probing of peptide conformational behavior, such as disulfide bond stability, secondary structure transitions, and peptide-membrane interactions. These properties support its use in spectroscopy, chromatography validation, bioanalytical method development, and structural comparison across species-derived calcitonin peptides. The stability of the lyophilized format allows researchers to store the material for extended periods without loss of integrity, making it well-suited for laboratories requiring flexible inventory management, bulk ordering, or factory-direct wholesale peptide supply.

In molecular signaling studies, Salmon Calcitonin serves as a reliable tool for dissecting receptor-triggered pathways, including cAMP regulation, G-protein activation, and peptide-mediated feedback loops. Its consistent activity profile allows for controlled experiments examining dose-response relationships, receptor binding curves, and ligand-dependent modulation of downstream regulatory elements under in vitro research conditions. These precise characteristics contribute to its relevance in receptor assay development, structure–function mapping, and multi-omics pipelines where standardized peptide inputs are essential.

From a material-science perspective, Salmon Calcitonin peptide can be integrated into peptide-binding surface studies, biomolecular interface analyses, and controlled-environment peptide distribution experiments. Its defined molecular weight, predictable solubility behavior, and strong chemical stability make it compatible with analytical systems such as HPLC, MS, FTIR, CD spectroscopy, and fluorescence-based detection methods.

Overall, Salmon Calcitonin CAS 47931-85-1 remains a versatile, high-purity peptide that supports a wide spectrum of laboratory research fields. Whether used in signaling assays, receptor-binding evaluations, structural conformational studies, peptide analytic calibration, or comparative peptide modeling, this wholesale-available, factory-manufactured Salmon Calcitonin peptide provides researchers with a dependable foundation for advanced molecular exploration. Its purity, reproducibility, and stability ensure dependable performance, making it an excellent choice for laboratories seeking premium-quality peptide standards for in vitro research applications.

Product Specifications

Solubility and Concentration Recommendations

• Use sterile, peptide-ready solvents.

• Prepare fresh aliquots to avoid freeze–thaw degradation.

• Record concentration and preparation details for reproducibility.

Mechanism of Action

Salmon Calcitonin (CAS 47931-85-1) exhibits a well-characterized molecular mechanism that supports its widespread use in biochemical, receptor-binding, and signaling pathway research. As a peptide ligand with strong affinity for the calcitonin receptor (CTR), Salmon Calcitonin enables controlled investigation of ligand–receptor interactions, receptor activation profiles, secondary messenger regulation, and downstream signaling dynamics under in vitro laboratory conditions. Its structural stability, defined disulfide-bonded conformation, and high receptor-binding selectivity make it valuable for mechanistic modeling, functional mapping, and receptor-specific assay development.

Receptor Engagement and Binding Characteristics

Salmon Calcitonin interacts primarily with the Class B G-protein-coupled calcitonin receptor, enabling researchers to examine ligand-induced receptor conformational shifts, binding kinetics, and structural selectivity. The peptide’s conformation promotes high-affinity association with the receptor’s extracellular domain, making it an excellent model compound for studies involving molecular docking, ligand–receptor structural comparison, competitive inhibition design, and GPCR-ligand specificity research frameworks.

Activation of G-Protein Signaling Pathways

Upon receptor engagement, Salmon Calcitonin promotes activation of Gαs-mediated signaling cascades, resulting in controlled modulation of intracellular second messengers. These processes allow laboratories to study:

• cAMP production dynamics

• G-protein regulatory loops

• Peptide-triggered modulation of downstream effector proteins
  Because the peptide exhibits strong biochemical stability, it enables high reproducibility in comparative signaling experiments and pathway-mapping studies.

Regulation of Intracellular Pathway Nodes

Researchers often utilize Salmon Calcitonin to explore intracellular processes connected to CTR activation, including:

• PKA-associated signaling nodes

• CRE-dependent transcriptional regulatory elements

• Peptide-modulated phosphorylation patterns
  These mechanisms support studies that investigate cross-pathway interactions, signal amplification profiles, and timing-dependent molecular responses under controlled experimental conditions.

Conformational and Structural Mechanistic Insights

The structural arrangement of Salmon Calcitonin—including its characteristic disulfide-linked loop—plays a key role in receptor recognition. This feature makes it suitable for:

• NMR and spectroscopy-based conformation studies

• Peptide-folding analysis

• Structural comparison among calcitonin analogs

• Computational modeling of ligand–GPCR interfaces
  Its predictable folding pattern provides a reference standard for laboratories investigating peptide bio-structures and structure–activity relationships.

Utility in Analytical and Biophysical Mechanism Research

Salmon Calcitonin is frequently used as a benchmark in analytical method development, particularly in:

• HPLC retention modeling

• Mass spectrometry fragmentation pattern mapping

• Fluorescence-based peptide quantification

• Biophysical interaction profiling with membranes or assay substrates
  These mechanistic applications make the peptide a reliable standard for validating assay sensitivity, selectivity, and analytical reproducibility.

Summary of Mechanistic Value in Research

Overall, Salmon Calcitonin’s mechanism of action centers on controlled CTR activation, well-defined GPCR signaling patterns, and reproducible molecular behaviors suitable for in vitro investigations. Its consistent performance, strong receptor affinity, and structural reliability make it ideal for laboratories conducting peptide–receptor interaction research, mechanistic modeling, and biochemical signaling studies. This mechanistic clarity, coupled with high-purity manufacturing, supports its role as a dependable peptide standard for advanced molecular and analytical workflows.

Applications

Salmon Calcitonin supports diverse laboratory uses:

Biochemical & Structural Studies

• Peptide–receptor binding assays

• Intracellular signaling mapping

• Protein–ligand SAR exploration

Analytical Chemistry

• HPLC/LC-MS method development

• Peptide purity benchmark controls

• Calibration standard in quantitation studies

Computational Research

• Protein–peptide docking

• Structural modeling

• Multi-parameter optimization in ligand design

Research Models

Salmon Calcitonin (CAS 47931-85-1) is widely incorporated into a variety of in vitro, biochemical, and analytical research models designed to explore peptide–receptor interactions, intracellular signaling behavior, structural dynamics, and peptide-responsive regulatory networks. Owing to its high purity, consistent activity profile, and well-characterized receptor affinity, it serves as a dependable reference peptide across assay platforms requiring precise molecular inputs and repeatable experimental conditions. The following research model categories illustrate the diverse ways in which Salmon Calcitonin is applied in controlled laboratory environments.

1. Receptor-Binding and GPCR Characterization Models

Salmon Calcitonin is routinely utilized as a model ligand for studying calcitonin receptor (CTR) binding affinity, structural selectivity, and receptor activation mechanics. These models include:

• Ligand–receptor affinity profiling

• Receptor conformational mapping using spectroscopy or computational docking

• Comparative ligand-binding assessments for analog screening
  Such models help researchers understand CTR-binding domains, evaluate binding pocket accessibility, and characterize structure–function relationships.

2. Intracellular Signaling Pathway Models

In vitro signaling systems incorporating Salmon Calcitonin are used to evaluate downstream molecular responses triggered by CTR engagement. These models allow researchers to measure:

• cAMP accumulation patterns

• G-protein regulatory behavior

• Phosphorylation events linked to signaling cascades
  Such controlled frameworks are ideal for examining timing-dependent molecular responses, pathway modulation, and signal amplification under strictly regulated laboratory conditions.

3. Structural Biology and Conformational Dynamics Models

Due to its defined disulfide-bonded conformation and predictable folding behavior, Salmon Calcitonin serves as an exemplary peptide substrate in structural analysis systems, including:

• Circular dichroism (CD) spectroscopy

• NMR structure assessments

• Fourier-transform infrared (FTIR) peptide profiling

• Computational peptide-folding simulations
  These models support investigations into peptide stability, conformational transitions, and comparative folding behavior across peptide families.

4. Biochemical Interaction and Peptide–Material Interface Models

Salmon Calcitonin is used in controlled assays designed to study peptide interactions with membranes, substrates, and engineered materials. Examples include:

• Peptide adsorption studies

• Surface-binding affinity tests

• Membrane–peptide interaction modeling

• Biophysical interaction assays using fluorescence or label-free detection
  These models assist in examining physicochemical behavior, interface stability, and interaction kinetics.

5. Analytical Method Development and Validation Models

Because of its stable structure and reproducible fragmentation patterns, Salmon Calcitonin is frequently selected as a calibration or performance-check peptide in analytical method development. It plays a role in:

• HPLC retention time modeling

• Method robustness testing

• Mass spectrometry fragment verification

• Detection limit and quantification threshold assessments
  Such models are essential for optimizing laboratory workflows that depend on high-purity standards.

6. Peptide Comparison and Analog Screening Models

Salmon Calcitonin is incorporated into frameworks evaluating structural, functional, or biochemical differences among peptide analogs. These include:

• Comparative receptor-binding screens

• Functional performance benchmarking

• Structural substituent evaluation models
  These controlled comparison models facilitate high-throughput screening and peptide library characterization.

  

Experimental Design Considerations

Careful experimental design is essential when using Salmon Calcitonin (CAS 47931-85-1) as a research reagent. The recommendations below focus exclusively on controlled in vitro, biochemical, analytical, and computational workflows to maximize reproducibility, data quality, and safety while avoiding any biological exposure contexts.

Define Clear Objectives and Endpoints

• Specify primary and secondary endpoints before beginning (e.g., receptor affinity, cAMP kinetics, structural stability, MS detection limits).

• Match assay format to the endpoint: ligand–receptor affinity assays for binding constants, real-time biosensor readouts for kinetic parameters, and mass-spectrometry workflows for identity/quantitation.

• Pre-register expected dynamic ranges and limits of detection to guide sample preparation and instrument settings.

Concentration Range, Titration, and Working Solutions

• Perform a pilot titration series to identify the linear response window for your assay. Typical starting working concentrations (for assay optimization) may range from low µg/mL to mg/mL levels depending on method sensitivity—adjust based on instrument response.

• Prepare serial dilutions using peptide-compatible buffers; avoid extreme pH or organic solvent concentrations unless specifically required by the assay.

• Use freshly prepared working solutions and restrict storage time of reconstituted material (see Product Specifications for stability guidance).

Controls, Replication, and Statistical Power

• Include negative controls (buffer only), matrix controls (buffer plus matrix components), and positive/benchmark controls when available. A reference peptide standard (e.g., a validated lot of Salmon Calcitonin) improves cross-run comparability.

• Use technical replicates (≥3) for assay precision and biological-model replicates where appropriate (interpret only within in vitro contexts).

• Estimate sample sizes based on expected effect size and assay variability; perform power calculations during planning to ensure statistical robustness.

Reconstitution, Handling, and Aliquoting Best Practices

• Reconstitute lyophilized Salmon Calcitonin under aseptic, low-disturbance conditions using the recommended solvent. Mix gently; avoid vigorous vortexing that may promote aggregation.

• Aliquot reconstituted solutions into single-use volumes to prevent repeated freeze–thaw and reduce degradation risk. Label aliquots with concentration, solvent, date, and lot number.

• Use low-binding tubes and pipette tips where adsorption may bias concentration measurements.

Buffer Selection and Matrix Considerations

• Choose buffers that maintain peptide structural integrity (neutral pH buffers such as PBS or HEPES are often appropriate). Validate buffer compatibility for assays involving enzymatic steps or detection chemistries.

• Evaluate potential matrix effects (salts, proteins, detergents) that can alter chromatographic retention, ionization efficiency in MS, or receptor interaction profiles.

Analytical Validation and Calibration

• Validate analytic methods (HPLC, LC-MS, spectrophotometry) for linearity, accuracy, precision, and recovery using Salmon Calcitonin reference material and spiked matrices.

• Use internal standards where feasible to correct for extraction or instrument variability. Document retention times, fragmentation patterns, and calibration curves for traceability.

Data Quality, Documentation, and Traceability

• Maintain detailed lab records: lot number, COA reference, reconstitution procedure, exact concentrations, instrument settings, and environmental conditions.

• Implement version-controlled SOPs for preparation, assay execution, and analysis. Archive raw data and processed datasets for reproducibility and review.

Troubleshooting and Common Pitfalls

• Low signal: verify peptide integrity via MS/HPLC and check for adsorption losses (use low-binding consumables).

• High background/noise: evaluate buffer components, solvent purity, and possible carryover; include blank runs between samples.

• Aggregation: optimize solvent composition, reduce concentration, and include gentle mixing; consider filtration where appropriate.

Safety, Compliance, and Ethical Considerations

• Ensure all personnel are trained in safe handling, spill response, and waste disposal specific to peptide materials.

• Confirm that experimental plans adhere to institutional policies and that work remains strictly within research-only, laboratory boundaries. Keep COA and safety documentation accessible.

  

Laboratory Safety & Handling Guidelines

Handling Salmon Calcitonin (CAS 47931-85-1) requires adherence to standard laboratory chemical-safety practices. Personnel should utilize appropriate PPE at all times, including gloves, lab coats, and protective eyewear. Avoid creating dust or aerosol when opening vials; handle the lyophilized powder in a controlled workspace such as a laminar-flow hood to minimize contamination or particulate dispersion.

Because peptides can be sensitive to moisture, ensure minimal exposure to humid conditions. Always keep the material in sealed containers and store at recommended temperatures. When preparing solutions, use certified laboratory-grade solvents and clearly label reconstituted aliquots with concentration and preparation dates. Limit exposure to non-ideal temperatures and prevent unnecessary agitation that may affect peptide stability.

In the event of accidental spills, dampen the area to prevent airborne particles and wipe with absorbent materials. Dispose of waste following chemical disposal regulations. Avoid vacuuming or sweeping dry powder. After handling, wash hands thoroughly, even if gloves were worn.

All equipment contacting the peptide should be cleaned using approved laboratory decontamination procedures. Use dedicated tools when possible to avoid cross-contamination.

This material is intended exclusively for controlled laboratory research, such as biochemical, analytical, or structural testing. It must not be used in any biological exposure setting. All experimental setups should incorporate safety controls consistent with institutional requirements.

Integration with Multi-Omic & Computational Studies

• Proteomic quantification workflows

• Structural informatics mapping

• Molecular network modeling

• Cross-omics pathway correlation

• Peptide structural prediction systems

Keywords

Salmon Calcitonin, CAS 47931-85-1, high-purity peptide powder, freeze-dried peptide, factory-manufactured peptide, wholesale peptide, analytical peptide standard

Shipping Guarantee

Our Salmon Calcitonin is delivered using temperature-controlled logistics to preserve peptide integrity during transit. Packaging is tamper-proof and designed to maintain a dry, stable environment for the lyophilized powder. Global shipping coverage ensures that research laboratories worldwide can receive the material reliably and on schedule. Bulk packaging options are available for high-volume research applications, allowing efficient distribution and storage.

Trade Assurance

We offer factory-direct sourcing for Salmon Calcitonin, guaranteeing consistent quality and authentic high-purity peptide. Every batch comes with verified purity documents, including COA and HPLC/MS reports, to ensure transparency and reproducibility. Our stable supply chain supports continuous laboratory research projects, and OEM customization is available for institutional or commercial requirements.

Payment Support

Flexible payment options are provided to accommodate global research institutions and commercial buyers. Accepted methods include bank transfer, PayPal, and major credit cards, ensuring secure and convenient transactions. Corporate procurement channels are also supported to facilitate bulk or repeated orders, simplifying financial processing for large-scale research facilities.

Disclaimer

Salmon Calcitonin is intended exclusively for laboratory research purposes. It is not for human or veterinary use, and no clinical or therapeutic claims are implied. Researchers must handle this material in accordance with institutional safety protocols and regulatory guidelines, ensuring it is only applied in controlled in vitro or analytical workflows.

References

• PubChem – Salmon Calcitonin
  https://pubchem.ncbi.nlm.nih.gov/compound/Salmon-Calcitonin
  Comprehensive chemical information including molecular formula, molecular weight, and physicochemical properties.

• NCBI Protein Database – Salmon Calcitonin
  https://www.ncbi.nlm.nih.gov/protein/
  Protein sequence and structural data for research-grade peptide studies and receptor interaction modeling.

• RCSB Protein Data Bank (PDB) – Calcitonin-Receptor Complexes
  https://www.rcsb.org/
  Structural insights for ligand–receptor docking, molecular dynamics, and GPCR modeling studies.

• ScienceDirect – Analytical Methods for Peptides
  https://www.sciencedirect.com/
  Articles detailing HPLC, LC-MS, and spectroscopy approaches applicable to Salmon Calcitonin research.

• Nature Protocols – Peptide Structural Analysis
  https://www.nature.com/nprot/
  Protocols for NMR, CD spectroscopy, and peptide conformational studies.

• Analytical Chemistry – Peptide Calibration and Standardization
  https://pubs.acs.org/journal/ancham
  Studies on analytical performance validation using high-purity peptide standards.

• Journal of Peptide Science – Structural and Functional Studies
  https://onlinelibrary.wiley.com/journal/10991308
  Research articles focused on peptide–receptor interaction assays and structural-functional characterization.

• Frontiers in Molecular Biosciences – GPCR-Peptide Interactions
  https://www.frontiersin.org/journals/molecular-biosciences
  Mechanistic studies and computational modeling of peptide-mediated receptor signaling.

• Journal of Chromatography B – Peptide Analytical Method Development
  https://www.sciencedirect.com/journal/journal-of-chromatography-b
  Reference for HPLC and LC-MS assay design using high-purity peptide materials.

• Protein & Peptide Letters – Calcitonin Analog Research
  https://www.eurekaselect.com/journal/28