描述
Calcium Folinate Product Specifications
| Attribute |
Details |
| Product Name |
Calcium Folinate Injection (Leucovorin) |
| Strength |
100?mg per vial |
| Quantity |
5 vials per box |
| Dosage Form |
Sterile powder for injection |
| Approval No. (NMPA) |
H20053382 |
| Product Code |
86903458000403 |
| Manufacturer |
Guoyao Yixin Pharmaceutical Co., Ltd |
| CAS Number |
56?88?4 (folinic acid) |
| Molecular Formula |
C??H??CaN?O?·5H?O; ~601.6?g/mol |
| Intended Use |
Laboratory research only — not for clinical or veterinary use |
Mechanism of Action
Calcium Folinate is an active tetrahydrofolate analogue that bypasses dihydrofolate reductase inhibition, replenishing nucleic?acid precursor pools to rescue normal cells after antifolate exposure. It also enhances fluoropyrimidine cytotoxicity by stabilizing thymidylate synthase complexes.
Research & Pharmacology Context
-
Folate antagonist rescue: Standard antidote after high-dose methotrexate or pyrimidine analog therapy in preclinical models.
dailymed.nlm.nih.gov+9anmfonline.org+9pdf.hres.ca+9
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Chemotherapy enhancement: Used in conjunction with 5?fluorouracil in colorectal cancer models to improve efficacy.
-
Clinical & pharmacokinetic data: Widely used injectable form; over 90% renal excretion, clinical dosing from adult chemotherapy protocols.
? Research Applications
-
Antidote profiling in high-dose methotrexate toxicity models
-
Synergy studies with fluoropyrimidines in colorectal cancer cell lines or xenografts
-
Folate metabolism and nucleotide synthesis pathway research
-
Pharmacokinetic/pharmacodynamic modeling in preclinical studies
?? Research?Use Only Disclaimer
This product is provided strictly for laboratory research and development use only. Not intended for clinical, diagnostic, therapeutic, or veterinary applications.
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