Carperitide (Atrial Natriuretic Peptide, ANP 1-28) | GMP Supplier & Wholesale Research Grade Peptide

描述

Carperitide (Atrial Natriuretic Peptide, ANP 1-28, human/porcine) is a naturally occurring 28-amino acid peptide hormone primarily secreted by the atrial myocardium in response to increased cardiac pressure and mechanical stretch. It plays a critical role in regulating cardiovascular homeostasis through natriuretic, diuretic, and vasodilatory effects. In scientific research, Carperitide has been widely investigated for its ability to reduce cardiac stress, modulate renal sodium excretion, and influence vascular tone.

One of the defining characteristics of Carperitide is its ability to inhibit endothelin-1 secretion in a dose-dependent manner, which positions it as a valuable peptide for cardiovascular studies involving vasoconstriction and vascular remodeling. Researchers have employed Carperitide in models of heart failure, hypertension, and kidney function regulation, as well as in mechanistic studies of atrial natriuretic peptide receptors (NPR-A and NPR-C).

Carperitide is available in both its free peptide form and salt form (Carperitide acetate). While both exhibit comparable biological activity at equivalent molar concentrations, the acetate form offers enhanced water solubility and improved stability, making it preferable for many laboratory applications.

As a GMP-compliant research product,  is manufactured to ensure high purity, reproducibility, and safety for laboratory investigations. This makes it an essential tool for researchers in cardiovascular, renal, and endocrine research fields. Not intended for human or veterinary use. Laboratory research only.

Product Specifications

Mechanism of Action & Research Applications

Carperitide functions as a natural ligand for natriuretic peptide receptors, primarily NPR-A. Upon receptor activation, Carperitide stimulates guanylyl cyclase activity, increasing intracellular cyclic GMP (cGMP) levels, which trigger downstream signaling pathways. This results in vasodilation, natriuresis (sodium excretion), diuresis, and suppression of renin-angiotensin-aldosterone system (RAAS) activity.

In cardiovascular research, Carperitide has been extensively studied for its cardioprotective effects, particularly in models of acute heart failure and myocardial ischemia. Its ability to reduce preload and afterload by promoting vasodilation makes it valuable in understanding mechanisms of cardiac unloading.

In renal physiology, Carperitide has been used to investigate glomerular filtration rate (GFR) regulation, sodium and water balance, and the interplay between natriuretic peptides and renal sympathetic activity. Additionally, its inhibitory action on endothelin-1 secretion provides researchers with insights into vascular remodeling and the balance between vasodilators and vasoconstrictors.

Carperitide acetate, with its enhanced solubility and stability, is particularly useful in long-duration experiments where peptide stability is crucial. The peptide continues to serve as a cornerstone in experimental models of cardiovascular and renal diseases, offering valuable translational insights.

Side Effects (For Reference in Models)

In laboratory models, Carperitide has been associated with certain dose-dependent physiological responses, including:

• Hypotension due to vasodilation

• Increased urine output (diuresis) and sodium excretion (natriuresis)

• Reduced plasma renin activity

• Possible reflex tachycardia in high-dose models

These effects are consistent with its natural role as a natriuretic peptide. They should be considered when designing experimental protocols. All listed effects are for scientific reference in research models only.

Disclaimer

This product is intended for laboratory research use only. It is not intended for human consumption, medical, veterinary, or household use. Researchers must handle according to GMP laboratory safety standards.

Keywords

CAS 89213-87-6, Atrial Natriuretic Peptide ANP 1-28, GMP Carperitide supplier, cardiovascular peptide research, natriuretic peptide studies, wholesale research peptides