Description

Product Description

CBLB 612 is a synthetic compound identified as a potent anti-radiation and stem cell mobilizing agent. It has been shown to stimulate hematopoietic stem cells (HSCs) under moderate activation, facilitating their migration from bone marrow into peripheral blood circulation. This mobilization effect makes it a valuable research compound for studying hematopoiesis, radiation-induced damage, and tissue recovery.

Preclinical studies indicate that CBLB 612 promotes the survival and functional recovery of hematopoietic progenitor cells following radiation exposure. It acts as a protective modulator by inducing cytokine expression and enhancing bone marrow regeneration. Its dual capacity to protect against radiation and facilitate hematopoietic recovery positions CBLB 612 as a promising compound in regenerative medicine and oncology.

Furthermore, CBLB 612 has been explored as an adjunctive agent in cancer therapy. Radiation therapy often causes myelosuppression and immune dysfunction — CBLB 612 counteracts these effects by supporting bone marrow homeostasis and accelerating hematopoietic reconstitution. Its mechanism of inducing HSC mobilization without excessive stimulation provides an advantage for maintaining hematopoietic balance during cytotoxic treatment.

In experimental models, CBLB 612 demonstrates:

• Protection against radiation-induced apoptosis in bone marrow cells

• Enhanced mobilization of functional HSCs into peripheral blood

• Support for immune system recovery post-irradiation

• Synergistic effects with growth factors such as G-CSF and SCF

These properties make CBLB 612 a highly relevant research compound for fields involving stem cell biology, radioprotection, regenerative medicine, and hematologic recovery.

Product Specifications

• Product Name: CBLB 612

• CAS Number: 1039381-80-0

• Purity: ≥99%

• Molecular Formula: Not specified

• Molecular Weight: Not specified

• Appearance: Solid powder

• Solubility: Soluble in DMSO or aqueous buffers

• Storage: Store at -20°C, protected from light and moisture

• Shelf Life: ≥2 years when stored properly

• Formulation: Research-grade compound

• Category: Anti-radiation and hematopoietic stem cell mobilizing agent

Synonyms

• CBLB-612 compound

• Radioprotective stem cell mobilizer

• Hematopoietic recovery enhancer

Mechanism of Action

CBLB 612 functions primarily as a signaling modulator within hematopoietic tissues. It activates intracellular pathways that upregulate protective and regenerative responses in bone marrow stem cells. By modulating cytokine signaling networks, such as IL-6, SCF, and G-CSF pathways, it supports both stem cell proliferation and mobilization.

Upon exposure to radiation, hematopoietic cells suffer oxidative and DNA damage leading to apoptosis and depletion. CBLB 612 counteracts this effect by:

1. Reducing oxidative stress via antioxidant gene activation.

2. Enhancing bone marrow stromal support through increased cytokine secretion.

3. Mobilizing stem cells from bone marrow to peripheral blood for faster hematopoietic restoration.

The compound also exhibits anti-apoptotic and immune-modulatory effects, creating a favorable environment for hematopoietic regeneration. This multifaceted mechanism suggests that CBLB 612 could serve as a lead compound in developing radioprotective therapeutics.

Side Effects

In experimental research, CBLB 612 has demonstrated low toxicity and high selectivity toward hematopoietic tissues. Potential effects observed in preclinical studies include:

• Transient increases in cytokine levels

• Mild physiological stress response

• Temporary immune activation

No severe side effects have been reported at research-level dosages. Long-term or clinical effects remain under investigation and should be evaluated with appropriate controls.

Disclaimer

All products,  are intended for laboratory research use only. They are not for human or veterinary use, and not intended for drug, diagnostic, or therapeutic applications.

Keywords

 CAS 1039381-80-0, anti-radiation compound, hematopoietic stem cell mobilization, HSC proliferation, radioprotection agent, cancer research chemical, regenerative medicine compound, research use only

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Trade Assurance

Our products are backed by a 100% quality and authenticity guarantee. Each batch of CBLB 612 undergoes rigorous purity testing (≥99%) and is accompanied by analytical documentation to ensure research-grade reliability.