Description

Product Description 

Ceruletide Peptides Powder is a research-grade, high-purity synthetic peptide widely utilized to investigate gastrointestinal and neuropharmacological pathways. Produced under GMP-compliant conditions, it guarantees excellent stability, sterility, and reproducibility, ensuring reliable outcomes for mechanistic and functional research. Its lyophilized format enables long-term storage stability and convenient reconstitution for laboratory applications.

Ceruletide mimics the activity of naturally occurring cholecystokinin-like peptides, facilitating studies on digestive enzyme secretion, smooth muscle contraction, and gastrointestinal motility. It is also applied in neurobiological research to study receptor-mediated signaling and neurotransmitter regulation. Its high purity and validated bioactivity allow precise experimental control and reproducible results in both in vitro and in vivo studies.

The peptide is fully customizable, supporting modifications to sequence, concentration, excipients, and packaging. Bulk supply and low-cost wholesale availability make it suitable for high-throughput experiments, multi-lab collaborations, and large-scale animal studies. Each batch undergoes rigorous HPLC, mass spectrometry, and amino acid analysis, guaranteeing ≥98% purity and consistent biological activity.

In vitro, Ceruletide is applied to primary gastrointestinal cells, neuronal cultures, organoids, and immortalized cell lines to explore receptor activation, signaling pathways, and secretion mechanisms. In vivo, it supports rodent studies assessing enzyme secretion, gastrointestinal motility, smooth muscle contraction, and neuropharmacological responses.

Ceruletide Peptides Powder is also suitable for high-throughput screening, combinatorial studies, and mechanistic modeling. Its compatibility with multi-omic approaches allows researchers to integrate transcriptomic, proteomic, metabolomic, and lipidomic data to analyze peptide-mediated effects at the system level.

Overall, Ceruletide Peptides Powder provides a versatile, reliable, and high-quality research tool, combining reproducibility, flexibility, and GMP-grade quality. Its high purity, factory manufacturing, and bulk availability make it ideal for laboratories seeking consistent, customizable peptide reagents for advanced research in pharmacology, gastrointestinal physiology, and neuroscience.

Product Specifications

Notes:

• Purity & Validation: Each batch undergoes HPLC, MS, and amino acid analysis for ≥98% purity.

• Bulk & OEM Supply: Bulk options and customizable packaging are available for high-throughput research.

• Handling & Solubility: Readily soluble in aqueous buffers; low-binding tubes recommended.

• Sterility & Endotoxin Control: Suitable for sensitive in vitro and in vivo applications.

• Storage Recommendations: Store at 2–8 °C, protected from light and moisture; aliquot to prevent repeated temperature fluctuations.

Mechanism of Action 

Ceruletide Peptides Powder acts as a potent agonist of cholecystokinin (CCK) receptors, primarily CCK-A and CCK-B subtypes, which are widely expressed in the gastrointestinal tract, pancreas, and central nervous system. By binding to these receptors, Ceruletide triggers intracellular signaling cascades involving G-protein activation, phospholipase C stimulation, inositol triphosphate (IP3) production, and subsequent calcium mobilization, leading to enzyme secretion, smooth muscle contraction, and neurotransmitter release. Its high purity ensures specific receptor engagement and minimal off-target effects, providing reproducible and accurate experimental results.

In gastrointestinal studies, Ceruletide promotes pancreatic enzyme secretion, gallbladder contraction, gastric acid release, and intestinal motility, mimicking physiological cholecystokinin activity. These effects are particularly valuable for investigating digestive physiology, enzyme regulation, and smooth muscle pharmacology.

At the cellular level, Ceruletide modulates signal transduction pathways including calcium-dependent kinase activation, intracellular phosphorylation events, and transcriptional regulation of digestive enzymes. In neuronal models, it influences neurotransmitter release, receptor-mediated excitability, and neuromodulation, providing insight into the neuro-gastrointestinal axis.

In vivo, Ceruletide administration induces acute, measurable physiological responses in rodent models, such as enzyme release, gastrointestinal motility, and changes in pancreatic secretory activity. Its stable, lyophilized formulation allows precise dosing, reproducible pharmacokinetics, and consistent biological responses across multiple studies.

Ceruletide’s predictable pharmacological profile also enables integration with multi-omic and computational analyses, including transcriptomic, proteomic, and metabolomic mapping, to correlate receptor activation with systemic physiological effects. Computational modeling can further elucidate dose-response relationships, signaling network dynamics, and receptor-ligand interactions, enhancing mechanistic understanding.

Overall, Ceruletide Peptides Powder offers high receptor specificity, reproducible bioactivity, and versatile application across in vitro and in vivo studies. Its GMP-grade quality, customizable formulation, and validated stability make it a reliable tool for research in digestive physiology, pharmacology, neurobiology, and receptor-mediated signaling pathways.

Applications 

Ceruletide Peptides Powder is widely utilized in gastrointestinal, neuropharmacological, and enzymatic research due to its high purity, reproducible activity, and receptor specificity. In gastrointestinal physiology, it serves as a research tool to study pancreatic enzyme secretion, gallbladder contraction, gastric acid release, and intestinal motility. Researchers can investigate the mechanisms underlying digestive processes, smooth muscle activity, and receptor-mediated signaling in both in vitro and in vivo models.

In neuropharmacology, Ceruletide enables the exploration of cholecystokinin receptor signaling in the central nervous system, including regulation of neurotransmitter release, neuronal excitability, and neuro-gastrointestinal communication. It is applicable to neuronal cultures, brain slice preparations, and rodent studies evaluating CNS-mediated modulation of digestive and metabolic pathways.

Ceruletide is also suitable for enzyme kinetics and secretion studies, providing insights into intracellular signaling, calcium mobilization, and kinase activation. Its high purity ensures minimal off-target effects, allowing precise determination of receptor-mediated responses and functional outcomes.

The peptide is compatible with high-throughput screening, combinatorial studies, and mechanistic modeling, facilitating the investigation of interactions between Ceruletide, other peptides, or pharmacological agents. Researchers can integrate multi-omic datasets, including transcriptomics, proteomics, metabolomics, and lipidomics, to assess system-level effects and generate predictive models of receptor-mediated physiology.

In addition, Ceruletide Peptides Powder supports in vivo pharmacological studies, including acute or chronic administration in rodent models. Researchers can monitor enzyme secretion, motility, pancreatic and gallbladder responses, and behavioral endpoints, with reproducible and predictable bioactivity.

Overall, Ceruletide Peptides Powder is a versatile and reliable tool for laboratories studying gastrointestinal physiology, neuropharmacology, receptor signaling, and enzymatic regulation. Its high purity, GMP-grade quality, and customizable packaging options make it ideal for researchers requiring reproducible, high-quality peptide reagents for advanced experimental studies.

Research Models 

Ceruletide Peptides Powder is compatible with a broad range of in vitro and in vivo research models, providing flexibility for studies in gastrointestinal physiology, neuropharmacology, and enzyme regulation. In vitro, it can be applied to primary pancreatic acinar cells, intestinal smooth muscle cells, neuronal cultures, organoids, and immortalized cell lines to study receptor-mediated signaling, enzyme secretion, and intracellular calcium dynamics. Its high purity ensures minimal off-target effects and reproducible results across multiple experimental replicates.

For gastrointestinal research, Ceruletide facilitates studies of enzyme secretion, gallbladder contraction, and gastric motility in cellular and tissue preparations. Researchers can quantify peptide-induced responses, investigate signaling pathways, and evaluate receptor specificity under controlled conditions. Dose-response studies allow precise determination of effective concentrations for both acute and chronic experiments.

In neuropharmacology research, Ceruletide can be used in neuronal cultures, brain slices, or rodent CNS models to explore cholecystokinin receptor activation, neurotransmitter release, and neuro-gastrointestinal interactions. The peptide’s stable bioactivity ensures consistent results in studies of receptor signaling, synaptic modulation, and neuronal excitability.

In vivo models, including mice and rats, enable evaluation of Ceruletide’s effects on pancreatic enzyme release, smooth muscle contraction, gastrointestinal motility, and central nervous system-mediated responses. Its GMP-grade, high-purity formulation ensures reproducible pharmacokinetics and pharmacodynamics, supporting both acute and chronic dosing studies while maintaining experimental integrity.

Ceruletide Peptides Powder is also suitable for multi-omic and computational integration, allowing researchers to combine transcriptomic, proteomic, metabolomic, and lipidomic data to map peptide-mediated signaling networks. Computational modeling can further aid in predicting system-level responses, receptor dynamics, and functional outcomes.

Overall, Ceruletide Peptides Powder provides a robust, reproducible, and versatile platform for both cellular and whole-animal research, supporting comprehensive investigations of receptor biology, digestive physiology, neuropharmacology, and enzymatic regulation. Its high purity, GMP-grade quality, and customizable options make it suitable for advanced integrative studies.

Experimental Design Considerations 

When designing experiments with Ceruletide Peptides Powder, several key factors should be considered to ensure reliable, reproducible results. Dose selection is critical, as Ceruletide elicits dose-dependent effects on receptor activation, enzyme secretion, smooth muscle contraction, and neuronal signaling. In vitro studies should begin with range-finding assays to identify the minimal effective concentration, while in vivo dosing should be tailored according to species, body weight, and physiological endpoints.

The timing and frequency of administration can significantly influence experimental outcomes. Acute versus chronic dosing may yield distinct physiological responses, and repeated administration may result in receptor desensitization or compensatory signaling changes. Researchers should carefully define treatment schedules, sampling points, and endpoints for both cellular and animal models.

Handling and storage are crucial for maintaining bioactivity and sterility. Lyophilized Ceruletide should be stored at 2–8 °C, protected from light and moisture. Reconstitution should occur immediately before use, and aliquoting is recommended to minimize repeated freeze-thaw cycles. Using low-binding tubes and tips ensures accurate peptide dosing and prevents loss due to adsorption.

For combinatorial studies, the sequence and timing of co-treatments should be controlled to isolate Ceruletide-specific effects. Appropriate negative and positive controls, including vehicle-treated samples and alternative peptide sequences, should be included to validate experimental outcomes.

Integration with multi-omic and computational studies requires careful planning regarding sample collection, time points, and replicates to ensure statistical power and data interpretability. Detailed documentation of batch numbers, COA, MSDS, and experimental conditions is essential to maintain reproducibility and compliance.

By following these experimental design considerations, researchers can maximize the utility of Ceruletide Peptides Powder, obtain biologically meaningful results, and ensure experimental integrity across in vitro and in vivo studies investigating cholecystokinin receptor biology, digestive physiology, and neuropharmacology.

Laboratory Safety & Handling Guidelines 

Ceruletide Peptides Powder is intended exclusively for laboratory research use and must be handled in accordance with institutional biosafety protocols. Researchers should always wear personal protective equipment (PPE), including lab coats, gloves, and eye protection, to prevent accidental exposure to skin, eyes, or mucous membranes. In the event of contact, rinse immediately with water and seek guidance from safety personnel if necessary.

All handling should occur in a designated workspace or biosafety cabinet to minimize contamination risk. The lyophilized peptide should be stored at 2–8 °C, protected from light and moisture, and reconstituted immediately before use. Use low-binding tubes and pipette tips to prevent adsorption and maintain accurate dosing. Avoid repeated freeze-thaw cycles by aliquoting reconstituted peptide for experimental use.

During experiments, care should be taken to prevent aerosol generation and accidental spills. All waste, including unused peptide, contaminated consumables, and buffer solutions, must be disposed of according to institutional biosafety and chemical waste regulations. Laboratory surfaces, equipment, and tools should be disinfected with 70% ethanol or other validated cleaning agents after handling.

Ceruletide Peptides Powder is not intended for human or veterinary applications, clinical use, or ingestion. Researchers must adhere strictly to SOPs for storage, handling, and administration, ensuring research integrity and personal safety.

Maintaining detailed records, including COA, MSDS, batch QC reports, and experimental documentation, supports compliance, traceability, and reproducibility. By following these safety guidelines, researchers can use Ceruletide Peptides Powder safely, preserve its bioactivity and sterility, and achieve reliable, reproducible outcomes in both in vitro and in vivo studies.

Integration with Multi-Omic & Computational Studies 

Ceruletide Peptides Powder is highly compatible with multi-omic research approaches, including transcriptomics, proteomics, metabolomics, and lipidomics, enabling comprehensive analyses of cholecystokinin receptor-mediated signaling and gastrointestinal or neuropharmacological pathways. Its high purity and validated bioactivity provide consistent results for both cellular and animal models, allowing researchers to link molecular changes with functional outcomes.

In transcriptomic studies, Ceruletide facilitates the investigation of gene expression changes associated with enzyme secretion, smooth muscle contraction, and receptor signaling pathways. Proteomic analyses enable detection of post-translational modifications, signaling cascades, and protein-protein interactions downstream of CCK receptor activation. Metabolomic and lipidomic studies provide insight into energy metabolism, digestive enzyme regulation, and intracellular signaling networks, allowing a system-level understanding of peptide effects.

Integration with computational models enables predictive analysis of Ceruletide-mediated receptor activity, dose-response relationships, and signaling network dynamics. High-throughput experiments combining Ceruletide with other peptides or small molecules allow the identification of synergistic or antagonistic effects, enhancing mechanistic insights.

Ceruletide Peptides Powder’s stable lyophilized format and GMP-grade quality ensure reproducibility across multi-omic workflows and large experimental cohorts. Researchers can design experiments to correlate molecular, physiological, and functional data, providing a holistic view of peptide-mediated mechanisms.

Overall, Ceruletide Peptides Powder provides a robust, versatile, and reproducible platform for combining experimental biology with computational and integrative analyses. Its high purity, customizable options, and validated stability make it an ideal tool for advanced research in digestive physiology, neuropharmacology, and receptor signaling, supporting mechanistic and system-level investigations.

Side Effects (Research Observations Only)

In laboratory research settings, Ceruletide Peptides Powder exhibits predictable, dose-dependent effects limited to experimental models. In vitro studies may demonstrate enhanced enzyme secretion, intracellular calcium mobilization, smooth muscle contraction, and activation of receptor-mediated signaling pathways, which are considered normal and reversible responses under controlled experimental conditions.

In vivo studies in rodent models may reveal transient physiological changes such as increased pancreatic enzyme release, gallbladder contraction, gastric motility, or mild behavioral alterations. These effects are generally short-lived and reversible, reflecting the peptide’s intended mechanism of action.

No systemic toxicity or irreversible cellular damage has been reported when Ceruletide is used within recommended research dosing ranges. Researchers should carefully monitor cells or animals for any unexpected responses and adhere to established experimental protocols.

All observed effects are strictly research observations and should not be extrapolated to human or veterinary use. Ceruletide Peptides Powder is intended exclusively as a research reagent, and its safety or efficacy for clinical or therapeutic applications has not been evaluated. Proper handling, storage, and dosing practices are essential to ensure reproducible and biologically meaningful experimental outcomes.

Keywords

Ceruletide, Ceruletide Peptides Powder, high-purity peptide, GMP-grade peptide, research peptide, CCK receptor agonist, gastrointestinal research, neuropharmacology research, enzyme secretion studies, in vitro studies, in vivo studies, receptor signaling, multi-omic integration, pharmacology research, wholesale peptide, OEM/custom peptide, digestive physiology research.

Shipping Guarantee

All shipments of Ceruletide Peptides Powder utilize temperature-controlled packaging at 2–8 °C to maintain peptide stability and sterility. Moisture-protected, tamper-evident containers ensure product integrity during transport. Each order includes tracking, batch documentation, and quality verification, ensuring reproducible delivery for laboratory research applications.

Trade Assurance

Factory-direct supply guarantees high-purity GMP-grade Ceruletide, with customizable bulk quantities and OEM options. Each batch includes COA, MSDS, QC reports, and batch traceability, supporting institutional compliance and reproducibility. Guaranteed quality and on-time delivery enable reliable planning for both in vitro and in vivo research projects.

Payment Support

We accept bank transfer, corporate credit, and secure online payment methods suitable for international research institutions. Flexible arrangements are available for bulk, multi-unit, or OEM orders, with full transaction documentation for traceability and compliance.

Disclaimer

Ceruletide Peptides Powder is for laboratory research use only. It is not intended for human or veterinary applications, clinical use, or consumption. Users must adhere strictly to institutional biosafety and regulatory protocols. This product is designed solely as a research reagent and has not been evaluated for therapeutic or clinical purposes.

References

1. Cholecystokinin Receptor Signaling and Peptide Agonists
   A comprehensive review of cholecystokinin receptor biology, peptide agonists, and their applications in gastrointestinal and neuropharmacological research.
   NCBI Bookshelf

2. PubChem: Ceruletide Chemical and Bioactivity Information
   Detailed chemical properties, bioactivity, and analytical data for Ceruletide.
   PubChem

3. UniProt: Cholecystokinin Receptors
   Protein sequences, receptor pathways, and functional annotations relevant to Ceruletide research.
   UniProt

4. Structural Studies of Ceruletide and CCK Receptor Interactions
   Crystallography, receptor-ligand interaction analysis, and mechanistic insights.
   RCSB Protein Data Bank

5. High-Purity Peptides for Laboratory Research
   GMP-grade peptide synthesis, quality control, and applications in physiological and pharmacological studies.
   ScienceDirect – Peptides