Description

Product Description 

Colulintide Peptides Powder is a research-grade, high-purity synthetic peptide developed for molecular, cellular, and in vivo experimental applications. Produced under GMP-compliant conditions, the powder guarantees excellent stability, sterility, and reproducibility, providing reliable results for mechanistic and functional studies. Its lyophilized form ensures long-term storage stability and convenient reconstitution in suitable buffers for experimental use.

Designed for flexibility, Colulintide Peptides Powder supports customization of sequence, concentration, excipients, and packaging, allowing researchers to tailor the peptide for specific experimental needs. Bulk supply and low-cost wholesale availability facilitate large-scale studies, high-throughput screening, and multi-laboratory research collaborations. Each batch undergoes rigorous HPLC, mass spectrometry, and amino acid composition validation, ensuring ≥98% purity and consistent bioactivity.

In in vitro applications, Colulintide can be employed to study receptor-ligand interactions, signaling pathways, enzymatic modulation, and functional cellular responses. It is compatible with primary cells, immortalized cell lines, organoids, and tissue slices, allowing comprehensive investigation of metabolic, neuropharmacological, or molecular mechanisms. High purity reduces off-target effects, ensuring precise experimental control and reproducibility across replicates.

For in vivo studies, Colulintide Peptides Powder supports administration in rodent models to examine physiological responses, receptor activation, and peptide-mediated signaling. Its stable formulation allows accurate dosing, predictable pharmacodynamic outcomes, and integration with multi-omic and computational research approaches. Researchers can combine transcriptomics, proteomics, metabolomics, and lipidomics to map system-level responses to peptide treatment.

Colulintide is also suitable for high-throughput screening, combinatorial studies, and mechanistic modeling. Its low endotoxin content (<0.1 EU/µg) and water solubility enable direct use in laboratory experiments. Researchers can conduct acute, dose-response, or chronic studies while maintaining peptide integrity and sterility.

Overall, Colulintide Peptides Powder is a versatile, high-quality research tool, offering reproducible, customizable peptide reagents for molecular, cellular, and in vivo studies. Its combination of high purity, factory manufacturing, bulk availability, and low-cost wholesale supply makes it an ideal choice for laboratories pursuing cutting-edge peptide research.

Product Specifications

Notes:

• Purity & Validation: Each batch is verified by HPLC, MS, and amino acid analysis to ensure ≥98% purity and activity.

• Bulk & OEM Supply: Available in bulk for large-scale research and with customization options for experimental flexibility.

• Handling & Solubility: Readily soluble; use low-binding tubes to minimize adsorption.

• Sterility & Endotoxin Control: Safe for in vitro and in vivo studies; supports sensitive experimental designs.

• Storage Recommendations: Store at 2–8 °C, protected from light and moisture. Aliquot to avoid repeated temperature fluctuations.

Mechanism of Action

Colulintide Peptides Powder exerts its biological activity through sequence-specific interactions with target receptors, enzymes, or intracellular signaling proteins, depending on the experimental context and peptide design. In molecular and cellular systems, Colulintide can mimic, enhance, or inhibit the effects of endogenous ligands, leading to modulation of receptor-mediated signaling pathways, second messenger systems, and downstream transcriptional programs. Its high-purity formulation ensures precise receptor engagement, minimizing off-target effects and supporting reproducible experimental outcomes.

In metabolic studies, Colulintide has been shown in preclinical research to influence cellular energy homeostasis, hormone secretion, and enzymatic activity. By interacting with specific receptors or signaling molecules, it can modulate intracellular cascades such as kinase activation, phosphorylation events, and gene expression regulation, allowing researchers to dissect mechanistic pathways in vitro and in vivo.

In pharmacological models, Colulintide may act as an agonist, partial agonist, or antagonist depending on the target receptor, providing valuable insights into dose-response relationships, receptor specificity, and signaling kinetics. Its stable, lyophilized format allows consistent bioactivity after reconstitution, enabling accurate quantitative studies across multiple experiments.

Neuroscience and cell biology applications benefit from Colulintide’s ability to modulate synaptic transmission, neuronal excitability, and intracellular signaling networks. By carefully controlling dosage and timing, researchers can explore peptide-mediated regulation of neuronal function, receptor plasticity, and network activity, supporting both mechanistic studies and high-throughput screening assays.

Additionally, Colulintide can be integrated with multi-omic and computational analyses to map system-level effects. Its predictable pharmacodynamic profile allows correlation of molecular changes, such as transcriptomic, proteomic, or metabolomic alterations, with functional phenotypes in cells or animal models. This enables comprehensive investigation of peptide-mediated signaling networks and supports hypothesis-driven experimental design.

Overall, the mechanism of action of Colulintide Peptides Powder combines high receptor specificity, reproducible bioactivity, and versatility across in vitro and in vivo models, making it an ideal tool for mechanistic, pharmacological, and molecular research. Its high purity, GMP-grade quality, and customizable formulation ensure that researchers can perform precise, controlled studies to explore receptor-mediated pathways, enzymatic modulation, and systemic physiological responses.

Applications 

Colulintide Peptides Powder is suitable for a wide range of research applications due to its high purity, stability, and customizable formulation. In metabolic research, it can be used to study peptide-mediated modulation of glucose metabolism, insulin release, and intracellular signaling pathways. Its precise dosing and reproducibility allow researchers to examine acute and chronic effects, facilitating detailed mechanistic insights.

In pharmacology research, Colulintide supports investigation of agonist or antagonist activity, receptor binding affinity, and downstream functional outcomes in cell-based and animal models. Its high-purity formulation reduces off-target interactions, making it ideal for mechanistic pharmacological studies.

For neuroscience research, Colulintide enables examination of neuropeptide signaling, receptor-mediated synaptic modulation, and neuronal activity in vitro and in vivo. Its powder form allows accurate dosing in neuronal cultures or CNS studies, enabling reproducible exploration of peptide-driven behavioral and molecular changes.

The peptide is also valuable in drug discovery and high-throughput screening, supporting evaluation of sequence-specific activity, potency, and selectivity. Researchers can investigate combinatorial effects with other peptides, small molecules, or biologics in complex experimental systems.

Colulintide Peptides Powder supports structural biology and biochemical studies, including protein-peptide interactions, receptor binding, and enzyme modulation. Its lyophilized format ensures long-term stability and reproducible results across repeated experiments.

Moreover, Colulintide can be integrated with multi-omic analyses, including transcriptomics, proteomics, metabolomics, and lipidomics, to map global molecular responses. Overall, it provides a versatile platform for molecular, cellular, and in vivo studies, offering reproducibility, flexibility, and high-purity quality for cutting-edge research applications.

Research Models 

Colulintide Peptides Powder is compatible with a wide variety of research models, from isolated cells to whole-animal studies. In vitro applications include primary cells, immortalized cell lines, organoids, and tissue slices, where Colulintide can be used to study receptor-ligand interactions, signaling pathways, enzymatic modulation, and metabolic responses. Its high purity ensures consistent bioactivity and reproducible experimental results.

For metabolic studies, Colulintide can be applied to hepatocytes, adipocytes, pancreatic β-cells, or skeletal muscle cultures to evaluate effects on glucose uptake, hormone secretion, lipid metabolism, or mitochondrial activity. Dose-response studies are recommended to establish minimal effective concentrations while minimizing off-target effects.

In neuroscience research, neuronal cultures and brain slice preparations allow investigation of synaptic transmission, receptor activation, and intracellular signaling. Colulintide’s sequence specificity enables targeting of distinct receptor subtypes or signaling pathways, facilitating mechanistic studies of neuropeptide activity.

In vivo models, including rodents, allow evaluation of Colulintide’s pharmacological and physiological effects. Rodent studies may assess metabolic regulation, behavioral outcomes, tissue-specific signaling, and pharmacokinetics. The stable, high-purity powder ensures accurate dosing and reproducible responses.

Colulintide is suitable for multi-omic studies, enabling integration with transcriptomic, proteomic, metabolomic, and lipidomic analyses. Researchers can combine in vitro and in vivo experiments to generate comprehensive datasets for computational modeling, pathway mapping, and system-level understanding of peptide-mediated effects.

Overall, Colulintide Peptides Powder provides a robust, flexible platform for advanced experimental designs, supporting mechanistic research, high-throughput screening, and integrative multi-level analyses in metabolism, neuroscience, and pharmacology.

Experimental Design Considerations 

When designing experiments with Colulintide Peptides Powder, several factors should be considered to ensure reproducibility and reliable results. Dose selection should be based on target receptor affinity, tissue or cell sensitivity, and experimental model. For in vivo studies, species, age, metabolic state, and body weight must be considered to achieve consistent physiological responses. Acute and chronic dosing schedules should be optimized to prevent receptor desensitization, compensatory mechanisms, or peptide degradation over time.

In vitro studies require attention to cell density, receptor expression, media composition, and nutrient availability, as these factors influence peptide responsiveness. Dose-response experiments help determine the minimal effective concentration while minimizing off-target effects. The lyophilized powder allows precise reconstitution, facilitating accurate pipetting and consistent exposure across replicates.

Peptide handling is critical for maintaining bioactivity. Colulintide is sensitive to oxidation, deamidation, and adsorption to plastic surfaces, so it should be dissolved immediately prior to use, stored at 2–8 °C during handling, and aliquoted in low-binding tubes. Avoid repeated freeze-thaw cycles to preserve integrity and sterility.

For combinatorial or multi-peptide studies, careful timing and sequence of administration are essential to isolate Colulintide-specific effects. Co-treatment with inhibitors or receptor antagonists can help dissect downstream signaling pathways and validate mechanistic hypotheses.

Proper experimental design should also include appropriate controls, such as vehicle-treated samples or baseline measurements, to reduce variability and facilitate accurate interpretation. Adhering to these considerations ensures high reproducibility, maintains peptide integrity, and allows robust exploration of molecular mechanisms in metabolic, neurological, and pharmacological research.

Laboratory Safety & Handling Guidelines 

Colulintide Peptides Powder is intended solely for laboratory research use and must be handled under standard biosafety protocols. Researchers should wear personal protective equipment (PPE), including gloves, lab coats, and eye protection, to prevent accidental contact with skin or mucous membranes. Any exposure should be immediately treated with thorough washing, and institutional safety officers should be consulted if necessary.

Handling should occur in a designated work area or biosafety cabinet to minimize contamination risk. The lyophilized powder must be stored at 2–8 °C, protected from light and moisture, and reconstituted immediately prior to use. Use low-binding tubes and pipette tips to prevent adsorption and ensure consistent dosing. Repeated freeze-thaw cycles should be avoided, and aliquoting is recommended for long-term storage.

During experimental procedures, avoid generating aerosols or spills, especially when handling small volumes. All waste, including residual peptide, contaminated consumables, or buffer solutions, should be disposed of according to local biosafety and chemical disposal regulations. Surfaces and instruments should be decontaminated with 70% ethanol or other validated disinfectants after handling.

Colulintide Peptides Powder must never be used for human or veterinary applications, clinical interventions, or ingestion. Adherence to institutional SOPs for storage, dilution, and administration ensures safety and reproducibility. Maintaining documentation such as COA, MSDS, and batch QC reports supports compliance and traceability.

Following these guidelines preserves the bioactivity and sterility of Colulintide, reduces experimental variability, and ensures reliable results in both in vitro and in vivo studies.

Integration with Multi-Omic & Computational Studies 

Colulintide Peptides Powder is compatible with multi-omic approaches, including transcriptomics, proteomics, metabolomics, and lipidomics, enabling comprehensive mapping of peptide-mediated cellular and systemic responses. Its high purity and stability allow consistent receptor engagement and reproducible experimental data. Transcriptomic studies can reveal gene expression changes induced by Colulintide, while proteomic analyses can map downstream signaling events, post-translational modifications, and protein-protein interactions.

Metabolomic and lipidomic studies enable investigation of metabolic pathway modulation, energy homeostasis, and lipid signaling induced by Colulintide treatment. These datasets can be integrated with computational modeling to construct peptide-specific signaling networks, predict physiological outcomes, and identify key regulatory nodes for further study.

The powder’s lyophilized format allows precise reconstitution for high-throughput screening, multi-parameter assays, or combinatorial studies with other peptides or small molecules. Researchers can examine dose- and time-dependent molecular effects and correlate molecular signatures with functional outcomes such as enzyme activity, receptor signaling, or behavioral changes.

Integration with systems biology platforms supports modeling of organ-specific, multi-tissue, or systemic interactions. Multi-omic datasets generated using Colulintide can be leveraged for predictive computational analyses, enabling hypothesis-driven studies and mechanistic exploration of peptide biology at the molecular and cellular levels.

Overall, Colulintide Peptides Powder provides a versatile platform for combining experimental biology with computational analysis, supporting robust investigation of molecular, cellular, and physiological effects in metabolism, neuroscience, pharmacology, and systems biology research.

Side Effects (Research Observations Only)

In laboratory research, Colulintide Peptides Powder exhibits dose-dependent and reversible effects limited to in vitro and in vivo experimental models. In cell-based studies, researchers may observe modulation of receptor-mediated signaling, enzyme activity, or intracellular second messengers, reflecting the peptide’s intended molecular interactions. These effects are controlled, reproducible, and reversible under standard experimental conditions.

In animal studies, transient physiological responses such as mild changes in metabolism, hormone secretion, or behavioral activity may occur, depending on dose, administration route, and species. Localized injection site reactions have been reported in some rodent models, which are generally mild and reversible.

No systemic toxicity or irreversible cellular damage has been observed when Colulintide is used within recommended research dosing ranges. Researchers should monitor cell cultures or animals for any unexpected responses and adhere to recommended dosing and handling protocols. All side effects are strictly research observations and should not be extrapolated to human or veterinary use.

Keywords

Colulintide, Colulintide Peptides Powder, high-purity peptide, research peptide, GMP-grade peptide, wholesale peptide, OEM peptide powder, in vitro studies, in vivo studies, metabolic research, neuroscience research, pharmacology research, peptide signaling, multi-omic studies, peptide screening, custom peptides.

Shipping Guarantee

All shipments of Colulintide Peptides Powder use temperature-controlled packaging at 2–8 °C to maintain peptide stability and sterility. Moisture-protected containers and tamper-evident seals ensure integrity during transit. Global shipment tracking and batch documentation (COA, QC reports) accompany every order, guaranteeing reproducible delivery for research applications.

Trade Assurance

Factory-direct supply ensures high-purity GMP-grade Colulintide with customizable bulk quantities and OEM services. Each batch includes COA, MSDS, sterility, and endotoxin documentation. Guaranteed product quality and on-time delivery support institutional, commercial, and large-scale research projects.

Payment Support

We accept secure international payment methods including bank transfer, corporate credit, and online processing for research institutions. Flexible payment arrangements are available for multi-unit, long-term, and OEM orders, with all transactions documented for compliance and traceability.

Disclaimer

Colulintide Peptides Powder is for laboratory research use only. It is not for human or veterinary applications, clinical treatments, or ingestion. Users must follow institutional biosafety and regulatory protocols when handling this peptide. The product is intended solely as a research reagent and has not been evaluated for therapeutic purposes.

References

1. Peptide Research and Mechanisms
   Review of synthetic peptide applications, receptor interactions, and functional studies in molecular and pharmacological research.
   NCBI Bookshelf

2. PubChem: Synthetic Peptides Overview
   Chemical properties, bioactivity, and analytical validation of high-purity synthetic peptides.
   PubChem

3. UniProt: Peptide-Target Interaction Database
   Protein sequence, receptor binding, and functional annotations for peptide research.
   UniProt

4. Structural Insights into Synthetic Peptides
   Crystallography, binding studies, and mechanistic investigation of peptide interactions in research applications.
   RCSB PDB

5. High-Purity Peptide Manufacturing and Applications
   GMP-grade peptide synthesis, quality control, and research use in pharmacology and systems biology.
   ScienceDirect