Description

CR 665 (CAS No. 228546-92-7), also known as FE-200665 or JNJ 38488502, is an all-D-amino-acid peptide with high selectivity for peripheral ?-opioid receptors (over ? and ? receptors). Unlike conventional opioids, CR 665 offers potent analgesic effects with minimal central nervous system penetration and reduced gastrointestinal inhibition. Preclinical and early-phase human studies suggest strong efficacy in pain relief, particularly visceral pain, with minimal side effects such as respiratory depression or euphoria. Produced under GMP standards at 99.36% purity, CR 665 is designed for reliable and reproducible research performance. Intended strictly for laboratory research use only.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action
CR 665 selectively activates peripheral ?-opioid receptors (KOR), which are primarily located outside the central nervous system. This selective activation provides potent analgesia while avoiding common opioid-related central side effects such as respiratory depression, addiction, or gastrointestinal transit inhibition.

Research Applications

• Visceral Pain Models: Effective in preclinical and early human studies focusing on visceral nociception.

• Peripheral Pain Studies: Ideal for exploring analgesic mechanisms with limited CNS involvement.

• Selective Receptor Engagement: Minimizes off-target effects, making it valuable for pain pharmacology assays.

• Anti-inflammatory Research: May be used to study peripheral receptor modulation in inflammatory settings.

  

Side Effects (Research Context Only)

CR 665 is intended for in vitro and preclinical model research. In animal and early human studies, it demonstrated potent analgesic effects with minimal side effects—no significant CNS depression or gastrointestinal inhibition. No long-term safety data is available; standard laboratory safety protocols must be followed.

Disclaimer

CR 665 is strictly for laboratory research use only. It is not approved for clinical, therapeutic, or diagnostic use. Handle according to institutional safety guidelines.