Description

Product Description

Decapeptide-12 is a synthetic oligopeptide designed for advanced cosmetic and dermatological research focusing on skin brightening and anti-melanogenesis pathways. It functions as a competitive inhibitor of tyrosinase, the key enzyme responsible for melanin synthesis, and interacts specifically with the C-terminal residue of tyrosinase (Kd: 61.1 μM). Laboratory studies indicate an IC50 of 40 μM for mushroom tyrosinase inhibition, reflecting its potent enzymatic modulation capacity.

In addition to enzymatic inhibition, Decapeptide-12 has been shown to regulate gene transcription relevant to cellular longevity, including the upregulation of SIRT family genes, which are key regulators of cellular senescence and oxidative stress resistance. By modulating melanocyte activity, it effectively reduces melanin content in laboratory models, offering a controlled environment to study pigmentation, UV-induced melanogenesis, and hyperpigmentation mechanisms.

Biochemically, Decapeptide-12 is amphiphilic, facilitating penetration into epidermal layers in topical research formulations. This property enables effective interaction with melanocytes and keratinocytes, ensuring reproducible experimental outcomes. Its oligopeptide structure also allows for combinatorial studies with other skin-brightening peptides, such as hexapeptides or palmitoylated tripeptides, to evaluate synergistic effects on melanogenesis inhibition and barrier support.

Decapeptide-12 has been utilized extensively in cosmetic peptide research to explore melanogenesis pathways, inflammatory responses in skin models, and oxidative stress modulation. Researchers have reported its role in reducing melanin content while simultaneously supporting skin barrier maintenance, indicating potential utility in multi-functional anti-aging and pigmentation research models.

Its acetylated N-terminal and optimized peptide sequence contribute to enhanced stability, allowing for consistent experimental performance across various solvent systems and pH ranges. Furthermore, in vitro studies demonstrate that Decapeptide-12 can be integrated into serum, cream, and essence research formulations without compromising its bioactivity.

Product Specifications

Mechanism of Action

Decapeptide-12 functions as a bioactive tyrosinase inhibitor and melanogenesis modulator. Its mechanisms include enzymatic inhibition, gene transcription regulation, and cellular melanocyte modulation.

1. Tyrosinase Inhibition

Decapeptide-12 competitively inhibits tyrosinase activity by binding to its C-terminal residue, effectively reducing melanin synthesis in melanocytes. In vitro assays demonstrate an IC50 of 40 μM, making it a potent candidate for pigmentation research.

2. SIRT Gene Upregulation

The peptide increases transcription of sirtuin (SIRT) family genes, which are central to cellular stress response, senescence, and oxidative stress modulation. Upregulation of SIRT genes contributes to improved melanocyte resilience and mitigates premature pigmentation triggered by environmental stressors.

3. Melanin Reduction in Melanocytes

Decapeptide-12 has been shown to reduce melanin content in cultured melanocytes by directly inhibiting enzymatic activity and indirectly modulating melanogenesis-related gene expression. This dual action provides a comprehensive model for studying anti-melanogenesis pathways in skin research.

4. Anti-Inflammatory Effects

By regulating cytokine expression, including IL-6, TNF-α, and COX-2, Decapeptide-12 helps minimize inflammation-induced hyperpigmentation in melanocyte models. These effects make it suitable for research on pigmentation disorders associated with oxidative stress and inflammatory responses.

5. Synergistic Activity with Other Peptides

When combined with other cosmetic peptides, such as palmitoyl hexapeptides or acetyl tripeptides, Decapeptide-12 exhibits synergistic effects, enhancing overall pigment control while maintaining skin barrier function. This is particularly valuable in multi-component cosmetic peptide research formulations.

Side Effects

In controlled laboratory research, Decapeptide-12 exhibits minimal cytotoxicity at effective concentrations. No significant irritation or sensitization has been reported in reconstructed epidermal or melanocyte models.

As with all research peptides, concentration, solvent composition, and pH may affect experimental outcomes. Researchers should perform preliminary cytotoxicity and stability testing before formulation studies. The peptide should be stored protected from heat, light, and moisture. It is intended exclusively for research use.

Keywords

Decapeptide-12, tyrosinase inhibitor peptide, melanogenesis research, skin brightening peptide, anti-senescence peptide, cosmetic peptide, peptide supplier China, OEM & bulk peptide production, high-purity cosmetic peptides, factory peptide supplier

Shipping Guarantee

All Decapeptide-12 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Decapeptide-12 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Decapeptide-12 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Decapeptide-12 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.