描述
Product Specifications
Attribute | Details |
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Product Name | Dexketoprofen Trometamol Injection |
Generic Name | Dexketoprofen Trometamol |
CAS Number | (S)-Ketoprofen trometamol salt, proxy for 22071-15-4 en.wikipedia.org |
Molecular Formula | C??H??O?·C?H??NO? |
Molecular Weight | ~375.4?g/mol |
Dosage Form | Sterile aqueous solution for IV/IM injection |
Strength | 50?mg per 2?mL vial |
Pack Size | 1 vial per box |
Approval Number | H20233636 (China NMPA) |
Product Code | 86901599000245 |
Manufacturer | Nanjing Zhengke Pharmaceutical Co., Ltd. |
Storage | Store at 2–25?°C; protect from light |
Intended Use | Laboratory research only |
Mechanism of Action
Dexketoprofen is a selective and reversible inhibitor of COX-1 and COX-2 enzymes, reducing prostaglandin synthesis responsible for pain, inflammation, and fever. It is the pharmacologically active S-enantiomer, offering potent analgesia with a lower required dose and improved tolerability .
Research Applications & Pharmacology
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Postoperative and acute pain models: Shows fast and strong analgesia with opioid-sparing effects .
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NSAID comparative studies: Superior GI safety profile vs. racemic forms.
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Pharmacokinetics: Rapid absorption and onset; half-life around 2–3 hours, >99% protein binding; primarily excreted as glucuronide conjugates .
Safety Profile & Handling
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Adverse effects: Potential for nausea, dizziness, gastrointestinal irritation, injection-site discomfort. Generally well tolerated.
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Handling guidelines: Use aseptic technique. Monitor for renal and bleeding parameters in animal models. Dispose of waste per chemical safety protocols.
?? Research?Use Disclaimer
This product is intended solely for laboratory research. It is not approved for therapeutic, diagnostic, clinical, or veterinary applications. Misuse may result in safety hazards and invalidate experimental outcomes.
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