Description

Product Description

Diaminopropionoyl tripeptide-33 (CAS 1199495-15-2) is a small synthetic bioactive peptide recognized for its ability to protect skin cells from UVA-induced DNA damage and oxidative stress. It has become an increasingly valuable ingredient in cosmetic and dermatological research focused on photoprotection, anti-aging, and skin repair. By preventing DNA lesions and enhancing the expression of repair enzymes, Diaminopropionoyl tripeptide-33 supports cellular integrity, longevity, and resistance to environmental aggressors.

In modern skin biology, photoaging caused by ultraviolet (UV) radiation is one of the primary factors accelerating premature aging, wrinkles, and pigmentation irregularities. Diaminopropionoyl tripeptide-33 intervenes at the cellular level, mitigating the cascade of DNA damage and oxidative inflammation triggered by UVA exposure. This peptide not only shields keratinocytes and fibroblasts from oxidative stress but also promotes their repair mechanisms, improving overall skin resilience.

Studies on peptide-based photoprotection indicate that Diaminopropionoyl tripeptide-33 can effectively reduce thymine dimer formation and other mutagenic DNA adducts. By acting on cell signaling pathways related to apoptosis and DNA synthesis, it assists in restoring proper cell cycle balance and maintaining epidermal homeostasis. This makes it a promising candidate for cosmetic formulations that aim to prevent premature aging and maintain youthful skin function.

Beyond its photoprotective properties, Diaminopropionoyl tripeptide-33 is also appreciated for its compatibility with a wide range of cosmetic bases such as creams, serums, gels, and masks. Its molecular weight allows deep skin penetration, enabling targeted cellular activity without irritation. It can be incorporated into anti-aging, antioxidant, and skin-repair formulations designed for research into the long-term preservation of skin quality.

The compound demonstrates antioxidant synergy when combined with other peptides like acetyl hexapeptides and glutathione derivatives, enhancing total cellular defense capacity. Additionally, it supports collagen structure stability and improves fibroblast survival under UV exposure.

From a research perspective, Diaminopropionoyl tripeptide-33 represents a next-generation cosmeceutical molecule that bridges skin biology and molecular genetics, providing valuable insights into how bioactive peptides can influence DNA repair and skin rejuvenation.

Product Specifications

Mechanism of Action

Diaminopropionoyl tripeptide-33 functions through multiple cellular and molecular pathways aimed at protecting DNA integrity and maintaining cellular homeostasis. Its primary activity involves modulating the cellular response to oxidative stress and UV radiation, which are key triggers of photoaging and DNA mutation.

When exposed to UVA, skin cells undergo oxidative stress that leads to the formation of reactive oxygen species (ROS) and DNA lesions such as cyclobutane pyrimidine dimers (CPDs). Diaminopropionoyl tripeptide-33 reduces these effects by activating the DNA repair machinery, upregulating key enzymes responsible for base excision repair (BER) and nucleotide excision repair (NER). This process accelerates the correction of damaged nucleotides, thereby reducing mutation accumulation and enhancing genomic stability.

Another mechanism of Diaminopropionoyl tripeptide-33 is its ability to modulate the expression of stress-response proteins, including p53, catalase, and SOD. By maintaining balanced expression levels of these enzymes, the peptide minimizes cellular apoptosis while preserving fibroblast viability and extracellular matrix integrity.

Additionally, this tripeptide has been shown to strengthen mitochondrial function, allowing cells to recover energy balance after oxidative challenge. This contributes to improved cellular longevity and resilience against environmental stressors.

In anti-aging research, Diaminopropionoyl tripeptide-33 also acts as a signaling molecule that enhances extracellular matrix synthesis. It promotes collagen and elastin production, leading to improved skin elasticity and smoothness. It also supports the maintenance of epidermal thickness, delaying the onset of fine lines and sagging associated with intrinsic and extrinsic aging.

From a biochemical standpoint, Diaminopropionoyl tripeptide-33 is stable under formulation conditions, does not interfere with other peptides, and can synergize with antioxidants such as vitamin C, resveratrol, and glutathione to form a comprehensive anti-aging complex.

Overall, its mechanism combines antioxidant defense, DNA repair stimulation, and collagen support, making it an ideal research target for developing next-generation anti-aging formulations.

Side Effects

In laboratory and in vitro settings, Diaminopropionoyl tripeptide-33 has demonstrated excellent biocompatibility and low irritation potential. As a synthetic peptide, it does not contain allergenic proteins or heavy metals commonly associated with other cosmetic additives. However, as with any peptide research compound, appropriate handling and formulation studies are necessary to confirm its compatibility with specific delivery systems.

No cytotoxic or mutagenic effects have been reported in standard cell line models. The peptide exhibits high stability in aqueous and lipid environments, maintaining structural integrity under normal storage conditions.

Researchers should avoid high-concentration exposure that could alter cellular osmotic balance. It is recommended to conduct dose-dependent studies to optimize concentration and assess bioavailability in various formulations.

Diaminopropionoyl tripeptide-33 is intended strictly for research purposes and not for human or animal use. It should not be used in direct-to-consumer formulations without appropriate testing and regulatory approval.

Keywords

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Shipping Guarantee

All Diaminopropionoyl tripeptide-33 shipments are handled using validated cold-chain logistics to preserve peptide integrity. Each package is sealed in moisture-proof containers with secondary protective wrapping and continuous temperature monitoring. Products are shipped via express international couriers with full tracking and insurance coverage.

Trade Assurance

We Diaminopropionoyl tripeptide-33 ensure product authenticity, verified ≥99% purity, and compliance with analytical standards (HPLC, MS, and NMR). Each batch is supplied with a Certificate of Analysis (CoA). Our trade assurance policy guarantees replacement or refund for any deviation from listed specifications.

Payment Support

We Diaminopropionoyl tripeptide-33 provide flexible and secure global payment options to support international research transactions. Accepted payment methods include PayPal, major credit cards (Visa, MasterCard, American Express), telegraphic transfer (T/T), and cryptocurrencies (USDT, Bitcoin, Ethereum). All transactions are protected by industry-standard encryption and verified payment gateways to ensure confidentiality and fund security.

Disclaimer

All Diaminopropionoyl tripeptide-33 products listed are intended for laboratory research use only and not for human or veterinary use. They are not drugs, medical devices, or diagnostics and should not be administered to humans or animals. Researchers must handle all materials in accordance with institutional biosafety and chemical safety guidelines. The information provided is for scientific reference only and does not imply therapeutic efficacy, safety, or regulatory approval.