描述
Product Specifications
Attribute | Details |
---|---|
Product Name | Diclofenac Sodium Enteric?Coated Capsules (CCPC / Feiyan®) |
Generic Name | Diclofenac Sodium |
CAS Number | 15307?86?5 accessdata.fda.gov+1fulpharmaceutical.en.made-in-china.com+1fulpharmaceutical.en.made-in-china.com+3pubchem.ncbi.nlm.nih.gov+3en.wikipedia.org+3 |
Molecular Formula | C??H??Cl?NNaO? |
Molecular Weight | ~296.15?g/mol |
Dosage Form | Enteric?coated capsule |
Strength | 50?mg per capsule |
Pack Size | 30 capsules |
Approval Number | H19990333 (NMPA, China) |
Product Code | 86901751000076 |
Manufacturer | Dequan Pharmaceutical (Jiangsu) Co., Ltd. |
Barcode | 6924373920144 |
Storage | Store at 15–25?°C, dry environment |
Intended Use | Laboratory research use only |
Mechanism of Action
Diclofenac is a nonsteroidal anti?inflammatory drug (NSAID) that inhibits COX?1 and COX?2 enzymes, reducing prostaglandin synthesis for anti?inflammatory, analgesic, and antipyretic effects. Enteric coating prevents release in stomach acid, dissolving in the intestine instead.
Research Applications & Pharmacology
-
Pain & inflammation studies: Used in preclinical models of arthritis, muscle, joint, or headache pain .
-
Pharmacokinetics: Well absorbed orally, undergoes first?pass hepatic metabolism via CYP2C9/CYP3A4; elimination half?life ~1.2–2?hrs; distributed widely .
-
Bioequivalence studies: Enteric?coated forms show delayed but steady drug release compared to immediate?release forms.
Safety Profile & Handling
Preclinical & human side effects:
-
GI issues: potential ulceration, bleeding
-
Renal effects: fluid retention, increased creatinine in sensitive models
-
Hepatotoxicity: rare but serious liver injury cases
-
Cardiovascular: may raise blood pressure or worsen heart failure
Lab handling advice:
-
Administer orally with food or water to reduce gastric side effects
-
Monitor preclinical subjects for GI, renal, and liver markers
-
Use PPE and dispose of remaining capsules safely
?? Research?Use Disclaimer
This product is intended solely for laboratory research. It is not approved for any clinical, diagnostic, therapeutic, or veterinary use. Misuse may pose safety risks and invalidate research data.
评价
目前还没有评价