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Diclofenac Sodium Sustained?Release 100?mg ×?15 Tablets Wholesale price comparison
$3.60
Diclofenac sodium is a widely used nonsteroidal anti-inflammatory drug (NSAID) that provides analgesic, anti-inflammatory, and antipyretic effects by inhibiting COX?1 and COX?2 enzymes. This sustained?release formulation ensures prolonged effects for chronic inflammation and pain models. Packaged as 15 extended?release tablets of 100?mg each. Manufactured by Liaoning Fuyuan Pharmaceutical Co., Ltd. (NMPA Approval: H20194038; Product Code: 86901206000101; Barcode: 6937463302607).
?? For laboratory research use only?Please consult the staff for other purposes?
Description
Product Specifications
| Attribute | Details |
|---|---|
| Product Name | Diclofenac Sodium Sustained?Release Tablets |
| Generic Name | Diclofenac Sodium |
| CAS Number | 15307?86?5 (DrugBank DB00586) |
| Molecular Formula | C14H10Cl2NNaO2 |
| Molecular Weight | 296.15?g/mol (Wikipedia) |
| Dosage Form | Oral sustained?release tablet |
| Strength | 100?mg per tablet |
| Pack Size | 15 tablets (5 tablets × 3 boards) |
| Approval Number | H20194038 (China NMPA) |
| Product Code | 86901206000101 |
| Manufacturer | Liaoning Fuyuan Pharmaceutical Co., Ltd. |
| Barcode | 6937463302607 |
| Storage | Store at room temperature; protect from moisture and light |
| Intended Use | Laboratory research use only |
Mechanism of Action
Diclofenac functions by reversibly inhibiting cyclooxygenase enzymes COX-1 and COX-2, reducing prostaglandins (e.g., PGE?) that mediate inflammation, pain, and fever. It also modulates ion channels and reduces leukotriene activity, enhancing its analgesic profile .
Research Applications & Pharmacology
Inflammation and pain models: Effective in osteoarthritis, rheumatoid arthritis, nociception, and postoperative pain studies .
Pharmacokinetics:
Sustained-release tablets provide extended T_max (~4–8?hrs)
High protein binding (>99%); half-life ~1.2–2?hrs.
Metabolism: hepatic via CYP2C9; eliminated via urine (~65%) and bile (~35%) as conjugates.
Safety Profile & Key Precautions
Adverse effects: GI irritation (ulceration, bleeding), cardiovascular risk (hypertension, MI, stroke), renal impairment, elevated liver enzymes, headache, dizziness .
Handling in models:
Monitor renal, hepatic, and cardiovascular markers.
Administer with food or buffer to reduce gastric irritation.
Dispose of expired medication per hazardous waste protocols.
?? Research?Use Disclaimer
This product is intended only for laboratory research. It is neither approved nor intended for diagnostic, therapeutic, clinical, or veterinary use. Misuse may lead to serious side effects, compromise research outcomes, and violate regulations.
Additional information
| Weight | 1.1 kg |
|---|---|
| Dimensions | 18 × 16 × 18 cm |
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