Description
Product Description
Difelikefalin is a structurally defined synthetic peptide designed for scientific research focused on kappa opioid receptor (KOR)–mediated signaling pathways. Due to its selective receptor interaction profile, this peptide is commonly used in studies exploring peripheral opioid receptor biology and neuroimmune modulation mechanisms.
In laboratory settings, Difelikefalin serves as a valuable research tool for examining ligand–receptor interactions at the molecular level, particularly in peripheral nervous system models. Its peptide sequence and physicochemical properties support reproducible experimental outcomes in controlled in vitro and in vivo research environments.
The compound’s molecular design contributes to limited central nervous system penetration, which makes it especially relevant for mechanistic studies centered on peripheral receptor activity rather than central signaling effects. Researchers often employ this peptide to investigate downstream signaling cascades, receptor selectivity, and pathway-specific responses.
Supplied as a stable raw material, Difelikefalin allows flexible formulation and reconstitution according to experimental requirements. Each production batch is manufactured under controlled conditions and subjected to stringent quality testing to ensure consistency, purity, and structural integrity suitable for advanced research use.

Product Specifications
| Item | Description |
|---|---|
| Product Name | Difelikefalin |
| Synonyms | CR845 |
| CAS Number | 1221027-89-6 |
| Molecular Formula | C45H56N10O10 |
| Molecular Weight | ~906.0 g/mol |
| Amino Acid Sequence | Proprietary synthetic peptide sequence |
| Peptide Type | Linear synthetic peptide |
| Form | Lyophilized powder |
| Purity | ≥99% (HPLC) |
| Strength Options | Customizable (mg scale) |
| Appearance | White to off-white powder |
| Identity Verification | HPLC, MS |
| Solubility | Soluble in water or suitable buffers |
| Packaging | Sterile glass vial |
| Storage Condition | −20 °C, protected from light |
| Intended Use | Research use only |
Applications
Difelikefalin is primarily utilized in research programs focused on opioid receptor biology and peripheral signaling mechanisms.
Common research applications include:
Kappa opioid receptor signaling studies
Peripheral neurobiology research models
Ligand–receptor binding and selectivity assays
Neuroimmune interaction investigations
Pain pathway signaling mechanism studies
Structure–activity relationship analysis of opioid peptides
In vitro receptor activation and inhibition assays
Preclinical research model development
These applications position the peptide as a useful reference compound in studies requiring high receptor specificity and controlled experimental behavior.

Packaging
The product is supplied in sterile, sealed glass vials containing lyophilized peptide material. Bulk quantities, custom vial sizes, and OEM packaging options are available to support research institutions and peptide development programs.
Storage & Transportation
Store at −20 °C in a dry, light-protected environment. Cold-chain transportation is recommended to maintain product integrity during transit. Reconstituted solutions should be prepared under sterile laboratory conditions.
Inquiry & Technical Consultation
For Certificates of Analysis, batch-specific analytical reports, or technical documentation related to Difelikefalin, please contact us via the inquiry form. Professional technical support is available for qualified research users.
Disclaimer
This product is intended for research use only.
Not for human or veterinary use.
All handling and experimental applications must comply with applicable laboratory safety and regulatory requirements.


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