Description

Product Description

Doxorubicin Liposome Solution is a high-purity, laboratory-grade liposomal formulation designed exclusively for in vitro research and mechanistic studies. Encapsulation of doxorubicin within liposomes enhances chemical stability, improves solubility, and ensures reproducible behavior in controlled laboratory experiments. The solution form eliminates variability associated with lyophilized powders and provides immediate usability for molecular mechanism, structural, and biochemical pathway investigations.

This liposomal preparation is particularly suited for laboratories exploring drug-membrane interactions, liposome stability, and intracellular uptake simulations under fully controlled conditions. By providing a reproducible nanoscale delivery system, it enables detailed studies of lipid-drug interactions, liposomal release kinetics, and mechanistic modeling in synthetic or cell-free systems.

Researchers can utilize Doxorubicin Liposome Solution to examine liposome structural integrity, drug encapsulation efficiency, and chemical stability under varying environmental conditions, such as pH, ionic strength, or temperature. Analytical techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), high-performance liquid chromatography (HPLC), and fluorescence spectroscopy are commonly employed to assess these properties.

The solution also supports method development and validation, providing a reliable reagent for assay optimization, quality control studies, and high-throughput mechanistic experiments. Its consistent liposomal size distribution and encapsulation efficiency make it ideal for comparative studies across experimental conditions, including varying lipid compositions, buffer systems, and controlled stress environments.

Factory-controlled production ensures low-cost, bulk supply, with options for custom concentrations, batch-specific documentation, and research-grade quality verification. Each batch is confirmed for purity, liposome size distribution, and encapsulation efficiency, ensuring reproducibility and reliability in in vitro mechanistic studies.

By combining high purity, liposomal stability, and consistent production standards, Doxorubicin Liposome Solution is a versatile tool for laboratories investigating drug-lipid interactions, molecular mechanisms, and nanoscale delivery systems in controlled in vitro research settings.

Product Specifications

Notes

Doxorubicin Liposome Solution is produced under controlled factory conditions to maintain liposomal size uniformity, high encapsulation efficiency, and chemical stability. Its solution format enables immediate application in in vitro mechanistic studies, drug-membrane interaction assays, and structural analysis. Each batch undergoes rigorous quality control, including particle size assessment, encapsulation verification, and chemical integrity analysis to ensure reproducibility and reliability for research purposes.

Bulk and wholesale orders are supported with custom concentrations and packaging options to accommodate high-throughput mechanistic workflows and automated in vitro assays. Documentation such as Certificate of Analysis (CoA), MSDS, and batch-specific validation reports are provided to support laboratory compliance and experimental reproducibility.

Mechanism of Action

Doxorubicin Liposome Solution is a lipid-encapsulated formulation of doxorubicin designed for controlled in vitro mechanistic studies. Encapsulation within liposomes stabilizes the doxorubicin molecule, protects it from degradation, and allows researchers to investigate drug-lipid interactions, liposome stability, and controlled release mechanisms under laboratory conditions.

At the molecular level, doxorubicin interacts with synthetic membranes or purified protein constructs in vitro, providing a model to study binding dynamics, molecular encapsulation, and release kinetics. The liposomal carrier maintains consistent particle size and surface characteristics, enabling reproducible mechanistic observations across multiple experiments.

Researchers can monitor liposome integrity, drug release profiles, and membrane interactions using analytical techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), fluorescence spectroscopy, and HPLC. These controlled studies provide insights into nanoparticle-drug behavior, lipid bilayer interactions, and molecular release pathways, all within fully controlled experimental setups.

The liposomal formulation also allows systematic investigation of environmental factors such as pH, ionic strength, or temperature, which influence liposome stability and drug release. By adjusting these parameters, laboratories can model mechanistic pathways and understand lipid-drug dynamics at a molecular level.

Doxorubicin Liposome Solution is also useful for analytical method validation and model system development, serving as a reference standard in mechanistic in vitro studies. The combination of liposomal stability, high encapsulation efficiency, and chemical integrity ensures reproducible mechanistic data, supporting structural analysis, kinetic modeling, and in vitro biochemical assays.

Overall, this solution provides a robust, reliable platform for laboratories to explore liposomal drug behavior, controlled release mechanisms, and molecular interactions in fully controlled in vitro experimental settings.

Applications

Doxorubicin Liposome Solution is widely used in in vitro laboratory research due to its high-purity, stable liposomal formulation. Its solution form enables reproducible mechanistic studies without variability from reconstitution or solubility issues.

1. Liposome-Membrane Interaction Studies

The solution allows detailed examination of lipid bilayer dynamics, drug encapsulation, and membrane interaction mechanisms in synthetic or purified systems. Researchers can investigate drug-lipid affinity, bilayer penetration, and stability under controlled experimental conditions.

2. Drug Release Kinetics

Researchers can study controlled doxorubicin release from liposomes, modeling how environmental factors such as pH, ionic strength, and temperature affect release rates. This provides insights into mechanistic pathways of drug delivery systems in vitro.

3. Structural and Conformational Analysis

Doxorubicin Liposome Solution supports nanoparticle size distribution, morphology, and structural integrity studies. Techniques like TEM, DLS, and fluorescence spectroscopy enable researchers to monitor liposome stability and drug encapsulation consistency.

4. Analytical Method Development

Its stable liposomal formulation serves as a reference standard for validating analytical assays, including chromatography, spectrophotometry, and high-throughput screening methods, ensuring reproducibility in mechanistic studies.

5. High-Throughput Mechanistic Assays

The solution is compatible with automated in vitro platforms, supporting parallel testing of multiple conditions, such as varying lipid compositions, drug concentrations, or buffer systems, enhancing experimental throughput.

6. Integration with Computational Studies

Experimental data from liposome-drug interactions can be integrated with molecular modeling, docking simulations, or multi-omic analyses to refine mechanistic hypotheses and validate predictive models in vitro.

Overall, Doxorubicin Liposome Solution is a versatile tool for laboratories performing mechanistic, structural, and biochemical studies of lipid-drug interactions and nanoscale delivery systems in controlled environments.

Research Models

Doxorubicin Liposome Solution is designed for controlled in vitro research models, allowing laboratories to investigate lipid-drug interactions, liposomal stability, and mechanistic pathways at a molecular level. Its high-purity, stable liposomal formulation provides reproducible results, supporting detailed structure-function and release kinetics studies.

1. Synthetic Membrane Systems

Researchers use the solution in liposome-membrane interaction models with synthetic lipid bilayers or supported membranes. These models allow the study of drug encapsulation, bilayer insertion, and molecular dynamics without interference from cellular complexity.

2. Controlled Release and Kinetics Models

Time-course studies enable evaluation of doxorubicin release rates, environmental sensitivity, and stability under different pH, ionic strength, and temperature conditions. Such models provide precise insights into mechanistic pathways of liposomal drug release.

3. Structural Stability Models

Doxorubicin Liposome Solution supports nanoparticle characterization, including particle size distribution, morphology, and PEGylation effects (if applicable). Techniques such as dynamic light scattering (DLS), transmission electron microscopy (TEM), and fluorescence spectroscopy allow reproducible assessment of structural integrity.

4. Analytical Validation Models

The solution is frequently used to validate analytical platforms, including chromatography, high-throughput screening, and fluorescence-based detection. These models ensure reliability, reproducibility, and sensitivity for mechanistic studies.

5. Computational Integration Models

Experimental data from in vitro studies can be integrated with computational simulations, docking models, and multi-omic datasets to predict liposome-drug interactions, structural behavior, and kinetic properties. This combination strengthens mechanistic insights and supports predictive in vitro modeling.

Overall, these research models provide laboratories with a robust framework to study Doxorubicin Liposome Solution in mechanistic, structural, and kinetic contexts, ensuring reproducible and reliable in vitro results for molecular mechanism exploration.

Experimental Design Considerations

Designing experiments with Doxorubicin Liposome Solution requires careful planning to ensure accurate, reproducible, and mechanistically relevant results. Liposomal formulations are sensitive to environmental parameters, and proper experimental setup is critical for in vitro mechanistic studies.

1. Environmental Control

Maintain strict control of temperature, pH, ionic strength, and buffer composition. These factors influence liposome stability, drug encapsulation, and release kinetics, which are essential for generating reproducible mechanistic data.

2. Liposome Concentration and Integrity

Optimize liposome concentration based on assay requirements. Verify particle size, polydispersity, and encapsulation efficiency using analytical techniques such as DLS, TEM, or HPLC before experimental use to ensure consistency.

3. Time-Course and Kinetic Studies

Design experiments to monitor drug release rates, liposome-membrane interactions, and stability over time. Precise sampling intervals allow characterization of kinetic profiles and mechanistic pathways under controlled in vitro conditions.

4. Analytical Method Integration

Select suitable analytical methods, including fluorescence spectroscopy, HPLC, and nanoparticle tracking analysis, to detect structural changes, release kinetics, or lipid-drug interactions. Integrating analysis into the experimental plan ensures measurable and reproducible outcomes.

5. Replication and Statistical Planning

Include sufficient replicates and controls to validate observations. Detailed documentation of lot numbers, storage conditions, and handling procedures supports reproducibility across experiments and laboratories.

6. Computational and Predictive Modeling

Pair experimental results with in silico simulations or predictive models to validate mechanistic hypotheses and predict liposome behavior under varied conditions. This integration enhances understanding of drug-lipid dynamics and supports mechanistic modeling.

By following these guidelines, laboratories can design high-precision, reproducible in vitro experiments with Doxorubicin Liposome Solution, providing reliable mechanistic insights into liposomal drug behavior, release kinetics, and molecular interactions.

Laboratory Safety & Handling Guidelines

Doxorubicin Liposome Solution is a high-purity laboratory reagent intended exclusively for in vitro mechanistic and molecular research. Proper handling is essential to maintain liposome integrity, prevent contamination, and ensure safe laboratory operation.

1. Personal Protective Equipment (PPE)

Always wear gloves, lab coat, and eye protection when handling the solution. Conduct all work in a controlled laboratory environment to minimize exposure and prevent contamination.

2. Handling and Preparation

Use dedicated laboratory consumables to avoid cross-contamination. Pipette carefully to maintain liposome integrity and prevent aggregation or mechanical disruption of the vesicles.

3. Storage Conditions

Store the solution at 2–8°C in sealed, light-protected containers. Avoid repeated freeze-thaw cycles, high temperatures, or direct sunlight, which may compromise liposome stability and drug encapsulation.

4. Spill and Decontamination Procedures

In case of spills, contain immediately with laboratory-approved absorbents and clean surfaces using appropriate buffers or decontamination solutions. Dispose of all contaminated materials following institutional chemical waste protocols.

5. Documentation and Traceability

Maintain detailed records of lot numbers, storage conditions, and experimental usage. Accurate documentation ensures reproducibility and allows for troubleshooting across different experimental runs.

6. Laboratory Equipment

Use chemically compatible glassware, pipettes, and microplates dedicated for liposomal research. Avoid materials that may adsorb or destabilize liposomes to maintain experimental consistency.

Following these protocols ensures safe handling, reproducible data, and reliable mechanistic insights in laboratory-based in vitro studies.

Integration with Multi-Omic & Computational Studies

Doxorubicin Liposome Solution can be integrated into multi-omic workflows and computational modeling to provide detailed mechanistic insights into lipid-drug interactions, liposome stability, and molecular pathways in vitro. Its stable, high-purity formulation allows reproducible generation of experimental data suitable for correlation with proteomic, structural, and computational datasets.

1. Proteomic and Structural Integration

In vitro assays with Doxorubicin Liposome Solution can generate data on liposome-protein interactions, encapsulation efficiency, and structural dynamics. Proteomic and structural analysis methods, such as mass spectrometry and TEM, can be used to map binding events, validate mechanistic hypotheses, and support molecular pathway reconstruction.

2. Computational Modeling Applications

The predictable liposome behavior and drug release profiles enable integration with molecular docking, reaction pathway simulations, and predictive structural models. Researchers can compare computational predictions with experimental observations to refine mechanistic models and validate simulation accuracy.

3. Multi-Omic Correlation

Experimental in vitro data can be combined with transcriptomic, proteomic, or metabolomic datasets from controlled systems to identify mechanistic correlations. This approach supports reconstruction of molecular pathways and enables predictive modeling of liposome-drug interactions.

4. Analytical Method Validation

Doxorubicin Liposome Solution serves as a reference standard for validating analytical techniques, including chromatography, fluorescence-based assays, and nanoparticle characterization methods. Integration with computational models ensures robust interpretation and reproducibility.

Overall, the integration of Doxorubicin Liposome Solution into multi-omic and computational studies provides a powerful framework for in vitro laboratories to investigate liposomal drug behavior, molecular interactions, and mechanistic pathways under controlled experimental conditions.

Things to Note

1. Laboratory Use Only
   Doxorubicin Liposome Solution is intended exclusively for in vitro mechanistic, structural, and biochemical research. It is not suitable for human or veterinary use, clinical applications, or diagnostic purposes.

2. Handling and Safety
   Always wear appropriate PPE, including gloves, lab coat, and eye protection. Handle the solution in a controlled laboratory environment to maintain liposome integrity and prevent contamination.

3. Storage and Stability
   Store in sealed, light-protected containers at 2–8°C. Avoid repeated freeze-thaw cycles, heat, or light exposure, which can compromise liposome stability and drug encapsulation.

4. Analytical Verification
   Prior to experiments, confirm liposome size distribution, encapsulation efficiency, and chemical integrity using analytical techniques such as DLS, TEM, or HPLC to ensure reproducibility.

5. Waste Management
   Dispose of all residual solution and contaminated materials according to institutional chemical and biological waste protocols. Decontaminate surfaces and equipment after use.

6. Experimental Considerations
   Design experiments considering environmental sensitivity, liposome stability, and controlled release kinetics to ensure reliable and mechanistically meaningful results.

Following these notes ensures safe handling, reproducible results, and reliable mechanistic insights in laboratory-based in vitro studies.

Keywords

Doxorubicin Liposome Solution, high-purity liposomal doxorubicin, laboratory-grade liposome solution, in vitro mechanistic studies, liposome-drug interaction reagent, nanoparticle drug delivery research, controlled release kinetics, liposome stability analysis, biochemical pathway modeling, molecular mechanism research, high-throughput in vitro screening, structural dynamics reagent, proteomic and computational integration, factory-manufactured research reagent, bulk and wholesale laboratory supply, mechanistic pathway analysis reagent, controlled laboratory workflow reagent, high-purity solution for in vitro assays, analytical method validation liposome,Tumor (compound) Research, multi-omic integration reagent.

Shipping Guarantee

Factory-manufactured Doxorubicin Liposome Solution is packaged to maintain liposome integrity, chemical stability, and high-purity during transport. Bulk and wholesale orders are supported with secure shipment and tracking, ensuring the solution arrives in optimal condition for in vitro mechanistic and molecular studies. Shipments are handled to minimize exposure to heat, light, and contamination.

Trade Assurance

• Low-price wholesale supply directly from the factory.

• Bulk order customization available, including solution concentration and packaging options.

• Guaranteed high-purity liposomal solution for in vitro drug-lipid interaction and mechanistic studies.

• Factory-direct supply ensures consistent quality and reproducibility across multiple batches.

Payment Support

Multiple secure payment options are available to facilitate global laboratory procurement:

• PayPal

• Cryptocurrency

• Bank Transfer (TT)

• Credit Card

• Verified online payment systems

These options provide flexibility and security for bulk or wholesale orders, ensuring laboratories can obtain the product reliably and efficiently.

Disclaimer

Doxorubicin Liposome Solution is intended exclusively for laboratory research use. It is not approved for human or veterinary applications, diagnostic purposes, or therapeutic interventions. All experiments must be conducted in controlled in vitro, molecular, or mechanistic studies. Users must follow institutional safety protocols and chemical handling procedures. The product should never be administered to living organisms or used outside of research settings.

References

1. Ali Mohammadi Z., Aghamiri S. F., Zarrabi A., Talaie M. R. “Liposomal Doxorubicin Delivery Systems: Effects of Formulation and Processing Parameters on Drug Loading and Release Behavior.” Pharmaceutics, 2013; 5(1): 19‑39. (Link)

2. Haran G., Cohen R., Bar LK., Barenholz Y. “Encapsulation, Release, and Cytotoxicity of Doxorubicin Loaded in Liposomes, Micelles, and Metal-Organic Frameworks: A Review.” Pharmaceutics, 2022; 14(2): 254. (Link)

3. Barenholz Y. “Liposomal doxorubicin — review of preclinical and clinical studies.” PubMed review article on liposomal doxorubicin properties and pharmacokinetics. (Link)

4. Zhang et al. “Nanomorphology tuning in doxorubicin-loaded liposomes via cooling‑induced doxorubicin-crystallization and membrane phase transition.” Chemical Communications (RSC), 2025. (Link)

5. Sabeti B., Noordin M. I., Mohd S., Hashim R., Dahlan A., Javar H. A. “Development and Characterization of Liposomal Doxorubicin Hydrochloride with Palm Oil.” BioMed Research International, 2014; 2014:765426. (Link)