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Drotaverine Hydrochloride Injection 40?mg (No?Spa )
$1.00
No?Spa Drotaverine Hydrochloride Injection delivers 40?mg per 2?ml ampoule, with five ampoules per box. Produced by CHINOIN (Hungary) and approved under NMPA HJ20170302. Ideal for laboratory research involving smooth muscle spasm relief in visceral organs and vascular systems.
?? For laboratory and research use only. ?Please consult staff for other specifications and uses?
Description
Drotaverine is a benzylisoquinoline antispasmodic that selectively inhibits phosphodiesterase-4 (PDE4), resulting in increased cAMP and smooth muscle relaxation in the gastrointestinal tract, bile ducts, urinary system, and blood vessels. With its rapid onset of action and vasodilatory effects, it’s widely used in laboratory research for studying colic relief, biliary spasm, uterine relaxation, and vascular smooth muscle modulation.
Drotaverine Hydrochloride Injection Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Drotaverine Hydrochloride Injection (No?Spa / ???) |
| Active Ingredient | Drotaverine Hydrochloride |
| CAS Number | 14009?24?6 |
| Chemical Formula | C??H??NO? |
| Molecular Weight | ~397.5?g/mol |
| Formulation | Aqueous solution for injection, ampoule format |
| Strength per Ampoule | 40?mg in 2?ml |
| Pack Size | 5 ampoules per box |
| Dosage Form | Injectable solution |
| Approval No. | HJ20170302 |
| Drug Code | 86982100000015 |
| Manufacturer | CHINOIN Pharmaceutical and Chemical Works (Hungary) |
| Barcode | 6950641900174 |
| Storage Conditions | Store at 20–25?°C in a dry, dark place |
| Intended Use | Laboratory research on colic, smooth muscle spasm, vascular modulation |
Drotaverine Hydrochloride Injection Mechanism of Action
Drotaverine selectively inhibits PDE4, increasing cellular cAMP levels and activating PKA, which leads to myosin light chain kinase (MLCK) inhibition for smooth muscle relaxation. It also exhibits calcium-channel blocking effects, enhancing its antispasmodic and vasodilatory actions.
Research Applications
Gastro?intestinal colic: e.g., gallstones, gastritis, IBS
Ureteric and renal colic relief
Biliary tract spasms: cholecystitis, biliary colic
Gynecological spasms: dysmenorrhea, uterine contractions
Vascular smooth muscle relaxation and hemodynamic studies
Safety & Handling
Dosage & Use: In animal models, typically 40–80?mg slow IV or IM injection, 1–3 times daily .
Side Effects: Headache, dizziness, nausea; rare arrhythmia, hypotension, hypersensitivity.
Contraindications: Known allergy to drotaverine or sulfite preservatives, severe liver/kidney/heart failure.
Handling: Use standard lab PPE; avoid needle-stick and aerosol exposure.
Storage: Maintain at 20–25?°C, shield from light/moisture.
Core Keywords
drotaverine injection, No?Spa ampoule, 40mg drotaverine, CAS 14009?24?6, PDE?4 inhibitor smooth muscle relaxant, HJ20170302, antispasmodic injection, biliary spasm research, wholesale drotaverine
Research Use Disclaimer
This product is strictly for laboratory and research use. Not approved for therapeutic, diagnostic, clinical, or veterinary applications. Misuse may lead to legal or health consequences. Use only under approved institutional protocols.
Additional information
| Weight | 1 kg |
|---|---|
| Dimensions | 26 × 32 × 26 cm |
1 review for Drotaverine Hydrochloride Injection 40?mg (No?Spa )
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