Description

Dusquetide, also known by its code SGX-942, is a synthetic 5-amino-acid peptide (R-I-V-P-A-NH?) acting as an innate defense regulator. It binds to the p62 (sequestosome-1) ZZ domain and modulates immune signaling pathways including MAPK p38 and C/EBP, shifting responses from pro-inflammatory to anti-inflammatory while enhancing bacterial clearance and accelerating tissue healing. It has shown significant efficacy in reducing oral mucositis duration in preclinical and Phase 2a clinical studies. Produced under GMP standards with ?99.77% purity, Dusquetide is optimized for immunology and mucosal injury research models. For laboratory research use only.

Product Specifications

Mechanism of Action & Research Applications

Dusquetide functions as an innate defense regulator by binding to the p62 adaptor protein, modulating key immune pathways like MAPK p38 and C/EBP. This biochemical shift fosters anti-inflammatory responses and enhanced clearance of pathogens. Preclinical and clinical research demonstrated its ability to significantly reduce oral mucositis duration and improve mucosal healing. This makes it highly valuable in research areas such as immunology, mucosal injury, infection response, and innate immune system regulation. For laboratory research use only.

Side Effects (For Reference Only in Models)

In experimental models, Dusquetide has demonstrated immune modulation without noted toxicity, and there is no evidence of tumor growth exacerbation. In animal models, Dusquetide did not worsen survival and even suggested improved outcomes when combined with radiation in tumor studies. These findings serve as a reference for experimental design. For laboratory research use only.

Disclaimer

Dusquetide is provided strictly for laboratory research use only. It is not approved for human or veterinary use. All handling must adhere to institutional safety protocols.