描述
Dynorphin A (also referred to as dynorphin?(1–17)) is a naturally occurring opioid peptide derived from prodynorphin. It functions as a high-potency agonist at ?-opioid receptors (KOR), with greater selectivity over mu (MOR) and delta (DOR) opioid receptors. As an endogenous neuropeptide, Dynorphin A plays critical roles in pain modulation, mood regulation, stress response, and neural plasticity.
This GMP-manufactured, research-grade product offers reliable reproducibility with a purity of ?95.18%. It’s perfect for advanced studies in opioid signaling pathways, addiction mechanisms, and neuroinflammation.
For laboratory research use only. Not for clinical, therapeutic, or veterinary use.
Product Specifications
Feature | Detail |
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Product Name | Dynorphin A |
CAS Number | 80448?90?4 |
Purity | ?95.18% (HPLC) |
Molecular Weight | ~2147.5 Da |
Molecular Formula | C??H???N??O?? |
Peptide Sequence | Tyr–Gly–Gly–Phe–Leu–Arg–Arg–Ile–Arg–Pro–Lys–Leu–Lys–Trp–Asp–Asn–Gln |
Appearance | White to off-white lyophilized powder |
Solubility | Soluble in water (~0.8 mg/mL) |
Storage Conditions | ?20?°C, protect from light and moisture |
Manufacturing | GMP-compliant facility |
Intended Use | Laboratory research only |
Mechanism of Action & Research Applications
Dynorphin A is a highly potent ?-opioid receptor (KOR) agonist; it also exhibits lower affinity for ? and ? opioid receptors. It plays fundamental roles in:
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Modulating pain pathways in the central nervous system
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Regulating mood, emotional behaviors, and stress responses
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Influencing synaptic plasticity, such as inhibition of long-term potentiation in hippocampal circuits
This makes it invaluable for research in neuropharmacology, pain physiology, addiction, mood disorders, and neurodegeneration.
Side Effects (Research Context Only)
In experimental models, Dynorphin A may lead to:
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KOR-mediated analgesia, dysphoria, or altered emotional states
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Modulation of neurotransmitter release, including dopamine
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Changes in synaptic strength or plasticity in neural circuits
These outcomes are context-dependent and observed in nonclinical laboratory studies.
Disclaimer
This product is intended strictly for laboratory research use only. It is not intended for human or veterinary use, diagnosis, or treatment. Use must comply with appropriate institutional and legal protocols.
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