Emfilermin | CAS No. 159075-60-2

Description

Product Description

Emfilermin (CAS 159075-60-2) is a recombinant human leukemia inhibitory factor (LIF), a pleiotropic cytokine in the interleukin-6 (IL-6) family. LIF is a multifunctional protein involved in cell growth, survival, and differentiation, as well as immune modulation. The recombinant form, Emfilermin, has been developed for research purposes in areas ranging from chemotherapy-induced peripheral neuropathy to embryo implantation biology and stem cell research.

Background and Biological Role

Leukemia inhibitory factor (LIF) was first identified as a factor capable of inducing terminal differentiation in myeloid leukemia cells. Since then, it has been recognized as a critical regulator in multiple biological systems:

• Neurobiology: LIF promotes neuronal survival, axonal regeneration, and protection against neurotoxic injury.

• Reproductive Medicine: It plays a crucial role in endometrial receptivity and embryo implantation.

• Cancer Biology: LIF contributes to tumor–immune interactions, angiogenesis, and cancer cell resistance.

• Hematopoiesis: It regulates survival and differentiation of hematopoietic progenitors.

Research Relevance

1. Chemotherapy-Induced Peripheral Neuropathy (CIPN)

   • Chemotherapy agents such as platinum derivatives, taxanes, and vinca alkaloids often cause neurotoxicity.

   • Emfilermin is studied for its ability to protect neurons, reduce apoptosis, and restore nerve function.

2. Stem Cell Biology

   • LIF maintains pluripotency in murine embryonic stem cells via the STAT3 signaling pathway.

   • Emfilermin is widely used to understand pluripotency maintenance and differentiation.

3. Reproductive Biology

   • LIF is essential for embryo implantation. Emfilermin provides a tool for studying uterine biology, fertility, and early pregnancy loss.

4. Cancer and Immunology

   • Research explores LIF’s dual role in tumor promotion and immune regulation.

   • Emfilermin is used as a model to study how modulating cytokine signaling influences tumor biology.

Product Specifications

Notes

• Validated by SDS-PAGE and Western blotting.

• Endotoxin-free preparations available.

• Supplied in sterile vials.

Mechanism of Action

Emfilermin functions through LIF receptor (LIFR) and gp130 heterodimer signaling.

1. Receptor Binding

   • LIF binds to LIFR, which forms a heterodimer with gp130, activating intracellular signaling cascades.

2. JAK/STAT3 Pathway

   • Central to pluripotency and survival.

   • Promotes stem cell maintenance and prevents apoptosis.

3. MAPK/ERK Pathway

   • Drives differentiation in certain cell lineages.

   • Contributes to neuronal regeneration and immune modulation.

4. PI3K/AKT Pathway

   • Enhances cell survival, neuroprotection, and anti-apoptotic activity.

5. Immune Modulation

   • Alters cytokine release, regulates inflammation, and influences tumor–immune interactions.

6. Neuroprotection

   • In models of CIPN, Emfilermin reduces neuronal apoptosis, protects sensory neurons, and supports axonal regeneration.

7. Reproductive Role

   • Enhances uterine receptivity via regulation of adhesion molecules and cytokine signaling.

     

Side Effects

Research Observations

• In laboratory models, Emfilermin has shown low systemic toxicity.

• Effects depend on dosage and exposure time.

Potential Risks

• Overactivation of LIF pathways may contribute to pro-tumorigenic activity in some models.

• Possible immune system modulation, requiring careful interpretation of results.

• At high concentrations, may induce differentiation in unintended cell types.

Laboratory Safety Notes

• Intended for research use only.

• Handle under sterile conditions.

• Store at recommended conditions to prevent degradation.

Disclaimer

This product is intended for research purposes only. Emfilermin is not approved for human therapeutic or diagnostic use.

Keywords

Emfilermin, CAS 159075-60-2, recombinant human LIF, leukemia inhibitory factor, chemotherapy-induced peripheral neuropathy, neuroprotection cytokine, stem cell pluripotency, reproductive biology cytokine, cancer research cytokine.china low price supplier 

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