Description
Exendin?4 acetate is a 39?amino?acid GLP?1 receptor agonist peptide modeled after a natural peptide in Gila monster venom. Its prolonged action enhances insulinotropic effects over native GLP?1, making it valuable for type 2 diabetes, weight regulation, and neuroprotection research. Preclinical studies demonstrate improved endothelial nitric oxide production, ?-cell survival, and glucose metabolism. Manufactured under GMP with 99.91% purity for consistent research quality.
Product Specifications
| Parameter | Details |
|---|---|
| Product Name | Exendin?4 Acetate |
| Synonyms | Exenatide acetate |
| CAS Number | 914454-01-6 |
| Purity | ?99.91% (HPLC) |
| Peptide Length | 39 amino acids |
| IC?? (GLP?1R) | ~3.22?nM |
| Appearance | White to off?white powder |
| Solubility | Soluble in DMSO and aqueous buffers |
| Storage | –20?°C, light- and moisture-protected |
| GMP Compliance | Yes |
| Intended Use | Laboratory research only |
Mechanism of Action & Research Applications
Exendin?4 acetate activates the GLP?1 receptor, increasing cAMP and enhancing insulin secretion while inhibiting glucagon. It slows gastric emptying, supports ?-cell survival, promotes endothelial NO synthesis, and shows neuroprotective effects. Used in studies on diabetes, obesity, cardiovascular health, and neurodegeneration.
Side Effects (For Research Context Only)
In laboratory models, it may cause delayed gastric emptying, mild blood pressure reduction, and potential liver or pancreatic changes under high or prolonged dosing.
Disclaimer
Exendin?4 Acetate is for laboratory research use only and not for human or veterinary applications.


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