Ezatiostat (CAS: 902135-91-5) – Purity 99.71% | GMP Factory

描述

Ezatiostat, also known as TLK199 or TER199 free base, is a tripeptide analog of glutathione that acts as a selective glutathione S-transferase P1-1 (GSTP1) inhibitor. By inhibiting GSTP1, Ezatiostat disrupts the negative regulation of the JNK (c-Jun N-terminal kinase) signaling pathway, leading to increased apoptosis in malignant cells and stimulating bone marrow progenitor proliferation and lymphocyte production.

Due to its dual activity in hematopoiesis and cellular signaling, Ezatiostat is widely used in myelodysplastic syndrome (MDS) and oncology-related research. This product is manufactured in a GMP-compliant facility, ensuring consistent purity and high-quality standards for laboratory use.

For laboratory research only. Not intended for human or veterinary use.

Product Specifications

Mechanism of Action & Research Applications

Ezatiostat works by inhibiting glutathione S-transferase P1-1 (GSTP1), a key enzyme that interacts with the JNK signaling pathway. This inhibition allows JNK to become active, which leads to enhanced apoptosis in cancerous cells and stimulation of hematopoietic progenitors. The compound is also known to induce lymphocyte expansion, making it valuable in hematological and immunological research.

Research Applications:

• Myelodysplastic syndrome (MDS) models

• Hematopoietic stem and progenitor cell studies

• JNK signaling and apoptosis research

• Oncology and immunotherapy drug screening

• Bone marrow function and regeneration models

Side Effects

In experimental models, Ezatiostat has demonstrated:

• Activation of apoptosis pathways via JNK

• Proliferation of hematopoietic cells

• Potential cytotoxicity at high concentrations

All data reflect effects under laboratory conditions only.

Disclaimer

Ezatiostat is intended for laboratory research use only. It is not approved for clinical, diagnostic, or therapeutic use in humans or animals. This product is manufactured in a GMP-compliant facility for high-quality research purposes only.