描述
Ezetimibe is a selective cholesterol absorption inhibitor that blocks the Niemann-Pick C1-Like 1 (NPC1L1) protein on the intestinal brush border, reducing the uptake of dietary and biliary cholesterol. It is widely used in research focusing on lipid metabolism, cardiovascular diseases, and novel lipid-lowering therapeutics.
Each tablet contains 10mg of ezetimibe, formulated for consistent dosing in preclinical studies. Packaged as 10 tablets per blister pack, this product supports a range of experimental applications including in vitro cellular assays and in vivo pharmacokinetic and pharmacodynamic investigations.
Manufactured by Zhejiang Nuode Pharmaceutical Co., Ltd., the product is approved by China’s National Medical Products Administration (NMPA) with approval number H20243253 and product code 86983521000318.
?? For laboratory research use only. Not for human or veterinary use.
Product Specifications
Parameter | Details |
---|---|
Product Name | Ezetimibe Tablets (Nodexhang) |
Generic Name | Ezetimibe |
CAS Number | 163222-33-1 |
Molecular Formula | C24H21F2NO3 |
Molecular Weight | 409.43 g/mol |
Dosage Form | Tablets |
Strength | 10mg per tablet |
Quantity | 10 tablets per blister pack, 1 blister per box |
Approval Number | H20243253 (China NMPA) |
Product Code | 86983521000318 |
Manufacturer | Zhejiang Nuode Pharmaceutical Co., Ltd. |
Barcode | 6974198631701 |
Intended Use | Laboratory research only |
Storage Conditions | Store sealed below 25°C, away from moisture and light |
Mechanism & Research Applications
Ezetimibe selectively inhibits the NPC1L1 transporter protein in the intestinal lining, preventing the absorption of cholesterol. This mechanism makes it a valuable research tool in studies of cholesterol metabolism and cardiovascular health.
Its applications include experimental evaluation of lipid-lowering agents, investigation of cholesterol homeostasis, and drug interaction studies related to cholesterol transport and metabolism.
Ezetimibe tablets are also used for in vitro assays with hepatocytes and enterocytes as well as in vivo pharmacokinetic modeling in preclinical research.
Safety & Handling
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Use Restriction: For laboratory research only; not for clinical or veterinary use.
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Protective Equipment: Gloves, lab coat, and eye protection recommended.
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Storage: Store sealed in a cool, dry place below 25°C, away from light.
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Disposal: Follow institutional regulations for chemical and pharmaceutical waste.
Research Use Disclaimer
This product is intended exclusively for laboratory research purposes. It is not approved for clinical, therapeutic, diagnostic, or veterinary applications. Misuse may pose safety and legal risks. Always follow local regulations and institutional biosafety protocols.
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