Fertirelin Acetate (CAS No. 66002-66-2) | High-Purity GnRH/LH-RH Analogue

描述

Product Description

Fertirelin acetate is a synthetic peptide analogue of gonadotropin-releasing hormone (GnRH, also known as luteinizing hormone-releasing hormone, LH-RH). As a decapeptide derivative, it mimics the action of endogenous GnRH by binding to pituitary receptors and stimulating the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This makes it a critical tool compound in reproductive physiology and veterinary endocrinology.

Originally designed to enhance stability and potency compared with natural GnRH, Fertirelin acetate exhibits greater resistance to enzymatic degradation and has higher receptor affinity, resulting in a more pronounced gonadotropin-releasing effect. This property makes it particularly useful in bovine reproduction research, where it is applied in the study of:

• Ovarian follicular cysts

• Ovulation induction

• Estrus synchronization

• Improvement of reproductive efficiency in dairy herds

Relevance in Veterinary Reproductive Biology

Bovine follicular cysts are a leading cause of infertility in dairy cattle, leading to economic losses in the livestock industry. Fertirelin acetate, by stimulating the hypothalamic-pituitary-gonadal (HPG) axis, enables researchers to:

• Induce ovulation in cystic cows

• Reset ovarian cyclicity

• Improve fertility outcomes in affected animals

Additionally, its ability to trigger LH and FSH release makes Fertirelin acetate a model compound for investigating pituitary responsiveness, ovarian physiology, and feedback mechanisms in endocrine regulation.

Broader Research Applications

Although most widely studied in bovine models, Fertirelin acetate is also used to explore:

• Mechanisms of GnRH receptor activation

• Comparative endocrinology across species

• Pharmacokinetics and metabolism of peptide analogues

• Drug development for reproductive disorders

Its veterinary importance makes it a benchmark GnRH analogue, alongside compounds such as buserelin, gonadorelin, and leuprolide.

Product Specifications

Notes on Specifications

• Peptide Properties: Fertirelin acetate maintains the core GnRH sequence with substitutions that enhance activity and stability.

• Analytical Testing: Purity is confirmed by HPLC and MS analysis.

• Formulation: Lyophilized for long-term stability; reconstitution recommended in sterile buffers.

• End-Use: For laboratory research and veterinary physiology studies only.

Mechanism of Action & Research Applications

Mechanism of Action

Fertirelin acetate functions as a potent GnRH receptor agonist. When administered in a research setting, it:

1. Binds to GnRH receptors on the anterior pituitary gland.

2. Triggers intracellular signaling via Gq-protein activation and IP₃/DAG pathways.

3. Induces the release of LH and FSH from pituitary gonadotrophs.

4. Stimulates downstream gonadal steroidogenesis and follicular maturation.

Its enhanced receptor binding compared to natural GnRH provides stronger and more sustained gonadotropin release, critical for overcoming endocrine dysregulation in ovarian cyst pathology.

Research Applications

1. Bovine Follicular Cysts – Correcting abnormal ovarian cycles by inducing ovulation.

2. Ovulation Induction – Studying LH surge and follicle rupture timing.

3. Estrus Synchronization – Useful in herd reproductive management models.

4. Comparative Endocrinology – Investigating cross-species activity of GnRH analogues.

5. Drug Development – Benchmark molecule for designing long-acting GnRH agonists.

6. Pituitary Studies – Mapping receptor sensitivity and desensitization mechanisms.

7. Veterinary Physiology – Understanding infertility causes in large animal species.

Translational Insights

While primarily a veterinary research compound, Fertirelin acetate contributes to the larger field of reproductive biology by enabling scientists to map GnRH analogues’ structure-activity relationships, paving the way for therapeutics in both animal and human fertility research.

Side Effects (For Research Context Only)

Research observations suggest potential side effects associated with Fertirelin acetate administration in veterinary studies:

1. Transient Hormonal Imbalances – Overstimulation of LH and FSH may disrupt normal ovarian cycles.

2. Injection Site Reactions – Local irritation, swelling, or mild inflammation.

3. Reduced Efficacy with Repeated Use – Possible receptor desensitization or downregulation.

4. Species-Specific Responses – Differences in GnRH receptor sensitivity across cattle, swine, and other animals.

5. Endocrine Feedback Alterations – Prolonged exposure may suppress natural GnRH pulsatility.

6. Behavioral Effects – Observed changes in estrous behavior in bovine research models.

These potential effects highlight the need for controlled laboratory studies, ensuring accurate data interpretation.

Disclaimer

For laboratory research use only. Not intended for human or veterinary therapeutic use.

Keywords

• Fertirelin acetate

• Fertirelin acetate CAS 66002-66-2

• GnRH analogue peptide

• LH-RH analogue peptide

• Fertirelin acetate bovine cyst research

• Veterinary reproduction research peptide

• Ovarian cyst reversal peptide

• Estrus synchronization analogue

• Peptide for reproductive endocrinology studies

• GMP-grade veterinary research peptides