描述
Product Specifications
Attribute | Details |
---|---|
Product Name | Finasteride Tablets (Qianolin® / Xiangjiang) |
Generic Name | Finasteride |
CAS Number | 98319?26?7 (zh.wikipedia.org) |
Molecular Formula | C??H??N?O? |
Molecular Weight | ~372.5?g/mol (free base) |
Dosage Form | Film-coated oral tablet |
Strength | 5?mg per tablet |
Pack Size | 60 tablets per bottle |
Approval No. | China NMPA H20040333 |
Product Code | 86904960000424 |
Manufacturer | Hunan Qianjin Xiangjiang Pharmaceutical Co., Ltd. |
Barcode | 6934805201703 |
Storage Conditions | Store at 15–25?°C; keep dry and away from light |
Intended Use | Laboratory/preclinical research only |
Mechanism of Action
Finasteride is a competitive inhibitor of Type II (and III) 5?-reductase, blocking the conversion of testosterone to DHT and reducing serum and tissue levels of DHT by approximately 70%–90% . This enzyme blockade is central to androgenic alopecia and BPH models.
Research Applications & Pharmacology
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Androgenic Alopecia Studies: Suppresses follicular DHT, slowing hair loss and promoting regrowth .
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Benign Prostatic Hyperplasia (BPH) Models: Reduces prostate volume, urinary retention, and delays surgical intervention.
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Pharmacokinetics: ~90% protein bound, bioavailability ~65%, half-life ~5–6?hours in adults (longer in elderly); metabolized by liver (CYP3A4), excreted in feces (57%) & urine (40%) .
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Comparative 5-ARI Research: Finasteride inhibits Type II, leading to ~70% DHT reduction, vs. dutasteride (~95%) .
Safety Profile & Handling
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Common Adverse Effects (in vivo): Rare sexual dysfunction, decreased libido, ejaculation disorders .
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Serious Risks: Potential depression, self-harm (in elderly), gynecomastia (~1.3%) .
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Contraindications: Not for use by females, especially pregnant, due to teratogenic DHT suppression.
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Handling Advice: Store under recommended temperature; use PPE when opening; discard per lab biosafety guidelines.
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