Description

Product Description

FIZZ-1 (32-51) (Mouse), also known as Resistin-Like Molecule Alpha (RELMα) fragment, is a cysteine-rich secretory peptide predominantly expressed in macrophages, bronchial epithelial cells, and type II alveolar epithelial cells (AECs) during allergic airway inflammation. This peptide plays a crucial role in modulating immune cell activity, fibroblast apoptosis, and extracellular matrix remodeling.

Originally identified in murine models of asthma and pulmonary inflammation, FIZZ-1 (32-51) (Mouse) represents an essential mediator of the Th2 immune response. It is a fragment corresponding to amino acid residues 32–51 of the full-length FIZZ-1 protein, retaining bioactive structural motifs, including conserved disulfide bridges that stabilize its cysteine-rich domain.

Biological Context

During allergic airway inflammation, FIZZ-1 (32-51) is upregulated by IL-4 and IL-13, two key Th2 cytokines, leading to enhanced secretion by activated macrophages and airway epithelial cells. It acts as a signaling peptide that mediates communication between immune and structural cells of the lung, contributing to fibrotic remodeling and inflammatory regulation.

In vitro studies show that FIZZ-1 (32-51) inhibits fibroblast apoptosis, supporting tissue integrity under inflammatory stress. It also modulates collagen production and myofibroblast differentiation, implicating it in both protective repair and pathological fibrosis depending on the inflammatory context.

Research Applications

• Allergic airway inflammation: FIZZ-1 (32-51) regulates immune responses in asthma and pneumonia models.

• Fibrosis studies: Inhibits fibroblast apoptosis and influences ECM remodeling.

• Immunology: Serves as a Th2 cytokine-regulated peptide for macrophage activation research.

• Lung epithelial biology: Useful for examining epithelial–mesenchymal interactions during inflammation.

Through these biological effects, FIZZ-1 (32-51) (Mouse) is a powerful molecular tool for exploring immune-driven lung pathophysiology and fibrotic disease progression.

Product Specifications

Mechanism of Action

FIZZ-1 (32-51) (Mouse) acts as a cytokine-like signaling peptide involved in Th2-mediated inflammation and fibroblast regulation.

1. Th2 Cytokine Induction Pathway

FIZZ-1 (32-51) is transcriptionally induced by IL-4 and IL-13, two cytokines central to type II immune responses. It acts downstream of STAT6 signaling, amplifying macrophage and epithelial cell activation.

2. Antiapoptotic Effects on Lung Fibroblasts

This peptide prevents apoptosis in fibroblasts by modulating Bcl-2/Bax expression ratios and inhibiting caspase-3 activation. The result is enhanced fibroblast survival, contributing to lung repair following allergen exposure.

3. Macrophage and Epithelial Crosstalk

FIZZ-1 facilitates intercellular communication between macrophages and epithelial cells. In allergic models, it acts as an autocrine and paracrine regulator, influencing chemokine secretion and macrophage polarization toward an alternatively activated (M2) phenotype.

4. Extracellular Matrix Regulation

By promoting fibroblast proliferation and collagen synthesis, FIZZ-1 (32-51) contributes to tissue remodeling processes. These effects are context-dependent — they may be protective in acute inflammation but fibrotic in chronic conditions.

5. Potential Therapeutic Insight

Due to its dual activity (antiapoptotic yet profibrotic), FIZZ-1 (32-51) represents an intriguing target for modulating fibrotic lung diseases, asthma, and hypersensitivity pneumonitis.

Side Effects

As a research peptide, FIZZ-1 (32-51) (Mouse) is not approved for human use. Reported experimental considerations include:

• Potential fibroblast overstimulation in chronic exposure models.

• Minor cytotoxicity at supraphysiological concentrations.

• Possible pro-fibrotic activity under prolonged treatment conditions.

Handle with gloves and avoid direct inhalation or contact.

Disclaimer

FIZZ-1 (32-51) (Mouse) is supplied for laboratory research use only. Not intended for human or veterinary applications. Data provided are for scientific and educational purposes only.

Keywords

FIZZ-1 (32-51) mouse, RELMα peptide, cysteine-rich peptide, allergic airway inflammation, fibroblast apoptosis inhibitor, Th2 cytokine peptide, asthma research peptide, fibrosis peptide, pulmonary inflammation model, epithelial–macrophage signaling.

Shipping Guarantee

All peptides are shipped under controlled temperature and moisture-protected packaging, accompanied by analytical data (HPLC, MS). Global shipping standards ensure product stability.

Transaction Guarantee

Each product batch is validated with a Certificate of Analysis (COA). We guarantee full refund or replacement for any shipment damage or quality deviation.