Description
Product Specifications
| Specification | Description |
|---|---|
| Product Name | Flumazenil Injection (Henan Runhong) |
| Generic Name | Flumazenil |
| CAS Number | 78755?81?4 |
| Molecular Formula | C??H??FN?O? |
| Molecular Weight | ~303.29?g/mol |
| Formulation | Lyophilized sterile powder for injection, reconstitute with sterile diluent |
| Strength | 0.5?mg per 5?mL vial |
| Pack Size | 1 vial per box (additional info by request) |
| Approval Number | H20254517 (NMPA, China) |
| Manufacturer | Henan Runhong Pharmaceutical Co., Ltd. |
| Storage Conditions | Store at 2–8?°C; protect from light and moisture |
| Intended Use | For laboratory research only |
Mechanism of Action
Flumazenil is a competitive antagonist at the benzodiazepine binding site of the GABA_A receptor complex, reversing sedative, hypnotic, and amnestic effects of benzodiazepine and “Z?drug” agonists
Research Applications & Pharmacology
Sedation reversal models: Ideal for studies on benzodiazepine overdose and anesthesia recovery .
Receptor binding assays: Used to probe benzodiazepine site interactions via radiolabeled or functional displacement assays .
Pharmacokinetics & metabolism: Rapid onset (1–2?min), distribution half-life ~4–11?min, terminal 40–80?min; mainly hepatic metabolism with urinary excretion (~90?95%)
Withdrawal & tolerance studies: Used to precipitate acute withdrawal in long-term benzodiazepine models
Safety Profile & Handling
Preclinical side effects: In animal models, abrupt reversal can trigger convulsions, anxiety, and withdrawal seizures
Handling: Use PPE; reconstitute under sterile conditions; visually inspect before use.
Storage & disposal: Follow institutional biosafety and chemical waste protocols.
Core Keywords
flumazenil injection, benzodiazepine receptor antagonist, CAS?78755?81?4, sedation reversal research, GABA_A antagonist, overdose model reagent, Henan Runhong flumazenil
Research?Use Disclaimer
This product is intended exclusively for laboratory research purposes. It is not approved for clinical, therapeutic, diagnostic, or veterinary applications. Misuse may pose serious health risks. Users must comply with institutional safety guidelines.


Reviews
There are no reviews yet.