Description

Product Description

Fosfomycin Sodium (CAS 26016-99-9) is a broad-spectrum phosphonic acid antibiotic widely employed in preclinical microbiology and pharmacology research. As a small-molecule antibacterial agent, it irreversibly inhibits the enzyme MurA (UDP-N-acetylglucosamine enolpyruvyl transferase), blocking the first committed step of bacterial peptidoglycan biosynthesis. This unique mechanism makes it a valuable tool for mechanistic studies of bacterial cell wall formation, antibiotic synergy, and resistance pathways.

The Fosfomycin Sodium lyophilized powder form allows for precise preparation of solutions at defined concentrations, enhancing reproducibility in in vitro assays, time-kill studies, and in vivo preclinical models. Researchers commonly use Fosfomycin Sodium to study the effects of cell wall inhibition, bacterial growth suppression, and combination therapy with beta-lactams, aminoglycosides, or other antibiotics.

Mechanistically, Fosfomycin enters bacterial cells via glycerophosphate and hexose-6-phosphate transporters. Once inside, it covalently binds to MurA, preventing the conversion of UDP-N-acetylglucosamine to UDP-N-acetylmuramic acid. This leads to cell wall synthesis arrest, bacterial growth inhibition, and ultimately bactericidal activity. The compound is effective against both Gram-positive and Gram-negative bacteria, making it versatile for broad preclinical studies.

Fosfomycin Sodium is also used to evaluate bacterial resistance mechanisms, such as transporter mutations and fosfomycin-modifying enzymes. Its high-purity lyophilized form ensures stability, accuracy in experimental dosing, and compatibility with combination studies, pharmacokinetic profiling, and microbiological assays.

Product Specifications

Mechanism of Action

Cell Wall Synthesis Inhibition

Fosfomycin Sodium targets the MurA enzyme, blocking the formation of UDP-N-acetylmuramic acid, an essential precursor for bacterial peptidoglycan. This inhibition prevents cell wall synthesis and leads to bacterial cell lysis.

Transport and Uptake

• Enters bacteria via glycerophosphate and hexose-6-phosphate transporters

• High uptake efficiency contributes to broad-spectrum activity

Bactericidal Activity

• Arrests bacterial growth by inhibiting cell wall biosynthesis

• Rapidly induces cell death in susceptible Gram-positive and Gram-negative species

• Mechanistic studies include time-kill curves and bacteriolytic assessments

Resistance Mechanism Modeling

• Investigates transporter mutations affecting Fosfomycin uptake

• Evaluates bacterial FosA/FosB enzyme-mediated modifications

• Enables combination therapy research to overcome resistance

  

Applications

• Preclinical antibacterial studies

• Mechanistic investigation of peptidoglycan synthesis inhibition

• Resistance mechanism modeling

• Combination therapy and synergy studies

• In vitro and in vivo microbiology assays

• Pharmacokinetic and pharmacodynamic research

• High-throughput screening for antibacterial compounds

• Bacterial cytotoxicity and growth inhibition research

Side Effects (Preclinical Observations)

Cellular Effects:

• Inhibition of bacterial cell wall synthesis

• Growth arrest and cell lysis

Laboratory Handling:

• Use PPE when handling lyophilized powder

• Avoid inhalation, ingestion, or skin contact

• Handle in fume hood, dispose of as hazardous waste

Keywords

Fosfomycin Sodium, CAS 26016-99-9, lyophilized powder, MurA inhibitor, bacterial cell wall synthesis inhibitor, antibacterial research, cytotoxicity studies, combination therapy research, preclinical microbiology reagent, high-purity research chemical, laboratory antibiotic, OEM & bulk supply.

Shipping Guarantee

Fosfomycin Sodium lyophilized powder is packaged to protect from moisture and shipped via international express couriers with temperature monitoring where necessary. Packages are insured and tracked to ensure compound integrity.

Trade Assurance

• ≥99% purity verified by HPLC, MS, NMR

• Batch consistency confirmed

• Certificate of Analysis (CoA) included

• OEM & bulk packaging available

• Replacement or refund guaranteed for specification deviation

Payment Support

• PayPal

• Credit Cards (Visa, MasterCard, AmEx)

• Bank Transfer (T/T)

• USDT / BTC / ETH

• Corporate invoicing for bulk orders

Disclaimer

Fosfomycin Sodium is supplied for laboratory research only. Not for human or veterinary use. Researchers must adhere to institutional safety guidelines. Supplier assumes no liability for misuse.

References 

• PubChem – Fosfomycin Sodium

• DrugBank – Fosfomycin

• ChEMBL – Fosfomycin

• IUPHAR Guide – Antibiotics

• PubMed: Fosfomycin Mechanisms