Gersizangitide – High Purity 98.05% – GMP Manufacturer

描述

Gersizangitide (CAS No.?2417491-82-6), also known as AXT-107, is a synthetic 20-amino acid peptide derived from collagen IV. It functions as an angiogenesis inhibitor by binding to integrins ???? and ?v??, suppressing vascular endothelial growth factor (VEGF) signaling, and promoting angiopoietin-2-induced Tie2 activation. This dual mechanism effectively inhibits neovascularization, vascular leakage, and inflammation, offering a promising approach for treating neovascular retinal diseases.

This compound has potential applications in the research of conditions such as diabetic macular edema (DME), wet age-related macular degeneration (wet AMD), and retinal vein occlusion (RVO). Gersizangitide is manufactured under GMP standards with a purity of 98.05%, ensuring consistency and reliability for experimental use.

Product Specifications

Mechanism of Action & Research Applications

Mechanism of Action:
Gersizangitide is a synthetic peptide that selectively binds to integrins ???? and ?v??, which are upregulated on endothelial cells in neovascular tissues. By binding to these integrins, Gersizangitide inhibits VEGF receptor signaling and promotes Tie2 activation via angiopoietin-2, leading to suppression of neovascularization, vascular leakage, and inflammation.

Research Applications:

• Diabetic Macular Edema (DME): Investigating treatments that reduce retinal vascular leakage and edema.

• Wet Age-Related Macular Degeneration (wet AMD): Exploring therapies that inhibit abnormal blood vessel growth in the retina.

• Retinal Vein Occlusion (RVO): Studying compounds that address vascular leakage and neovascularization in retinal veins.

  

Side Effects (Research Context Only)

Gersizangitide is intended for laboratory research use only. In preclinical studies, it has been shown to reduce neovascularization and vascular leakage without significant adverse effects. However, as with all experimental compounds, appropriate safety protocols should be followed during handling and administration.

Disclaimer

Gersizangitide is strictly for laboratory research use only. It is not approved for clinical, diagnostic, or therapeutic purposes. Users should adhere to institutional safety guidelines and regulatory requirements when handling this compound.