Description

Glipizide Tablets 2.5mg, branded by Disha Pharmaceuticals, are oral hypoglycemic agents from the sulfonylurea class, designed for laboratory and experimental purposes only. Commonly used in academic and pre-clinical settings, these tablets are ideal for investigating pancreatic beta-cell stimulation, insulin release mechanisms, and type 2 diabetes research.

This product is not intended for human therapeutic use. It is offered for use in in vitro studies or animal models under controlled laboratory conditions.

Product Parameters

Mechanism & Research Applications

Glipizide acts by stimulating pancreatic beta cells to release insulin, effectively lowering blood glucose levels. As a second-generation sulfonylurea, it has a faster onset and shorter duration of action compared to earlier analogs.

In research, it is commonly applied to:

• Study insulinotropic mechanisms

• Investigate sulfonylurea receptor (SUR1) binding in pancreatic cells

• Develop in vivo models of type 2 diabetes mellitus (T2DM)

• Analyze glucose-lowering pharmacodynamics

Its well-documented action on K⁺-ATP channels in beta cells makes it a benchmark reference compound in diabetes pharmacology research.

Observed Effects in Research

• Increased endogenous insulin secretion

• Decreased fasting and postprandial glucose

• Stimulated islet beta-cell activity

• Improved glucose tolerance in animal models

• Enhanced glucose-stimulated insulin secretion (GSIS)

Safety & Handling

• Research Use Only – Not for diagnostic or therapeutic use

• Storage – Store in a dry place, protected from light

• Handling – Wear protective gear during handling

• Shelf Life – Refer to box label for expiry

• Disposal – Follow institutional lab waste protocols

Research Use Disclaimer

This product is intended for experimental laboratory research only. It is not for human or veterinary use. Misuse may violate applicable regulations. Not for therapeutic, diagnostic, or dietary use.